Fat Adapted?

[quote]PB Andy wrote:
I thought there was a metabolic advantage to low carbs? Here’s an excerpt for Jonny Bowden’s (PhD, CNS) ‘Living Low Carb’ book (before this quote, he explains the results of studies that go into the metabolic advantage…):

“Moral of the story: calories do count–but they’re not the whole story. Low-carb diets may have a metabolic advantage, but it’s not unlimited. In fact, it’s probably pretty small (200-400 calories, suggests Mike Eades). You can’t eat 12,000 calories a day if fat and protein and think you’re going to lose weight just because you’re on a low-carb diet. You still need to pay attention to calories. But you do have a bit–and I do mean a bit–of wiggle room on low-carb.”[/quote]

No metabolic advantage has been demonstrated in studies going back 70+ years where subjects are confined and have their meals monitored and allotted for 24/7.

Well, I can’t say “none”, really, since I haven’t read every single study in existence. But the VAST majority saw no difference in weight loss when calories and protein are controlled for.

Most studies that DO see a difference are the “free living” sort (as opposed to metabolic ward ones), in which all sorts of confounding factors can come into play. Even then, things often tend to even out in the long run.

[quote]anonym wrote:

[quote]PB Andy wrote:
I thought there was a metabolic advantage to low carbs? Here’s an excerpt for Jonny Bowden’s (PhD, CNS) ‘Living Low Carb’ book (before this quote, he explains the results of studies that go into the metabolic advantage…):

“Moral of the story: calories do count–but they’re not the whole story. Low-carb diets may have a metabolic advantage, but it’s not unlimited. In fact, it’s probably pretty small (200-400 calories, suggests Mike Eades). You can’t eat 12,000 calories a day if fat and protein and think you’re going to lose weight just because you’re on a low-carb diet. You still need to pay attention to calories. But you do have a bit–and I do mean a bit–of wiggle room on low-carb.”[/quote]

No metabolic advantage has been demonstrated in studies going back 70+ years where subjects are confined and have their meals monitored and allotted for 24/7.

Well, I can’t say “none”, really, since I haven’t read every single study in existence. But the VAST majority saw no difference in weight loss when calories and protein are controlled for.

Most studies that DO see a difference are the “free living” sort (as opposed to metabolic ward ones), in which all sorts of confounding factors can come into play. Even then, things often tend to even out in the long run.[/quote]
Hmm… well I just don’t think you are correct on there being NO metabolic advantage. Bowden says the opposite (as do others in his book which I will include in excerpts below); he says there is a metabolic advantage but it’s just not very big.

EXCERPT #1

“There are numerous examples of low-carbohydrate diets being more effective than low-fat diets with the same number of calories”, says Dr. Richard D. Feinman, PhD, professor or biochemisty at the SUNY Downstate Medical Center. “Everyone with good sense believes there’s a metabolic advantage,” adds my friend Mikes Eades, MD.

EXCERPT #2

One of the best studies I know of to demonstrate this is an ingenious one done by Penelope Greene at the Harvard School of Public Health in 2003. Here’s what she did.

Dr. Greene studied three groups of dieters. The first group went on a 1500-calorie-per-day low-fat diet (1,800 for men). The second group went on an 1,800=calorie low-carb diet (2,100 calories for men). If all calories are created equal, the second group–which consumed more calories–should have weighted a bit more at the end of the study than the first group.

They didn’t. Though both groups lost weight, the low-carb (higher-calorie) group actually lost a little more, despite the fact that over the 12-week study they ate an average of 25,000 calories more than the low-fat group.

But, you say, what about the third group?

Glad you asked, because here is where it gets interesting. Sharp-eyed readers might have noticed that the two groups discussed above actually differed in two variables, not just one. They ate different amounts of calories (1,500-1,800 for group one, 1,800-2,100 for group two), but they also ate different food–low-fat for group one, low-carb for group two.

What would happen, Dr. Greene wondered, if there was a third group that ate the same type of food as group two (low-carb) but the same number of calories as group one (1,500-1,800)?

And that, indeed, was the third group in the study. Low-carlorie and low-carb.

That group lost the most weight of all.

EXCERPT #3

I mentioned earier that a number of studies showed that low-carb diets have an advantage right out of the starting gate, when compared with conventional diets for weight loss. Time and again, we see low-carbers beating the competition at the six-month mark, only to see no substantial difference between the two groups by the end of a year or two. Why does this happen?

I don’t know, but I have a theory.

