Here’s my protocol:
1 mL (compounded) t-cyp per week (SubCutaneously)
400 units Pregnyl twice weekly.
0.5mg Arimidex twice Weekly.
I can also FEEL the high Estradiol affecting my daily life. Constant mood swings, easily angered over nothing, suspiciousness - generally very short-tempered.
Also, just like user “Sanelb” - I’m having serious trouble finding a place to safely perform a therapeutic phlebotomy. Defy is located in a very libertarian state. I do not.
HCG stimulates the testicles to produce testosterone and estrogen inside the testicles, circulating testosterone in the blood stream will convert to estrogen from aromatase in fat tissue, so sources of estrogen being made are created in two different locations.
Aromatase inhibitors can only block estrogen outside the testicles, and not estrogen made inside the testicles. No amount of Arimidex will lower E2 inside the testicles.
You must decrease the hCG dosage if you want to lower estrogen inside the testicles.
OK. You mentioned using “1 ml” test per week. Are you using 50mg, 100mg, 200 mg…?
What are you test levels?
59 is not “wicked high”. Everyone is different. Dont expect to raise your testosterone and then not get elevated E2. This is natural. As test increases, so does E2.
Outside of gyno, I would not recommend Adex or any other inhibitor, based on experience. My E2 was over 100 and without any sides, I took Adex for a few weeks which dropped E2 to 60 which in turn caused massive joint issues for me. It took me a month or so to get back feeling well. Lesson learned: high E2 is not necessarily bad especially on high levels of T. High E2 is also not necessarily the culprit of the sides you are experiencing - it might actually be too LOW E2 from the aromatase inhibitors
my e2 is 70 and I feel fine. but anytime I play with higher T doses (for me above 250/300 or so) I get those ‘mood’ issues. your pregnyl is also at a fairly low dose, i started to have e2 issues at 3000IU weekly. I would guess that you need to inject more frequently, maybe 3x as a start and observe
Systemlord,
I understand your point. Just so you know - 400 units twice per week was Defy’s own exact directions. What would you recommend I reduce the Pregnyl dosage down to?
Systemlord - my MORE PRESSING problem is of course my elevated Hematocrit and Hemoglobin. Here they are:
I spoke to Defy on the phone, and they even sent me a written prescription to take to any “blood center”. So I took it to my local blood bank - but the blood bank said they only work with cases involving “hemachromatosis”. But since my prescription said “polycythemia” - they said that is a condition they are “not trained to work with” (Sounds like red-tape bullshit if you ask me). So they told me to call their boss doctor in some central office - and he told me to go to my local hospital because only the hospital can work with polycythemia-related therapeutic phlebotomies. I went to my hospital as he said - I showed the lady my prescription - she booked me for next Wednesday for the phlebotomy.
So why am I complaining? Because simple tasks like taking a shower are harder because they cause more shortness-of-breath, body pains, and nausea.
Last year (2022) I also had high Hematocrit/RBC/Hg. However, my blood bank simply didn’t ask or even care about my hormones. So last year I was easily able to squeeze in TWO regular blood donations. After them - I noticed that my arm sores (from any blood test) would heal up in 25% the time it took withOUT any donations at all! Even my Estradiol went DOWN to acceptable levels simply from those 2 donations! And now they’re forcing me to walk around with such a high risk of stroke and heart attack.
You say my pregnyl is too low. Systemlord says my Pregnyl is too high. Hard to trust anyone these days. (No offense to you!) I was just referring to the current state-of-affairs in the Medical community these days.
Elevated, but you’re likely just dehydrated. Those values are heavily influenced by water intake. Labs first thing in the AM are likely to be higher than usual
SystemLord,
I’m actually much more interested in your claim that Pregnyl (by itself) can actually increase Estradiol synthesis - adding to a “false high reading” of total system Estradiol on my blood test.
These hematocrit and hemoglobin levels aren’t a problem. Mine are very similar and none of my doctors aren’t freaking out.
Erythrocytosis is NOT polycythemia! This is the most misused word, misunderstood condition, in western medicine. The only way you could know if you have polycythemia is getting a JAK2 mutation gene test.
TRT induces erythrocytosis, the same condition people in Boulder, Colorado experience at high altitude. The 50, 51, 52 and even 54% labs cutoffs are arbitrary.
There’s no evidence to support thicker blood causes strokes or heart attacks, pure myth. The available data shows the exact opposite.
We observed that increasing erythrocyte concentrations inhibited profoundly and reversibly thrombus formation and prolonged the time of clot development, most likely due to mechanical interference of red blood cells with clot-forming platelets. Transgenic animals showed increased nitric oxide levels in the blood that could inhibit vasoconstriction and platelet activation. Finally, we observed that plasmatic coagulation activity in transgenic animals was significantly decreased.
Results: A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High altitude populations (HAP) had lower stroke mortality in men [OR: 0.91 (0.88–0.95)] and women [OR: 0.83 (0.79–0.86)]. In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men [OR: 0.55 (CI 95% 0.54–0.56)] and women [OR: 0.65 (CI 95% 0.64–0.66)].
Conclusion: This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000 and 3,500 m.
