Fertility Treatment with HMG & HCG - Do I Need to Stop TRT?

@vonko1988
It sounds plausible but I’ve had enough reassurance from doctors and folks with real world experience that I’m ok with my choice. The human body is pretty amazing in what it can do. I’ve also learned in life that more is lost in indecision than wrong decisions and I’ve made mine.

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@dextermorgan
I guess you are totally right as usual.
I have another question for you that is off topic:
How do you manage your HCT and hemoglobin with the high test levels you maintain?
If the moderator deems to move it to another topic…

@vonko1988
I was anemic pre-trt and my HCT was 38. Post-trt my HCT is 47 after supplementing Iron. That said I know quite a few people who’s HCT is <52 on the same dose so I guess it really boils down to genetics. I would think most people on 150-200mg don’t have crazy HCT levels.

I see, thanks.
My pre TRT HCT is like 44-46, hope it doesnt go too high and I know this happens until month 6.
Many people say HCT is the most potent limiting factor in TRT

This is what the science says. Everyhting else is personal experience and strongly biased towards their own stories.

Its just increadible how much false information on such an important and personal topic is spread with confidence.

‘Testosterone as a contraceptive can suppress spermatogenesis and lead to azoospermia in 65% of normospermic men within 4 months of use [14]. Cessation of exogenous testosterone will lead to the reversal of hormonally-induced azoospermia in 64% to 84% of men with a median time of about 110 days [13,14,15]. All men in these studies recovered to baseline levels after cessation of therapy; however, it took up to 2 years for some men to recover. These studies were performed in a controlled setting for a clinical trial, with a limited duration of testosterone use. In actual practice, recovery may not be as pronounced. Kohn et al [16] studied spermatogenesis recovery with human chorionic gonadotropin (hCG) and selective estrogen receptor modulators (SERM) in men with infertility associated with testosterone use. Thirty percent of the 66 men were not able to achieve a total motile sperm count of more than 5 million after 12 months in the study. They found that the failure of recovery is associated with older patients and longer TRT duration.’

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Some interesting reading for others planning to go down the hcg & hmg route:

one man out of the eight (13%) failed to produce any spermatozoa despite treatment with HCG and r-hFSH. This proportion of failed treatment is comparable with that reported in previous larger studies. Similarly, the median time to appearance of spermatozoa (6 months) is very similar to previous studies (5–6 months)

https://academic.oup.com/humrep/article/14/6/1540/2919268

Id like to see such a study performed only on men who lost fertility due to TRT. If I understand correctly here the causes are unknown.

“All men had hypogonadotrophic hypogonadism due to pituitary or hypothalamic disease confirmed by imaging of the pituitary fossa (by computed tomography or skull X-ray), hormone assays (including pituitary stimulation tests) and karyotype. Two men had anosmia.”

Not a perfect comparison but the long term shutdown of lh/fsh production experienced by the subjects in the study could be similar in some cases to guys under going long term trt without hcg

Could but this is an assumption. This guys could never have been fertile in their lives and their testicles may have never developed. Mine is an assumption as well, just like yours.
We must say what dr Neil Rouzier ofter says regarding studies: Association does not mean causation. To prove causation you must intervene - take this men, make them infertile with testosterone and then try to reverse that

Did the OP conceive? @luke81

SB

Yes.
Stayed on trt & continued the treatment outlined in the original post.
Sperm count reached 10million after 70 days treatment. Increased to 75million after 120days. We conceived around the 90day mark.
We now have a 1 year old child

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Amazing news!

Congratulations. Was it a girl?

SB

@luke81 -thank you for posting your success story as it just gave me a little hope. I was on testosterone from age 17-40 without any real break. My semen analysis showed zero sperm so I came off 2 years ago and as of 3 weeks ago my testosterone is still only a 28. My last semen analysis (1 year ago) showed great progress but my T levels are to low to perform and have been concerned about getting back on T and including HCG, Clomid, and HMG as I felt it would be like having one foot in and one foot out of trying to have a kid.