[quote]BoSlice wrote:
Ok so, I think, that the liver receives blood from the small intestine and also from circulation.
So with oral ingestion the 17aa hormone passes through the liver from blood from the small intestine.
After injection, the hormone enters the bloodstream via capillaries. This blood then eventually passes through the liver, hormone, alkylation and all?
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Dude, there’s a fundamental difference between liver absorption from the hepatic portal vein (which is precisely what we’re referring to as first pass metabolism), and that which occurs after a substance has fully entered the bloodstream (systemic).