Excess Testosterone

At last I’m saved, Baptize me great ones of T-Nation…

Alright, now that that’s over with, I have a question about testosterone. I wasn’t sure where to put this, so I figured supplements would be the best place as it’s related. What happens to excess testosterone when you’re on a Estrogen suppressor. I searched around on the net, and tried to use the search function and that’s not working for me for some reason. I haven’t found any information on what exactly happens to excess T if it can’t turn into Estrogen by Aromatase. (Sp?) Any help and insight would be greatly appreciated.

[quote]AkiraMusashi wrote:
At last I’m saved, Baptize me great ones of T-Nation…

Alright, now that that’s over with, I have a question about testosterone. I wasn’t sure where to put this, so I figured supplements would be the best place as it’s related. What happens to excess testosterone when you’re on a Estrogen suppressor. I searched around on the net, and tried to use the search function and that’s not working for me for some reason. I haven’t found any information on what exactly happens to excess T if it can’t turn into Estrogen by Aromatase. (Sp?) Any help and insight would be greatly appreciated. [/quote]

Some is excreted unchanged, some is 5 alpha-reduced to DHT, some is oxidized to a 17-keto metabolite, while also being reduced at the 3-keto. Some of these metabolites are then also conjugated (i.e., sulfated and glucuronidated) for renal excretion. Essentially, with the exception of the 5 alpha-reduction, the metabolism is done to increase hydrophilicity and thus make urinary excretion much easier. I’d like to emphasize that this hepatic metabolism is most certainly not unique to testosterone but just about any lipophilic compound.

Thanks for the info. So from the sentence or so that I understood, I think I pee(and crap) it out. I’m going to look up everything you said to actually understand it.

[quote]AkiraMusashi wrote:
Thanks for the info. So from the sentence or so that I understood, I think I pee(and crap) it out. I’m going to look up everything you said to actually understand it. [/quote]

Yes, you’re right on both. Also, I kind of did you a disservice there as I didn’t mention that the oxidation at the 17-OH and the reduction at the 3-keto are both also done to make the testosterone inactive, biologically speaking. It’s after this that a few specific metabolites of those processes are conjugated and made more hydrophilic or water soluble for renal excretion.

Hope I was of some help.

[quote]Cy Willson wrote:
Some is excreted unchanged, some is 5 alpha-reduced to DHT, some is oxidized to a 17-keto metabolite, while also being reduced at the 3-keto. Some of these metabolites are then also conjugated (i.e., sulfated and glucuronidated) for renal excretion. Essentially, with the exception of the 5 alpha-reduction, the metabolism is done to increase hydrophilicity and thus make urinary excretion much easier. I’d like to emphasize that this hepatic metabolism is most certainly not unique to testosterone but just about any lipophilic compound.[/quote]

I consider myself a fairly intelligent individual. I actually understand and enjoy philisophical logic. I devour books like they’re going out of style. I recently printed a picture from “Revenge of the Nerds,” titled it, “Join the Club,” and posted it in my office.

Then I read one of Cy’s messages.

Cy, it’s only natural to assume that you have a PhD (please correct me if I’m wrong). In what subject did you major? Or am I truly just an idiot?

[PMiller humbly retreats to his cave, dragging the knuckles of one hand while scratching his melon with the other. Ugh.]

Wow Cy, you make that look fun and easy. Like a pro snowboarder ripping down a mountain with an avalanche chasing, only to wrap up the run by expertly whipping a few quick cuts then comming to rest, with the avalanche off to the side,and a nice runnout in front of him. Too bad that when I try that I get burried.

[quote]PMiller wrote:
Cy Willson wrote:
Some is excreted unchanged, some is 5 alpha-reduced to DHT, some is oxidized to a 17-keto metabolite, while also being reduced at the 3-keto. Some of these metabolites are then also conjugated (i.e., sulfated and glucuronidated) for renal excretion. Essentially, with the exception of the 5 alpha-reduction, the metabolism is done to increase hydrophilicity and thus make urinary excretion much easier. I’d like to emphasize that this hepatic metabolism is most certainly not unique to testosterone but just about any lipophilic compound.

