Sorry if this has been addressed. Since HCG is now unavailable at compounding pharmacies, has anyone had experience with GnRH use? If so what is your dosing protocol?
There’s a guy on excelmale keeping a log of using GnRH, I think he found some success his only complaint was that you needed to dose several times a day.
HCG is still available from regular pharmacies, and I believe a bill is being written to change the language on the law the FDA is using to stop compounded biologics
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Yes that’s important otherwise the receptors desensitize and you’ll get complete suppression like a prostate cancer patient. That’s why they apply leuproreline as a depot, it completely shuts down the pituitary.
I’ve been experimenting with kisspeptin-10 at 100 mcg every day.
Have you measured your LH/FSH levels since trying? Also thanks for everyones response.
I have not. I actually wasn’t entirely honest with my protocol in order to avoid looking like a maniac. It appears that if you have access to sit around, hooked up to an IV Saline solution that administers 1.0 mcg/kg of body weight per hour, that is the most effective way to boost LH/FSH via Kisspeptin increasing GNRH. This method obviously isn’t realistic on a day to day basis.
Researchers also studied individual doses. Ironically 1.0 mcg/kg of body weight was more effective than 3.0 mcg/kg suggesting that more is not better with this peptide.
After a bolus injection of 1.0 mcg/kg of bodyweight, LH/FSH peaked in 30 minutes and then dropped down after 90 minutes, which suggests it pulses our LH/FSH and doesn’t provide a sustained release when injected acutely in one dose.
Yesterday, because I’m still able to work from home remotely, I’ve begun experimenting with 100 mcg (I’m 200 lbs) 3 times per day. Once upon waking, once around noon and once before bed - a total of 300 mcg/day.
Prior to this, I was injecting 100 mcg/day for the last week.
I’m someone who feels horrible on hCG and I’ve been on TRT for about 5-6 years; so I’ve never stopped searching for an alternative.
Even more impressive about Kisspeptin-10 is there appears to be no desensitization after continuous exposure. There’s other benefits outside of increasing LH/FSH/Testosterone including energy balance, cancer protection, memory enhancement and also kidney/heart health.
I can tell you that in almost every way, I “feel” better. Libido, leanness, muscle mass, mood, attention, testicular size have all improved. Without any dietary changes, I’ve actually gone from 198 to 202 in one week and look leaner.
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Thanks, this is interesting. I don’t do well on HCG, it has a significant negative impact on my mood, which I have assumed is due to the increased aromatisation. I wonder if the same will happen here as it certainly stimulates T production. I’d love to have the benefits of HCG without the sides.
I don’t believe it’s due to aromatization resulting in increased estrogen because I’ve had it tested plenty of times while taking hCG and my estrogen didn’t appear significantly higher than when I wasnt taking hCG.
I’ve read that in some, it increases another hormone (I cannot remember the name & am too busy to search for it right now) that essentially causes hypertension and water retention.
I too notice irritability, water retention, headaches, higher blood pressure and difficulty sleeping when taking hCG.
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Aldosterone? I’ve seen that as the cause for water retention or bloating before
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Yes thank you. That’s the one.