CLA

Has anyone who has used CLA actually lost body fat in measurable amounts?
If so, at what daily dosage, over what period of time, were you on a normal or modified diet at the time, were you using any other weight-loss supplements or stimulants, and assuming the moderators allow it, what brand(s) did you find effective?

Like many T-Nation members, I’m familiar with much of the research in animals and humans that is often cited(I’ve actually read and digested the info in a few of the abstracts), and I’m hip to the data that suggest the trans-10, cis-12 isomer of CLA is responsible for the positive benefits regarding lipid profiles and body fat composition. But I’m curious as to the real world experiences of active, weight-trained individuals.

Yes at a gram a day… however your body fat must be pretty low already to “see” results. My own accounts, i have found that when I do not take CLA i can put on fat much faster. Also understand that CLA should be something taken for the rest of your life kind of thing, not a fast acting fat burner.

Diabetologia
Publisher: Springer-Verlag Heidelberg
ISSN: 0012-186X (Paper) 1432-0428
Issue: Volume 47, Number 6

Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity
Hyperproinsulinaemia reflects both beta cell dysfunction and insulin resistance in cross-sectional studies, but it is not known whether changes in proinsulin
concentrations are related to insulin resistance over time. As trans10cis12 (t10c12)-conjugated linoleic acid (CLA)supplementation induces insulin resistance in obese men, we used this fatty acid to investigate the effects on plasma proinsulin, insulin, C-peptide and adiponectin concentrations, including their associations with change in insulin sensitivity.
Methods We randomised (double-blind) 57 non-diabetic abdominally obese men to receive either 3.4 g t10c12CLA,
CLA-isomer mixture or control oil for 12 weeks. Insulin sensitivity (hyperinsulinaemic-euglycaemic clamp), intact proinsulin, insulin, the proinsulin : insulin ratio, C-peptide, glucose and adiponectin were assessed before and after supplementation.
Results Supplementation with t10c12CLA increased proinsulin (p<0.01), the proinsulin : insulin ratio (p<0.05) and
C-peptide concentrations (p<0.001) in comparison with control subjects. Adiponectin, however, did not change significantly. The change in proinsulin, but not the proinsulin : insulin ratio, was related to impaired insulin sensitivity (p<0.0001), independently of changes in insulin, C-peptide, glucose, adiponectin and BMI. Conversely, the correlation between insulin sensitivity and specific insulin (p<0.001) did not remain significant after adjustment for proinsulin. Induced hyperproinsulinaemia was also correlated to adiponectin concentrations (p<0.01).
Conclusions/interpretation: In obese men, t10c12CLA induces hyperproinsulinaemia that is related to impaired insulin sensitivity, independently of changes in insulin
concentrations. These results are of clinical interest, as hyperproinsulinaemia predicts diabetes and cardiovascular disease. The use of weight-loss supplements containing this
fatty acid is worrying.