I consider myself a fairly intelligent individual. I actually understand and enjoy philisophical logic. I devour books like they’re going out of style. I recently printed a picture from “Revenge of the Nerds,” titled it, “Join the Club,” and posted it in my office.

Then I read one of Cy’s messages.

Cy, it’s only natural to assume that you have a PhD (please correct me if I’m wrong). In what subject did you major? Or am I truly just an idiot?

[PMiller humbly retreats to his cave, dragging the knuckles of one hand while scratching his melon with the other. Ugh.][/quote]

Nope, no Ph.D. I’m in a Pharm.D. program, but also have a decent amount of credits which should I decide to go back, could be applied to the graduate studies program in pharmaceutical science. For undergrad I majored in biotechnology and minored in chemistry.

Much of what I discussed above is something any student taking a graduate level pharmacology or toxicology course would have had to become very familiar with so it’s nothing really special.

So, no you’re not dumb and I’m not the smartest man on Earth. It’s merely terminology and memorization of taught pathways of metabolism.

I just got done watching Battlestar Galactica. I just noticed a disturbing congruence.

Note Cy’s machine-like efficiency whipping out strings of almost intelligible terminology. Also note the word “Cylon”.

I leave the conclusion as an exercise for the reader.

Cy, it’s a lot easier to make up stuff when no one knows what you’re talking about, right? lol

Cheers

[quote]David Barr wrote:
Cy, it’s a lot easier to make up stuff when no one knows what you’re talking about, right? lol

Cheers[/quote]

Right on Dave! It’s odd you mention that and makes me think you have my phone tapped as I did that just this morning. My girlfriend asked me why she feels nauseous every time she drinks hot tea in the morning on an empty stomach. I have the same thing happen and imagined it simply had something to do with drinking a hot beverage on an empty stomach, but really didn’t have much of an answer, so I told her it’s a classic symptom of a disease called “pa-gina-itis”. Three “yeah right…are you serious” questions later, she actually believed me.

The Cylons look like humans now…

[quote]AkiraMusashi wrote:
At last I’m saved, Baptize me great ones of T-Nation…

Alright, now that that’s over with, I have a question about testosterone. I wasn’t sure where to put this, so I figured supplements would be the best place as it’s related. What happens to excess testosterone when you’re on a Estrogen suppressor. I searched around on the net, and tried to use the search function and that’s not working for me for some reason. I haven’t found any information on what exactly happens to excess T if it can’t turn into Estrogen by Aromatase. (Sp?) Any help and insight would be greatly appreciated. [/quote]

What is the meaning of the first two sentences of your post?

[quote]ZEB wrote:
What is the meaning of the first two sentences of your post?
[/quote]

Yeah, I was thinking the same thing. A little bit cryptic, to say the least. I take it this is your first post or so on T-Nation?

Kuz

Yes, you’re right on both. Also, I kind of did you a disservice there as I didn’t mention that the oxidation at the 17-OH and the reduction at the 3-keto are both also done to make the testosterone inactive, biologically speaking. It’s after this that a few specific metabolites of those processes are conjugated and made more hydrophilic or water soluble for renal excretion.

Hope I was of some help.[/quote]

Thanks. Now it makes sense, whereas after your first response I think most of us were left scratching our heads and wondering about the impact on the 17-OH.

DB

Yeah, it was my first post, and from my experience of first posting on another message board, I expected to get a royal hazing by the powers that be. I guess I don’t have to worry about that or, someone will just sneak up on me with a sock full of doorknobs.

As for being a Pharm student, I’m majoring in History, I call tell you all about Rome, but deciphering Alpha 3.14-Dzxbua^3/4i is a dangerous forbidden realm that I have yet to tread on. Thanks for info though and I’m still reading up on “Renal Excretion of Testosterone.” =-)