Doesn't the "Honeymoon Period" Argue for Higher T Levels?

[kamuela]

@oppenheimer

Has to do with receptor density changing. It also has an impact on dopamine. Once the body senses a very high level of a compound, it will downregulate the # of receptors expressed on cell surfaces.

Really low chemical signal? Build a shitload of receptors to “pickup” every signal floating around.

Swamped with chemical noise? Get rid of the receptors and downregulate the intense signal.

Homeostasis is always reached, but some peoples homeostasis sucks, because of the downstream pathways that are affected.

I felt “alive” for 1-2 months on 120mg/week. Felt like life was worth living, erections were amazing, sex drive was insane. Lifting was amazing. Now I feel more depressed and more anhedonic than before TRT.

Good points!
Thanks!
k.

[dixiewrecked]

This thread seems to imply benefits of less frequent injections.

[kamuela]

Wondering if the right HCG dosage (in addition to TRT) might rekindle the “honeymoon period”, or at least a revisit … . . . .