Dopamine Agonists Affect LH

Pharma TRT
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I read this article from 1998: Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells - PubMed that claim that dopamin agonist can increase the risk of leydig cell hyperplasia and lower LH, testosterone and increase aromatase activity (increaee estrogen). Is this true for dopamin agonists in general, or only the specifik ones they used in the experiment (mesulergine)?

”the dopamine agonist also increased aromatase activity in the Leydig cells and thus the potential to produce estrogens”

”is concluded that treatment of rats with the dopamine agonist indirectly (i.e., via the pituitary) affects Leydig cell function resulting in a rapid decrease in LH receptors and cAMP and testosterone production. Aromatase activity is increased and thus the capacity to produce estrogens.”

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Interesting article. I think i read that one over a couple weeks back.

I’m taking a low dose dopamine agonist, ropinirole. Trying to increase libido.

Dopamine agonists are prescribed off label to increase sexual functioning as well as help with erections.

I started a few days back, and am titrating up to a higher dose eventually. I had started a thread on here that I will try to update here and there if you’re interested.

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Never experienced this, but I’ve also not used a DA agonist without also being on TRT.

Is this caused by the increase in DA? Or the meds themselves?

I’m guessing you’re taking (or considering taking) a DA agonist now?

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I suffer from hyperprolactinemia and will maybe treat it with a dopamin agonist in the future. I don’t know which kind of dopamin agonist yet, so I want to find out as much as possible. Pros and cons. What’s weird though is that my LH is raised and my FSH is high, not typical for hyperprolactinemia.

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What I’ve read about dopamine, is that it increase testosterone and LH, and increase behaviour that is associated with high testosterone. Dopamine make you feel motivated, confident and energized. When dopamine goes up testosterone goes up, and vice versa. The Dopamine and Testosterone Relationship - TestoFuel Blog

That’s why the article surprised me. On wikipedia you can read this about Mesulergin (one of the dopamin agonist that was used in the experiment) ”further development was halted due to adverse histological abnormalities in rats.” Mesulergine - Wikipedia

It seem to me that the effect on LH, testosterone and aromatization was side effects of these specific dopamin agonists, and not dopamin agonists in general. But it’s very hard to find any information about it, and the effect of different dopamin agonists. I will follow your tread about ropinirole though and in the future maybe I’ll start taking a dopamin agonist too, so I want to find out as much as possible about them and which kind that’s preferable.

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Try some cabergoline for that. See if you get a response. Although you shouldn’t run cabergoline long term. You’d want a non ergoline DA.

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Swoops

Which DA have you tried?

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What’s your PRL at?

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Just Caber and P5P. I’ve dropped both now, every so often I add in .125mg Caber with mixed results

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I’m under the impression caber only works IF you have elevated prolactin. It’s not heart healthy at all, long term. The non ergoline DAs are more safe from what i understand.

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I’ve heard the same too. I was trying to see if I could get to the perfect dialed in spot with a small dose, but I don’t think I really need it after all

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2760 mIE/L (range: 65-405)

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Is there any reason why ergoline agonists like cabergoline and bromocriptine are the mainstream options when treating hyperprolactinemia? Can a non-ergoline DA be used to treat hyperprolactinemia?

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That would be a question for a dr. Not sure. I just know the older DAs were ergoline… the newer/safer ones are Non.