Crashed E2 - Uh Oh

Pharma TRT
61

I appreciate your views and I appreciate your contribution. I do feel your taking a stance based on your experience which is relatively isolated. I’m sure you can find plenty of people who say it doesn’t matter which test. There are alot of people who disagree. Very reputable doctors in fact. One thing I havent seen you do is regardless of your test and comparisons acknowledge that lc/ms is consistent. Here is a quote from John Crisler MD from Michigan who disagrees with you whole heartedly based on his vast experience dealing with thousands and thousands of patients.
"The above statement, by LEF, demonstrates a fundamental lack of understanding of laboratory methodology. I don’t know who wrote it, but it could not be more wrong.

I stood at the kitchen counter at William Faloon’s house as couple months ago (my GF and I stayed there for the night), and showed him a laboratory printout (I could have brought many of them with me) proving my point about the standard Estradiol vs. Sensitive. The patient’s symptoms matched the Sensitive assay, not the standard assay.

Quest Diagnostics has proven my point as well, after I showed their Director my results, years ago. It’s right on their laboratory results, IF you make the mistake of ordering the standard E2 assay.

Simply, an invalid assay is an invalid assay. Arguing about the lower range for an invalid assay is like arguing about how much you should pay for something which is worthless.

Now, just using some farmer’s logic, just whom is the Sensitive assay to be used for, then?"

62

Good stuff.

The Pfizer researcher who operates IA and LC/MS equipment told me IA is easier to work with and LC/MS methodology is much more prone to operator error and not as consistent as IA.

I am aware of John Crisler and his work, my doctor knows him well.

If I know nothing else at this point, I know we all have unique experiences and results and though I do know a few others doing what I am, I admit it is a small sample. I believe most of us would do fine with the immunoassay. Certainly not all.

As for who should get the sensitive assay, the doctor with Quest told me someone with E2 levels so low (<15) that the IA would not pick it up. He believes Quest’s disclosure on the lab report is clear on that. Otherwise, it’s 50/50, he was “on the fence”. Always nice when experts disagree.