[quote]Bill Roberts wrote:
I think you have an excellent point on skin conversion of transdermally applied T to DHT being undoubtedly affected by the method of application. I was really referring to the general approach at the time being focused on (then) ever-nastier patches, trying for smaller and smaller size but more and more powerful penetration enhancement, rather than a specific substance.
I can’t say what was being thought in the industry with regard to testosterone.
I do know that in pharmaceutical science at the time, the focus in general was formulating for maximum delivery into smallest possible skin area even where skin metabolism was no issue; and I never once saw an effort towards allowing much larger area and much less transport per unit area (flux) on account of being less obtrusive after application. Maximizing flux was the Holy Grail and that was just that.
There are often weird things like that. For example, I am pretty sure you will find medicinal chemistry texts and most certainly medicinal chemistry professors and lecturers who will say that the principal thing, or I even once read, the DEFINITION of medicinal chemistry was increasing potency.
(Meaning, effect per milligram.)
Now that’s just flat stupid.
If derivative B requires three times the milligrams for same effect, but has less side effects at therapeutically-equivalent doses, a more suitable half-life, and is cheaper to manufacturer, then it’s better regardless that it is less potent.
Yet you could find literally thousands of articles in medicinal chemistry where potency is sought as the Holy Grail.
Sidetrack, but not unrelated.[/quote]
Excellent points.
I have a feeling Big Pharma was simply looking out for layman, everyday user convenience - I.E. the more potent, less amount of gel/cream applied, therefor will have a higher user acceptability ratio, therefore more sales.
I don’t think they were necessarily concerned about things pharmacological speaking, just looking to get a higher user rate.