Extremely Low DHEA-S But In-Range Testosterone/E2

Pharma / TRT Testosterone Replacement
1

Hi all. This is the closest related section I could post this. Would appreciate if anyone can assist or point me in the right direction.

I had these blood results taken earlier this year. I have a few questions, primarily around my very low DHEA-S levels. For context, I am a 27 year old male.

Follow up questions, are my testosterone levels alongside my estradiol readings any cause for concern?

Relevant numbers (I can find a way to share the full results if needed):

  • DHEA-S level is 2.7umol/L while the reference is 4.6-16.1
  • Free Testosterone is 501 pmol/L with reference 180-739
  • Estradiol 124pmol/L with reference 40-161

The only supplement/drug of note I’ve previously taken is MK-677 for a shoulder injury over lockdown. I do drink coffee (everyday) and chew nicotine gum (periods on and off for weeks at a time each).

I am open to seeing an endocrinologist, but am not convinced by doctors in my area. If you have any telemedicine options that are legally allowed to service international patients, that would be great too.

Thanks for any help!

2

Not sure I’d want to tamper with a Free Test in the better half of the reference range to be honest.

Why? If you can stop for weeks, you probably should just stop.

3

When talking about hormones, AR gene CAG repeats, long/short, determine how much hormone you need to feel normal. Someone naturally at 958 ng/dL with Free T above normal (2% of the population) now finding themselves at 500 ng/dL and midrange on the Free T may find they don’t feel normal anymore, because normal for them is at or above normal.

When a doctor is trying to determine normal status for you (<300 ng/dL), they are comparing your to everyone else without knowing AR gene CAG repeats or sensitivity to hormones. Imagine going to a shoe store and all shoes are sizes 10.5, same size shoe for everyone.

You will never get TRT from a sick care doctor because it will be tough to convince your insurance company that with these levels put you in a disease state which is the threshold for getting stuff covered by insurance or state healthcare systems.

The reference ranges are troubling,180-739, which makes me wonder is the sample population is 50-85 year olds.

It’s highly likely any symptoms are from the low DHEA and are not hormonal.