I’m using Tren A for the first time. Started low and moved up to 210 mgs wk. I had a few bad mood days so I cut it for a week. reintroduced it at 105mg, just moved up to 140 mg. If mood stays level then I’ll go back up to 210 again. I pin everyday, and pin Test C and Tren A in same needle. I don’t have any side effects at this dose. No cough, minor libido decline, nothing else. I don’t find it particularly harsh. I like it better than NPP which I couldn’t do more than 2 wks without anxiety. I started Ace because of the shorter ester. I would do tren E in the future so I can pin less if I finish this cycle with no issues. So, my two cents is that AAS affects every one differently, you may like it and have no issues but always start conservatively with whatever compound you choose.
7a methyl estradiol as opposed to 17a methyl estradiol with dbol/methyl testosterone
What are the differences as far as side effects between the two?
It appears that, according to almighty Wikipedia, the binding affinities are the same as estradiol:
Of course that doesn’t necessarily mean that they’re equipotent.
This paper states that the estrogenic activity was similar to estradiol:
“7α-Methyl-E2 resulted in potent estrogen activity via both ER subtypes with efficiency similar to natural E2.”
Edit: trestolone does not bind to SHBG, so it would not be surprising if its estrogen derivative does not either. This would change its bioavailability and metabolic clearance rate considerably:
Furthermore, from all of the anecdotal evidence I’ve read, it seems to raise prolactin quite a bit, and exacerbates gyno.
I don’t know about that. Could be that the 7a methyl group does prevent that, but the structure of the aromatic steroid is significantly different from its non aromatized counterpart. It would surprise me if it doesn’t bind to SHBG.
It seems MENT has estrogenic effects unrelated to 7a-Methylestradiol. Prolactin could be a factor.
Nice post
It’s certainly possible that it does. The aromatized version has an extra hydroxyl for hydrogen bonding to SHBG, and the aromatic ring for pi-stacking interactions.
According to this paper, an Asp residue hydrogen bonds with the C3-OH, and the C17-OH hydrogen bonds with a Ser residue. (This is backwards from the binding orientation of T, which involves hydrogen bonding of the C17-OH with the Asp residue.) Also, there’s a Trp residue which seems to provide pi-pi interactions with the aromatic ring of estradiol. Unfortunately, it’s just an abstract:
All of this is over my head lol. Where does the unit conversion chemistry stuff come in? I can handle that lol!
I see you talked about TBOL in one of the early replies. Have you considered using superdrol? I know it’s the worst oral out there healthwise, but if you want to keep your gains and not only keep, but increase your strength immensely at the end of your cut, SD will definitely do that for you while giving you that dry, hard look. I only mention this due to how harsh Tren is on the body. If you are looking at using Tren in the future, then SD is no worse for you with less side affects. Biggest downside is the hepatoxicity and many people say it makes them extremely lethargic. It’s practically the oral tren. I had no side affects from it during the four weeks I used it at 20mg ED with 125mg test a week. Strength also increased 15% on all my compound lifts.