Good to see someone bring this up, i’ve known this for about 10 years, just never thought about bringing it up.
Would this enhance the effect of smoking or eating Cannabis? I’m going to try some time this week.
Has anyone tried this?
Oddly enough I know that it enhances LSD…
Learned this when I was a wee lad.
[quote]bushidobadboy wrote:
Shire wrote:
Would this enhance the effect of smoking or eating Cannabis? I’m going to try some time this week.
Has anyone tried this?
Interesting question. I would guess that it might have some effect on eating, but possibly not much as cannabinoids are naturally occuring in the brain anyway and might therefore not be seen by the liver as a toxin/foreign substance.
Smoking would, I think, be unaffected, since it involves absorbtion through the lungs.
Bushy[/quote]
Maybe i’ll smoke weed using a grapefruit bong.
[quote]Nich wrote:
football061 wrote:
This may be a stupid question but what about typical vitamins and supplements? What if you were to take say tribulus, BCAA’s, creatine and your multi V etc. with grapefruit juice? Does it enhance the effects of these? I’m about to start taking Advil with grapefruit juice when I have headaches and typical aches and pains. If it increases the effectivenss of the Ibruprofen it should allow for better pain relief. Right?
not a stupid question at all.
I have no idea about the supplments or the vits,mainly becuase you cant “feel” these working
I mean when you take pain killers or advil and you feel the difference you know it works.
[/quote]
As far as I am aware, grapefruit juice only affects compounds that are metabolized through the P450 system (specifically the isoenzyme CYP3A4) , so the only enhancement effect you will see is taking grapefruit juice before ingesting a mineral/vitamin/drug metabolized by P450. To my knowledge, most vitamins are not of that subset. I believe there may be a few though (vitamin D comes to mind), but I’m too lazy to look it up.
I do believe finasteride and avodart are both metabolized by P450 and specifically CYP3A4, and perhaps P450’s other isoenzymes, so you might have luck there. CYP enzymes are also involved in steroid metabolism, and at least one of them has 17alpha hydroxylase activity, and another has aromatase activity.
EDIT: Ok, check out this link over the P450 family of enzymes… pretty good overview actually.
EDIT #2: here’s a nice overview. http://drnelson.utmem.edu/P450lect.html
my wife and i have used grapefruit juice successfully to potentate oxy and hydrocodone before… it does work.
Also, Tagamet(US) is very effective in potentating oral methadone… this i believe is due to the effects it has on gastric acids thus increasing absorbtion and decreasing destruction of certain chemicals…
Might be of interest to you lot.
I cannot see why the two would not work for oral AAS.
Anybody know if these same effects can be obtained through using grapefruit seed extract? Or is it just the juice?
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