That much arimidex crushed my e2 to below readable levels. If he absolutely has to take arimidex he should start with only 1/4 of a pill IMO. As I said earlier though he just stopped the AI 4 weeks ago that had crushed his E2 and his body is still adjusting from the change. It may come down on its own if given the time. If it doesn’t then he has other options, like injection frequency, that may help rather than adding another drug. An AI IMO should only be used as a last resort.
He can go with a smaller dosage. He just needs to stick with something for a period of time and then evaluate the situation.
Everyone is different. I also take hcg, so not sure how much that matters. I’m also 6’5” 220 lbs, not sure if that matters either.
0.25 mg 2X a week would probably crash me. If I needed to take it, I would dissolve it in vodka at a known concentration, then I would dose at about 0.1 mg per dose.
Yeah for sure he possibly could go with a lower dosage. Not sure what his free t is, and with lower SHBG may very well be higher just as his E2 is. Which would give room to move. Based on his total t being 696 which for some is still too low I was thinking frequency instead, so smaller injections but same total amount. I agree he shouldn’t change anything for a month though after labs are taken. That includes taking an AI.
If your E2 is still higher with 1.5mg of AI, that tells me that the HCG is doing a good job at stimulating your balls. From what I understand an AI won’t stop aromatization there
It does me as well. I was saying 0.25 once a week and that would be the max I would recommend until you knew how it affected you. I would rather him try anything other than an AI though.
I am not sure if placebo, or possibly caused by other things (I can’t think of any other changes), but it seems that after stopping AI, I came out of depression, and anxiety. Again, not sure if it could have been something else, but I have noticed an improvement in mood after stopping.
I have looked up the sides of anastrozal, and depression is a side. Might come from low E2 not the AI, but I am feeling better.
Thought everyone was crazy with the no AI stuff, but I was down for a couple months, and figured other people say dropping the AI made them feel better, so I gave it a try.
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I did not see a large difference but definitely was an improvement. I can’t neccesarily put it on stopping the AI though as I also moved from cream to injections at the same time.
I guess I also lowered HCG, so that could definitely be part of it.
I guess I was not thinking of that at the first post. I have also heard that HCG can cause mood issues. I went from 300 iu 3X per week to 150 IU 3X per week.
My free T hasn’t been checked but historically pre-treatment my free T has always been either low or on the low side of normal. Anyways I agree with everything you’re saying, I’m definitely going to wait it out and see what happens in another month.
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HOly shit…I had an endo tell me exactly the same thing.
Just came across a fascinating research study.
Here are some key things I read:
“In healthy young men, aromatase inhibition lowers plasma E2, and this decrease is associated with decreased flow-mediated dilatation of the brachial artery”
“with the best CEVD (cerebrovascular disease) protection having at T/E2 ratio of 0.13–0.15”
“the significant effect of T/E2 also reflected the fact that increased SHBG, increased aromatase inhibition, higher TT, lower E2 and other factors that change the TT/E2 ratio might all contribute to the increased CEVD incidence. The balance between these two hormones may be more important than their absolute quantities, which partly explains why studies focusing on androgens or estrogens alone have produced inconclusive results”
A lot of you have been telling me this already but in these forums you have different people saying different things…it’s nice to see concrete evidence in a study…hopefully it will help give clarity to those that may come across this thread looking for answers.
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Very interesting. And backs up what some have been saying here