Exemestane - how long to work? TRT

Pharma / TRT Testosterone Replacement
1

Hi everyone

44 year old TRT patient here.

Always impressed by the knowledge on the forum and looking for some advice / reassurance.

TRT regime is 15mg Test C daily by SC injection. Estradiol sitting at 196 last bloods - Dec. Test was like 22.

I suffered with high EO and had aramotase twice a week and felt lousy but my EO came down to 82 in May. I don’t know what my baseline is as the clinic never checked it.

When I have high EO my principal symptoms are erectile dysfunction so even though I get aroused, my penis is rather flaccid and orgasms feel rubbish. When Aramotase did its job that went away.

I changed my regime to daily subcut and lower dose to not spike the EO and over the last six months the EO has crept back up.

So I have started Exemestane 6.25mg every Friday (quarter tablet with a pill cutter so pretty sure getting a quarter). No side effects at all (result) but limited response after six weeks. The clinic did suggest I up my test-c dose from 15mg to 20mg a day immediately before I started to AI and so I guess its needed to play catch up, last week I reduced my test-c back to 15mg a day.

I’m not tired, feel mentally good, have energy etc but my ED persists and I’m sweating at night and putting some weight on.

Any ideas how long exemestane takes to bite? Any further advice.

With the ED I had low T for ages and that killed my erectile function, it has been really good when the balance of T and EO has been OK but I wonder if the repeated hormonal hits have meant that I’m stuck with ED now and should try himms or some other ED treatment.

All my other bloods are absolutely spot on and I don’t smoke or drink alcohol. My BMI is 29.

2

I would want to see your TT, FT, and E2 sensitive in one test with lab ranges to make comment. You don’t make two changes at once… ever. If you do that you won’t know what the problem is. So you can either adjust your T dose OR add an AI but never both if you want to solve a problem.

3

Hello

The Test went up about 10 days prior to starting exemestane.

Most recent bloods before starting exemestane:

Estradiol 192.3pmol (41-159)

Free Test 0.669 nmol/L (0.155-0.593)

Testosterone 26.969 nmol/L

SHBG 26.64nmol/L

DHEA-S 14.7nmol/L (2.4-11.6)

4

Ever tried just dialing down your dose for a bit? No E2 control? Your T levels are off the charts too.

5

Hi

When those bloods were done that was the lowest my testosterone has been since I started TRT!

I used to have test-c 60mg twice a week but this made me irritable after injection day so changed to everyday.

Clinic here in the UK seems to know what they are up to I think.

When I had anastrazole for a few months my results were

Estradiol 86.6

FT 0.801

Test 32.8