Again, most likely sativa. It is a lot more energizing and focusing. While it can relax you its mostly a brain high. Using sativa you WANT to get shit done. You feel driven and motivated.
Tamoxifen has potent antiestrogenic effects and some of its metabolites are potent aromatase inhibitors.
Can you post links or something to elaborate on this statement? I’ve done quite a bit of reading on the topic and I dont believe I’ve read anything like this. I know tamoxifen has potent metabolites but they have a higher affinity for binding to the ER site. I wouldn’t classify that as an ai. It’s a serm acting like a serm.
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Norendoxifen (N,N-didesmethyl-4-hydroxytamoxifen), another active metabolite of tamoxifen, has been found to act as a potent competitive aromatase inhibitor (IC50 = 90 nM), and may also be involved in its antiestrogenic activity.[62]
And 4-OHT competes with estrogen at the receptor.
My wife can’t function on it either. She tried it one time for anxiety and told me she never wanted to even see that shit again in her life. She hated it.
I have probably tried it 5-6 times in my entire life. Everybody I knew growing up smoked it. I have always been against drugs because of all the abuse of drugs I saw as a kid. It took me till I was over 30 years old to even learn to enjoy a recreational drink. I just hated it all. There never was a “good” time that I can recall. Maybe the people smoking it where having a blast, but me being sober, they all looked like bumbling idiots and most of the time they started combining it with alcohol. I don’t think I’ve ever seen one of those sessions that didn’t end up somebody getting pissed and starting a fight. Just not for me.
Probably the wrong kind for her and it sounds like probably too much. The right amount should give the euphoria of like one to two drinks over 90 mins (depending on weight). You can feel it but its just uplifting a bit. If its legal in your state or you go somewhere where it is legal a shop should be able to guide her to what would work best for her situation.
So one puff from a pipe is too much? No offense man, but if the threshold of tolerance is that tight, she’s better off not fucking with it in the first place.
I tried that shit when I was a kid and hated it. Very short lived. Maybe it was bad stuff.
She probably won’t try it again. The chance is gone haha… I don’t blame her.
Maybe. Depends on what it was. This is why legalization and standardization is important. That being said I understand it isn’t for everyone just like booze isn’t, penicillin, codeine, etc. It just effects people differently.
My brother is an avid smoker and the stuff he gets kicks the shit out of me with one puff…like for hours. The stuff I get I can have a few pulls and feel great with no anxiety, paranoia, etc.
For me, yes, one puff is too much. However, a very low dose of THC/CBD oil mellows me out without getting me high at all.
When I go to Oregon (legal), I always pick up a vial or two. And I get the lowest concentration available and cut the dose in half (three drops instead of six).
I found straight CBD puts me to sleep, but a THC/CBD combo relaxes me.
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@physioLojik I’ve seen you recommending trytophan above but when searching for some I’ve see warnings about its safety and possibly causing a verve condition. Is this scaremongering or are there any concerns with its use? Thanks
Tryptophan is in most foods we eat. The issue our bodies have is absorption, as tryptophan competes with other essential aminos for absorption… and usually loses.
Trypto is fairly safe. I do about 500mg a night and it helps with sleep.
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That’s cool mate. I looked on webmd to see what it’s invilved with etc and it talks about a really nasty condition… but it does say this could have been contamination at an early producers factory…
Weed didn’t do that to you. Not exercising your brain during that period of time did.
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@anon10035199 I was playing high end strategy games for hours on the PC everyday, conquering nations, taking over the world on maximum difficulty settings. My guitar skills went to Jimi Hendrix level lol I was creating these masterpiece solos, the weed puts the mind right into the zone. It improves creativity and awareness when doin certain things like playing guitar for example. I could never play sober like I do stoned.
The downside I found after years of abuse was my social skills went to fuck. I couldn’t hold a conversation and it was hectic trying to remember things like of quiz shows. It was also starting to make me lazy and depressed.The stuff I grew wasn’t your normal run of the mill stuff u buy on the street, this was heavy heavy shit like straight out of Amsterdam. I spent a fortune on the equipment and the feeds etc. My mates couldn’t handle my stuff.
So it improves the brain in some ways and messes it up in other ways. Now I only puff it sensibly, mostly at night or after a high volume workout, that’s the few hours Jimi Hendrix comes back to life lol. I know how to say no now and this works best for me, smoking that shit morning to night for years would most certainly fuck ones mind up. Everything in moderation they say.
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Not knocking video games at all. (was it hearts of iron? by chance?) But I was talking more of the sense of being social and reading books. Not to say those things don’t stimulate the mind to an extent, especially playing guitar.
I do agree that constant use with little mental stimulation will eventually lead to the scenario you are describing.
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Ha, no they where the days of command and conquer and total war games. I found Civ to be easier but very enjoyable even being turn based. I micro managed everything in detail, but I loved the real time fast paced games. Do you remember these days ?
That was my problem, it made me anti social after a period. I found it difficult to be in places with more people. Standing in a lift for instance would have been a nightmare, either I would start laughing then feeling paranoid about it, or I would feel panic setting in when in places like shopping centres. This isn’t me when sober, I’m normally confident and chatty. It is certainly the weed causes this, well to me anyway. I know some people puff and are social, but not me. It made me a paranoid recluse… upside I became quite good on the guitar lol
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Oh yea, I loved CNC. I thought maybe you had played hearts of iron because it is VERY intensive. Not just point and click.
There is no arguing with its benefits when it comes to sleep.
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