[quote]shizen wrote:
it took down link showed about protective/beneficial effects of dnp so here it is
'I think it’s admirable that you would recognize your lack of knowledge in this area and ask for more information. It’s what any true philosopher (lover of wisdom) would do.
Here are a few random studies I just pulled out of my bookmarks. I’ve given a quick explanation if it’s questionable what the point is:
Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus.
http://www.ncbi.nlm.nih.gov/entrez/q…_uids=16754295
This landmark paper obviously made an effort to change the widespread misperception that DNP is only dangerous and toxic It points to protective effects in the brain, possible treatments for neurodegenerative diseases like Parkinson’s, and even extension of lifespan.
The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia.
http://www.ncbi.nlm.nih.gov/entrez/q…=pubmed_docsum
This is one of many studies showing that DNP is protective in models where blood flow is interrupted (stroke, heart attack) and then restored. Usually there is a massive release of oxidative stress when this happens. DNP greatly limits this.
Regulation of human male germ cell death by modulators of ATP production.
http://www.ncbi.nlm.nih.gov/entrez/q…=pubmed_docsum
This study shows that DNP prevents germ cell apoptosis (death). This is the same thing testosterone does. When apoptosis is accelerated, you get all kinds of fertility problems. Looks like DNP may actually help here, depending on the mechanism behind the irregular apoptosis.
Energy requirement for degradation of tumor-associated protein p53.
http://www.ncbi.nlm.nih.gov/entrez/q…=pubmed_docsum
p53 is a transcription factor recognized as having anti-cancer effects in cells. There’s only good news here with regards to DNP, as DNP has been shown to increase p53 expression. This has been shown both directly in this study and also via AMPK, which DNP clearly activates. AMPK is likely the mechanism through which DNP exerts this anti-cancer effect.
The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord.
http://www.ncbi.nlm.nih.gov/entrez/q…_uids=15672630
This paper showed that pretreatment with DNP significantly reduced the damage from a bruising injury to the spinal cord. Again, this has to do with a reduction in oxidative stress.
This is just a handful of dozens of papers. There are more showing positive effects on mitochondrial stability, prevention of atherosclerosis, and all sorts of other things that natural uncpupling proteins are involved in. Just jump on pubmed and look at related papers. '[/quote]
This is further evidence of your complete ignorance with regard to science. None of those links work, but from the titles I’ll just point out a few key points.
Are you about to have a stroke? In the immediate future? What about a heart attack? Since the answer is probably no, what use is any beneficial effect under these SPECIFIC, LIMITED and UNUSUAL biological circumstances? The answer is none whatsoever. Unless of course you are suggesting that people at a high risk of heart attach or stroke add some DNP to their statins. It is totally irrelevant to the average user.
DNP prevents apoptosis of germ cells. WOW. So whilst it is poisoning your reproductive system, and rearranging your gamete DNA, its keeping your germ cells alive and well. That’s an excellent benefit right there. DNP is a MUTAGEN. Look it up. Mutagens are also commonly carcinogens, but DNP has not been assessed in this capacity.
Do you know what protein p53 is and how it suppresses tumor formation? If you knew, you’d realise that it does so by PREVENTING MUTATIONS. Now here’s some elementary logic for you. If DNP is shown under experimental conditions to be a known mutagen, which is the dominant effect? Its’ ability to cause mutations of course, which means that any up regulation of p53 is incidental.
And finally DO YOU HAVE A CONTUSED SPINAL CORD? ARE YOU ABOUT TO GET ONE?
I think you have a contused brain.