I’m sure he is a great dr (other than thinking estrogen doesn’t affect serotonin haha). He could just be a little more user friendly.
Fair enough. I can respect that.
Exactly and totally agree. People are too worried about how he posts on a forum and not the actual output of his work with patients.
People say “oh I’ll never use him” until they hit the flood hard and are sick and tired.
Pretty much everyone who doesn’t know him are throwing shade. I don’t see any of his patients on this forum asking for a second opinion or bashing the dude for being a horrible professional.
Unlike other doctors and clinics who are second guessed daily on this board.
hey I just want to say thank you for all the advice and information that you just provided. I first started out with Dr.Crisler and that was a struggling time of my life and I am still struggling till today. It has been 4 years and I have been through so much. I have been apart of 4 different clinics and still have not been able to find someone that can help me. This forum is the only place that I can escape to where I know people will understand how I feel. I pray all the time that one day someone will be able to help me because all I want is to get better. Im not here to lift weights or get strong or anything like that. I just wan to be able to keep a normal relationship and be in love with a healthy sex life like everyone else. I hate feeling sad because of how much this testosterone deficiency has changed my life. So it is very helpful when someone can maybe point me in the rite direction to someone that could possibly help me.
Everyone says that they read studies and do there on research along with using doctors.
where do you guys go to read up on the most recent studies and protocols on TRT?
Great questions. I’m curious to know as well ![]()
Guideline for Male Testosterone Therapy: A Clinician’s Perspective
https://academic.oup.com/jcem/article/92/2/416/2566759?searchresult=1
A Perspective on the Evolving Landscape in Male Reproductive Medicine
https://academic.oup.com/jcem/article/101/3/827/2804734?searchresult=1
Sex Hormones and Ischemic Stroke: A Prospective Cohort Study and Meta-Analyses
https://academic.oup.com/jcem/article/101/1/69/2806544?searchresult=1
Association of Sex Hormones With Sexual Function, Vitality, and Physical Function of Symptomatic Older Men With Low Testosterone Levels at Baseline in the Testosterone Trials
https://academic.oup.com/jcem/article/100/3/1146/2839968?searchresult=1
Endogenous Testosterone and its Relationship to Preclinical and Clinical Measures of Cardiovascular Disease in the Atherosclerosis Risk in Communities Stud
https://academic.oup.com/jcem/article/100/4/1602/2815133?searchresult=1
Weekly Versus Monthly Testosterone Administration on Fast and Slow Skeletal Muscle Fibers in Older Adult Males
https://academic.oup.com/jcem/article/100/2/E223/2814624?searchresult=1
Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men
https://academic.oup.com/jcem/article/100/4/1396/2815099?searchresult=1
Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients With Type 2 Diabetes
Bone Mineral Density in Young Women With Primary Ovarian Insufficiency: Results of a Three-Year Randomized Controlled Trial of Physiological Transdermal Estradiol and Testosterone Replacement
In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortality and Higher Dihydrotestosterone With Reduced Ischemic Heart Disease Mortality, While Estradiol Levels Do Not Predict Mortality
Testosterone and Progesterone, But Not Estradiol, Stimulate Muscle Protein Synthesis in Postmenopausal Women
Testosterone Treatment and Mortality in Men with Low Testosterone Levels
Low Free Testosterone Predicts Mortality from Cardiovascular Disease But Not Other Causes: The Health in Men Study
I like this one too
Testosterone and Cardiovascular Disease
http://www.onlinejacc.org/content/accj/67/5/545.full.pdf
From article above
UPDATE
So I had my initial consult with Mike. So far, really happy with Defy, but let’s see how long it takes the meds to get to me. He looked at my labs and said that my retired doc did a good job and agreed to continue my current regiment. I am supposed to do labs at 3 months again to see where I’m at, and then thereafter it’ll be labs every 6 months.
Will continue to update this thread as I progress along the whole process.
Yeah it’s really annoying. I have a call w dr Saya next week and am going to bring it up. Every time I ask for an update the answer is just that they’re within their 4-5 day window
Hey I was wondering if you have any updates about how things have been going ?
Hi ZSub,
My experience with them has been great and continues to be so I’ve had my second consult and second labs done with them and I am working with Mike P. who is a PA.
He’s been very responsive when I have questions, and I actually feel and look better than I do when I worked with my previous retired healthcare provider. There staff is always responsive via email, and they always call you back when they say they will.
The only complain that I have is that not all peptides are available as only one compounding pharmacy can ship to CA. But also, this is all theory, and there isn’t evidence, but when I got diagnosed with COVID, I felt that the Peptides played a significant role in my recovery (not saying it solved it).
Mike P. also doesn’t try to sell you the pony. He gives me two options, one he thinks I should take which is always the lower costing option and then one he that is higher. So example is when I started on Peptides. He said to start on MK-677 after listening to my needs, but warned of potential water retention and hunger (which is a no-go for me, as I already like food too much already). He then said I could try semorelin only, but I did my research and opted to do a semorelin and ipamorelin combo. But the $330 was not sustainable, so he suggested maybe cutting the dose in half and mixing the two, so .25 of Semorelin and Ipamorelin. After being on peptides, I am starting to see abs, which I NEVER have in the 38 years of my life. I’ve always exercised and ate pretty clean (minus the occasional cake, cookies and ice cream).
Overall, I would recommend people to Defy, so far I haven’t had a bad experience with them and the cost is significantly cheaper for me at least. Overall, I’m paying maybe $250 a month with everything (Test, HCG, BVitamin, Glutathione, Lipo-C, Semorelin and Ipamorelin) which is a steal! I use to get “Fat Burner” injections for $35 a pop every week, and being able to buy them at Defy has been a huge money saver.
I definitely will update this post if I encounter any bad experiences.
200 twice per week to only 1100 TT?
Any side effects from clomiphene?
I always thought TRT would work better than antidepressants for a lot of men.
TRT is a way better alternative to treating depression.
Before all of this my labs were in the high 300’s/200’s. I was on 3 anti-depressants at the same time and I felt like a zombie. Only until my last doctor who retired was pushed me to try TRT. LITERALLY a life/game changer.
Great to hear.
No vision side effects from the clomiphene?
This is the thing I don’t understand why testosterone related services is so expensive your don’t see people with high blood pressure paying this much money. Testosterone it’s self is not even that expansive so why do places charge so much? It’s all a business smh. $250 a month is a car note if you do the math that $3,000 a year and $15,000 in 5 years. I don’t understand why this is so expansive
It’s a money machine man. And TRT is usually for life. So if a clinic gets you in for $250 every month, times thousands of patients, it’s like printing money
brb opening an anti-aging clinic.
Remote work means almost no overhead, >$100/mo from 1000 patients, 1.2MM/y.
With the current state of treatment protocols and ignorant doctors in sick care, one reason, demand. You are mostly paying for experience and knowledgeable doctors, generally the test and HCG are cheaper than labs and consultations.
Some of these walk-in clinics charge outrageous prices, sometimes hundreds of dollars before medicine and labs come into the picture.