I think what happens is this: People do really well on their “protein and fat” carb-limited program, and stick with it pretty religiously for a few months. Then they get complacent. They think, hey, things are going pretty good, maybe I can add some carbs back. Before you know it, they’re eating that same "meat and eggs’ breakfast, but now they’ve got a few slices of toast with it, and maybe a glass of orange juice. They’re back to a high-calorie “mixed” diet, even though they’re still technically being treated by the researchers as members of the “low-carb” group. It’s no surprise that these folks gain their lost weight back. It’s actually a tribute to how well low-carb does that even staying on it even a little produces better results than not staying on it at all.

another excerpt on the whole “Law of Thermodynamics” argument that many uses:

EXCERPT #4

First, let’s demolish the idea that being able to eat somewhat more calories on a carb-restricted diet and still lost weight violates the sacred “First Law of Thermodynamics.” Which it seems to do.

The operative word is “seem”. But if you ask people who actually understand the law of thermodynamics, you come up with a quite different take on it. According to a paper published by Richard Feinman, PhD, founder of the Nutrition and Metabolism Society, it appears that naysayers may not understand thermodynamics nearly as well as they think they do.

The naysayers don’t account for another part of the laws of thermodynamics which basically talks about waste and inefficiency. Turns out, lots of calories are actually wasted during the process of metabolism, and some calories tend to be wasted more than others. That’s because some forms of “energy” (calories) are more efficient; glucose molecules, for example, tend to be used for energy right away. They’re like coins you have in your pocket–easier and faster to use than if you have to go to the ATM to get your cash. If you’re using mainly protein and fat for fuel, it’s like having to go ATM. You still use cash, but you’ve wasted a lot of time (and energy) converting that ATM swipe into something the clerk at the cash-only supermarket will accept. Those extra calories that low-carbers may consume don’t actually “disappear” at all-- they’re just “burned” in the process of being converted to usable fuel for the body.

[quote]PB Andy wrote:
EXCERPT #3
I don’t know, but I have a theory.

I think what happens is this: People do really well on their “protein and fat” carb-limited program, and stick with it pretty religiously for a few months. Then they get complacent. They think, hey, things are going pretty good, maybe I can add some carbs back. Before you know it, they’re eating that same "meat and eggs’ breakfast, but now they’ve got a few slices of toast with it, and maybe a glass of orange juice. They’re back to a high-calorie “mixed” diet, even though they’re still technically being treated by the researchers as members of the “low-carb” group. It’s no surprise that these folks gain their lost weight back. It’s actually a tribute to how well low-carb does that even staying on it even a little produces better results than not staying on it at all.[/quote]

Certainly a reasonable assumption.

Even amongst intellignet (ie. dialed-in) physique conscious individuals who do exercise regularly, there’s the common trend of low-carb “working” well initially, which often leads into a “carbophobia” period, which then itself disappears as they keep progressing/getting leaner. I’m obviously referring to those who aren’t naturally lean, ie. the majority.

The key, once again, is finding out what works for you.

Or as anonym phrased it few pages back:

[quote]anonym wrote:
For fat loss, any caloric deficit will get the ball rolling. Macro-wise, it’s really a matter of individual preference; one can get “lean” on bth LF and LC diets, so whatever keeps you feeling good enough to exercise and motivated enough to persevere will get the job done. I know that’s probably a disappointing answer, but it really isn’t rocket surgery and I don’t want to make it sound like it is just so I can feel smart about my opinion…[/quote]

Not in metabolic ward studies, there aren’t.

A free living study, I assume? If I have time I’ll take a look… but, again, when people are actually confined and monitored these sorts of things do not occur once water weight is accounted for.

Not hugely interested in playing a guessing game with someone who isn’t actually here, but I think that’s kind of a silly argument for a couple reasons I’ll address tomorrow.

Was the Feinman paper titled “A calorie is a calorie” violates the second law of thermodynamics?

If so, we’ve discussed it already in a previous thread and dismissed it because Feinman can’t do basic math and showcased a laughable misunderstanding of the argument at hand.

[quote]PB Andy wrote:
Hmm… well I just don’t think you are correct on there being NO metabolic advantage.[/quote]

Again, you and others can think whatever you like. But, until you control dietary and behavioral variables as strictly as all those metabolic ward studies going back decades and decades (and finding no difference between LC and LF diets), it doesn’t mean a heck of a lot.

LC CAN work better, but not for the reasons they are saying it does. The evidence is simply not there when put under the most rigorous standards reasonably available.

