Actually seems really pretty promising.
Who would want to bet that Biotest will be looking into this and trying to come out with their own HMB-FA supplement? I’m not sure if Micro-PA just releasing would deter them looking into it or not, but I know I’d like to see a Biotest HMB-FA
[quote]Trevorxgage wrote:
Actually seems really pretty promising.
Who would want to bet that Biotest will be looking into this and trying to come out with their own HMB-FA supplement? I’m not sure if Micro-PA just releasing would deter them looking into it or not, but I know I’d like to see a Biotest HMB-FA
[/quote]
I’d like to see a Biotest Agamatine with their delivery system. But yeah this looks interesting
This combined with micro PA could be awesome. Both increase mtor
[quote]cally wrote:
This combined with micro PA could be awesome. Both increase mtor[/quote]
Yeah, I was thinking the same.
What is good about this study is that it uses a longer-term time frame relative to other studies on HMB. I know HMB has been shown to increase the mTor pathway in rats, and improve protein synthesis in at least two studies (although one study found HMB increased protein synthesis by 70% while the other noted a trivial increase in muscle mass over 9 weeks and did not control for caloric intake). Another study found no effect on protein synthesis of HMB in the standard calcium salt form.
From what I’ve read HMB is much more anti-catabolic than Leucine but Leucine is more anabolic, which makes me wonder how a trainee would use HMB and Leucine supplementation.
This applies broadly to other supplement studies and I guess scientific research in general, but why is there such a variation in results? Is it to do with differing methodologies, sample populations, measurement accuracy and/or weak monitoring of controls?
I thought HMB was considered almost completely BS by now. It had a lot of hype in the 90s but never really worked for anyone AFAIK…
Looks like the HMB group gained 1.5 lbs/wk of LBM while losing fat for 12 weeks. Sounds otherworldly. Also looks like the study was written in part by the HMB patent holder… hmm.
The pathway is opposite of protein synthesis, HMB acts similarly to insulin during the muscle building process. If you spike insulin during working out with a carbohydrate/protein peri/intra/post work-out etc, insulin will inhibit the Foxo1 pathway which leads to stopping protein degradation. HMB at supposedly 3 grams will also inhibit this pathway. Perhaps HMB-FA is a more potent form that works better than regular HMB. I’m totally guessing at this.
Im curious if Biotest has anything in the pipeline with this ingredient since they seem to work with Dr. Wilson. It seems as though another large company will be coming out with this ingredient in their line very soon. Id prefer to get it from here however. Combined with Micro PA could be an amazing stack.
[quote]fightnews wrote:
I’d like to see a Biotest Agamatine with their delivery system. But yeah this looks interesting[/quote]
That’s silly, agmatine does not have bio-availibility issues 
[quote]kgatch3 wrote:
The pathway is opposite of protein synthesis, HMB acts similarly to insulin during the muscle building process. If you spike insulin during working out with a carbohydrate/protein peri/intra/post work-out etc, insulin will inhibit the Foxo1 pathway which leads to stopping protein degradation. HMB at supposedly 3 grams will also inhibit this pathway. Perhaps HMB-FA is a more potent form that works better than regular HMB. I’m totally guessing at this. [/quote]
From my understanding, HMB-FA and regular HMB has a big difference in the way it ends up saturating your system. Non-FA will eventually make it all through into your system but HMB-FA allows for a bulbous dose to saturate your system, it would seem that the saturation here matters.
Doing a little more research, this was actually discussed a year ago on the boards. And I mentioned the wrong pathway, it’s the FOXO3A pathway.