E2 Level Control

My estrogen was high already despite AI. See OP. Decided to continue it on a low dose for 4 weeks until new bloods or back acne improved.

As it stands neither of these has happened.

P.s 5’11 and 13 stone in decent shape.

46 pg/mL is not high @ T of 2072 ng/dL As a matter of fact I would say that that is pretty low for that high of T. Personally my back acne kicks in whenever I change doses regardless of coming up or down but was persistent when my T was around 2k total. It may just be your body adjusting to the new lower dose.

I wouldn’t change your AI at all. If you have a good libido , rock hard wood and waking up with morning wood - DO NOT CHANGE YOUR AI.

Based on your labs the TT:E2 ratio is fine ( further backed up by the good libido and hard wood ).

Do not try to change your E2 numbers based ONLY on the number.

Now to the acne. I would bet serious cash this is due to the wide fluctuation during the week in T levels ( and maybe E2 ). If you inject 1x a week you are getting a MASSIVE spike followed by a ride downward. Most peoples bodies don’t like this, and some peoples bodies REALLY don’t like this.

I would do 100mg , split to 50mg 2x a week. You will need to be on any new protocol you come up with for a minimum of 4-5wks so your body can level out and get used to it before you start to evaluate all the side effects.

As a final note I would never recommend a guy use an AI unless he had high e2 systmtoms matched with high e2 numbers.

  • depression
  • low libido
  • up and down wood ( comes on, goes away, comes back )
  • no wood
  • zero morning wood or very rare
  • lots of water weight
  • gyno

You don’t have any of these symptoms so the e2 number you posted should not be “chased” down and modified solely because it doesn’t fit within some 20-30 range all the bros have decided is the best amount. That 20-30 range was widely passed around and taken as the de-facto standard because if you measure a few hundred NORMAL NATURAL guys ( whos TT is probably 500-700 ) then 20-30 e2 numbers ( pg/ml ) is fine. But when your T level is 2000+ then a number like 40 or 50 might be fine depending on the individual. Hence why you have to combine both symptoms and the number to determine action. If my e2 was 500 but i had zero high e2 side effects and felt great then I wouldn’t take an AI even if the doctor jumped on the desk.

Update

Recap: Was on 200mg Cyp - 1 x pin a week. Suffered bad back acne. Switched to 100mg Sus 1 x pin a week. Maintained 0.25mg Anastrozole throughout.

Dec 18 labs

*TESTOSTERONE 72.1 nmol/L 8.64 - 29.00

*17-BETA OESTRADIOL 170 pmol/L 41.00 - 159.00

Have received new labs after 4 shots (4 weeks) of Sus

Jan 19 labs

TESTOSTERONE 28.6 nmol/L 8.64 - 29.00

*117-BETA OESTRADIOL 28.3 pmol/L 41.00 - 159.00

I think the Sus is dodgy. Back acne still the same though! Sex drive, wood, concentration and mood still high.

Back onto the Cyp for now - will go onto 50mg x 2 x week for 100mg / week total for 4 weeks and then get new labs.

Am so glad I get labs or would be heading for a crash and be clueless as to why. Would have probably ended up taking even more AI and crashing harder.

You continued with the same AI after cutting your T dose and drove your E2 from 46.3 pg/mL down to 7.6 pg/mL? Thats a pretty hard fucking crash dude.

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I’m guessing your back acne has nothing to do with your E2 and actually due to your DHT levels.

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Yep. I kept the AI the same as I was suffering with acne and hoped a E2 reduction would help. I reasoned there was a crossover as the cyp was lingering in my system, and I would re-adjust AI based on labs.

Still sounds reasonable to me… however clearly it wasn’t :slight_smile:

Like was mentioned by several members when you change protocols you can sometimes expect sebaceous activity to ramp up for a little bit until your body gets used to it. I wish you luck digging out of this hole. Tread lightly with training.

I’m guessing your back acne has nothing to do with your E2 and actually due to your DHT levels.

I would have hoped to have seen a reduction as my T level has shelved. It is still just as bad. I do agree it doesn’t seem to be E2 though.

I am not sure I am in a hole - at least yet. I feel really good and training is going well. Maybe I have further to fall who knows.

I acknowledge the settling in time. Perhaps I am too impatient:-\

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I would think now that your T has lowered it will start to clear but not until after you start to stabilize more. That is just my guess though.

Am I missing sg here, or 200 mg/week really got you to 72 nmol/L T (=2080 ng/dl)? :open_mouth:

In this well-known study (https://www.physiology.org/doi/pdf/10.1152/ajpendo.2001.281.6.e1172) 300 mg got them to ~1.300. It took 600 mg to take them to 2,300 ng/dl.

Unless the contents of the bottle don’t match the label, yes.

Wasn’t aware this was unusual.

I was on 180mg T-Cyp (90mgx2 weekly) and midway through shot cycle was at 1965 ng/dL.

You guys seem to get some good shit :wink:
I was almost at the same level with 400 mg. To be more on-topic, the same test also revealed an E2 of 80 pg/ml. So, I guess some of the T had been wasted into E2, but I doubt that explains everything.

Its Rx.

From September on 90mg x 2 a week:
ESTRADIOL, ULTRASENSITIVE LC/MS/MS 54 Range <OR = 29 pg/mL

TESTOSTERONE, TOTAL, MS 1965 Range 250-1100 ng/dL

TESTOSTERONE, FREE 414.6 Range 35.0-155.0 pg/mL

I was on a little over a mg of anastrozole a week but won’t take next time I up my dose.

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GET SOME!!!

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Yes apparently I respond very well to T.

I have spoken to the lab who are going to redo the test for free. Will see mid week of results are the same.

This went to the wrong post weird.