What the title says. New here looking for advice. My current doctor because of hcg not available, wants to put me on gonadorelin with my original protocol of 200mg of testosterone. does anyone have any thoughts on this or any experience with gonadorelin?
No direct experience, indirectly only with anovulatory women. Is it expensive?
By the way, hCG is available, it is just not allowed to be made by compounding pharmacies.
After doing some digging since a clinic i know is no longer using hCG, a called a few pharmacies and found out they are going to be offering Gonadorelin and NOT Kisspeptin. Kisspeptin is a peptide and it is NOT approved to be compounded and states like California will not approve it, while Gonadorelin is allowed to be compounded. Does anyone have any input on this?
Gonadorelin is a branded synthetic version of GnRH. It’s been commercially available since the early 80’s under various brand names. Honestly, I don’t see how it can be logistically incorporated into a TRT protocol. GnRH requires pulsatile infusion otherwise there is rapid down-regulation of GnRH receptors on the pituitary. I did my master’s thesis on this topic many, many years ago.
I’ve read of some fertility protocols where men or women (depending on who is infertile and why) use portable infusion pumps to pulse GnRH into the subcutaneous tissue, but this requires a lot of motivation and is not intended as a long-term treatment.
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Exactly what you said. GnRH needs to be given multiple times per day. If an agonist is given chronically, you’ll go from the “flare up phenomenon” to 0 LH and FSH as seen in cancer patients receiving GnRH agonists. (Interestingly Agonists (Superagonists) get used instead of Antagonists because the shutdown from an agonist is reliable). If it is given frequently that’s a procedure that’s done with boys with delayed puberty or absence of a working hypothalamus, so it can work but not in conjunction with T. The doctor should seriously be questioned about his knowledge or I’m missing something.
I know this for a long time now, what really shook me was the research you provided on nasal testosterone application and the subsequent absence of suppression.
Back to the topic: As you said -
The research you posted indicates indirectly that if you’d take a SERM to block E2 receptors at the pituitary level, you could pulse GnRH to uphold natural levels of LH and FSH and subsequently fertility if you’re on exogenous T. I don’t know why but my gut tells me that won’t work. I’ll try to look at some papers and post my opinion when I find the time in the next days.
Yes I am, currently finishing the pharmacy days up. Hope you are doing good too.
I read it and he really does a good job of experimenting scientifically. He’s right about the pump in the future. One of my problems with TRT (though I’m probably gonna be on some day) Always was that I don’t think that GnRH, LH, FSH are useless besides T and sperm production. Very interesting that the addition of a SERM really works that good. Shows that the research is right in this. No T receptors in the pituitary.
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