[quote]deepsquats220 wrote:
I think there is a mix-up in everyone’s terminology here. Fat is generally treated as a more efficient storage than something like glycogen. This is because glycogen is polar, and it binds around twice its weight in water in the body. However, fats are non-polar and therefore do not bind water. Coupled with the fact that fats yield 9 calories per unit mass where carbs yield 4, someone could make the argument that fats are more efficient method of storage.[/quote]

OK, for those who don’t speak geek:

Stored fat is almost entirely devoid of water and yields ~9kcal per gram.

Glycogen, on the other hand, binds to water in a 1:2 ratio (1 gram glycogen to 2 grams water) and yields ~4kcal per gram. So, each gram of glycogen you store ultimately weighs 3 grams.

From this, we see that one gram of fat yields 9kcal/1g = 9 calories per gram, whereas glycogen yields 4kcal/3g = 1.3 kcal/gram.

From there, we go 9/1.3 = 6.9 times as much energy from fat on a “per gram” basis. Obviously, fat contains SOME water (10 - 12%, or so), so we round it down ~6x because it’s late and we (I) am too lazy to be pedantic about it.

So, yes, fat is absolutely a more efficient method of storage.

The Feinman (and his colleague Eugene J. Fine, PhD) article was called “Thermodynamic Edge for Low Carbohydrate Diets”.

Interesting discussion, nonetheless.

[quote]LIFTICVSMAXIMVS wrote:

[quote]Professor X wrote:

[quote]LIFTICVSMAXIMVS wrote:

And it does, it can use ketone bodies that are produced from fat. [/quote]

That is not the most efficient way to fuel your brain. Yes, your body can do that because once again, we are designed to not die simply because one aspect of our diet is missing. That doesn’t mean you should force it in all cases and once again, this comes down to results seen and PREFERENCE. Trying to make it seem like “glucose equals bad” is simply oversimplified and incorrect.

Your body is a beautiful complex machine. What bothers me is people who ignore the complexity to come up with simple “in the box” static answers to every diet question.
[/quote]

Glucose is not bad; however ingesting it in large doses might be.

Like Deepsquats said above, I think efficiency has more to do with it.

Fatty acid oxidation is much more efficient than glycolysis. For every molecule of fatty acid that is completely oxidized we can get:

[(n/2)*12 + (n/2 - 1)*5] - 2 molecules ATP - where n is the number of carbon atoms in the fatty acid chain.

A 18 carbon fatty acid produces 146 molecules of ATP.

One molecule of glucose can only produce 36 net molecules of ATP. Both lipolysis and glycolysis require exactly 2 molecules of ATP energy in their pathway. Fat can be 400% more efficient than glucose if we consider the 18 carbon stearic acid - on average it is only 225% greater (which is why fats have 9 calories per gram versus 4 for glucose).

Ketone bodies are just a by product of unused acetyl-coA which we get for free from oxidation of fatty acids. Acetyl-CoA also produces ATP but when fatty acids are being broken down so quickly that their resulting A-CoA cannot be utilized they go to making beta-hydroxybutyrate.

Win-win.[/quote]

This is the only thing I don’t really understand from a biochemical standpoint. Fats are less oxidized so they will yield more ATP, so why aren’t fats the typical unit of exchange for daily functioning? My only guess would be a lack of cofactors required to oxidize them? Not sure…

[quote]LIFTICVSMAXIMVS wrote:

[quote]rds63799 wrote:
wow, sounds like total calories was your enemy then, not so much carbohydrate (although I’m sure your soft drink addiction didn’t help).[/quote]

Right, but my calories were only around 3000 per day and I was lifting 5 times per week.

I am currently upward in direction again at 225 having gone down to 210.[/quote]

congrats on your weight loss, but if you think you got up to 300lbs eating 3000 calories a day I think you are grossly underestimating how much you were eating

[quote]anonym wrote:

[quote]LIFTICVSMAXIMVS wrote:
This means I don’t need glycogen to run sprints or to perform a heavy squat routine.[/quote]

No, what this means is that your definition of intensity wrt sprinting and lifting is completely different than that of most serious lifters and athletes.
[/quote]

you are completely wrong.

[quote]anonym wrote:
So, yes, fat is absolutely a more efficient method of storage.[/quote]

I believe the energy from fat has been miscalculated because they average all the energy from every type of fat.

In humans where we make and store long chain fatty acids more abundantly than short chain fatty acids, it can yield up to 16 calories per gram.

The bottom line: what matters most is how much ATP each molecule of fuel substrate produces.

18 and 16 chain carbon molecule fatty acids are the most abundant and yield more than 9 calories per gram.

I can do the math if you like.

[quote]rds63799 wrote:

[quote]LIFTICVSMAXIMVS wrote:

[quote]rds63799 wrote:
wow, sounds like total calories was your enemy then, not so much carbohydrate (although I’m sure your soft drink addiction didn’t help).[/quote]

Right, but my calories were only around 3000 per day and I was lifting 5 times per week.

I am currently upward in direction again at 225 having gone down to 210.[/quote]

congrats on your weight loss, but if you think you got up to 300lbs eating 3000 calories a day I think you are grossly underestimating how much you were eating[/quote]

As a trained physicist I am very meticulous about note taking and measuring.

[quote]LIFTICVSMAXIMVS wrote:

[quote]rds63799 wrote:

[quote]LIFTICVSMAXIMVS wrote:

[quote]rds63799 wrote:
wow, sounds like total calories was your enemy then, not so much carbohydrate (although I’m sure your soft drink addiction didn’t help).[/quote]

Right, but my calories were only around 3000 per day and I was lifting 5 times per week.

I am currently upward in direction again at 225 having gone down to 210.[/quote]

congrats on your weight loss, but if you think you got up to 300lbs eating 3000 calories a day I think you are grossly underestimating how much you were eating[/quote]

As a trained physicist I am very meticulous about note taking and measuring.[/quote]

as a psychologist, I know that people are usually wrong about how good they are at stuff they think they’re good at :slight_smile:

[quote]LIFTICVSMAXIMVS wrote:
I can do the math if you like.[/quote]

I’d actually prefer you to show some evidence supporting your assertions from our earlier discussion. While it might be fun to correct an example illustrating the comparative efficiency of lipid storage versus glycogen, it’s both pedantic (which is interesting considering your use of outdated P/O ratios, which produce inflated ATP yields from NADH and FADH2) and prone to inaccuracies because ATP yield will depend on the shuttle system used to transport NADH+H into the mitochondria as well as fatty acid length and degree of saturation. Besides, the fatty acid composition of adipose tissue is dependent upon diet and sample site, so we will see individual variation there, as well.

tl;dr: who cares? Either way, fat is a more efficient means of energy storage, which explains why our bodies would rather pile that on than glycogen.

[edit] here’s what I mean:

http://www.ncbi.nlm.nih.gov/books/NBK22369/

Even authors of biochemistry textbooks think it’s unnecessarily tedious to attempt better precision with the comparison.

[quote]PB Andy wrote:
The Feinman (and his colleague Eugene J. Fine, PhD) article was called “Thermodynamic Edge for Low Carbohydrate Diets”.

Interesting discussion, nonetheless.[/quote]

I can’t for the life of me find this paper. It’s not on the website it claims to have been published on and Google isn’t being much help.

Can anyone else find it?

[quote]anonym wrote:

[quote]PB Andy wrote:
The Feinman (and his colleague Eugene J. Fine, PhD) article was called “Thermodynamic Edge for Low Carbohydrate Diets”.

Interesting discussion, nonetheless.[/quote]

I can’t for the life of me find this paper. It’s not on the website it claims to have been published on and Google isn’t being much help.

Can anyone else find it?[/quote]
You know what, same here. I think the author in the book screwed up. He named the article “Thermodynamic Edge For Low Carbohydrate Diets” in his book but that’s not the name of it, I think he took the name from here: Thermodynamic Edge For Low Carbohydrate Diets: SUNY Downstate Researchers Say All Calories Are NOT Alike

When I search on that website, the only article that comes up is the one that you mentioned that said had bad math or something, “A calorie is a calorie” violates the second law of thermodynamics".

[quote]PB Andy wrote:

I’m wondering if maybe the study was re-published as reference #4, “Thermodynamics and Metabolic Advantage of Weight Loss Diets” found here:

http://online.liebertpub.com/doi/abs/10.1089/154041903322716688

…which I can’t access as my university account only subscribes to that journal from 2006 on (I don’t know how that shit works but it’s total bull… do journals charge based on the amount of access they give to their archives, or something?)

It seems unlikely that that’s the case, but it’s just strange that a published article would fall off the face of the net like that.

Does anyone have access to the journal linked above so we can see what’s going on with that paper?

Hmm OK so I suppose I should have just Googled that paper before posting.

Here’s a link to it:

http://www.proteinpower.com/drmike/wp-content/uploads/2007/11/thermodynamics-and-metabolic-advantage-of-weight-loss-diets.pdf

I’ll probably be snowed in my apartment for most of tomorrow so I’ll take a gander at it then.

Gluck with that weather bruh. You guys are getting pounded.