First off, these threads are full of fantastic info so many thanks to all contributors. Im looking at running with
3 x 1000mg Piracetam
3 x 100mg DMAE
as my exam season is approaching and I could use a bit of a boost. Im also taking in a fair bit of caffeine daily. Does this seem OK or is there something major that is absolutely necessary (vinpocetine?). Also if anyone has any good UK sources I’d appreciate a PM.
Thanks
[quote]bushidobadboy wrote:
Modafinil and spike worked fabulously for me. I was a studying MACHINE for 2 youares lol. However I do NOT advise anyone to stay on modafinil for that long. I now have a sensitivity to the stuff and after about 15 months on modafinil 5days/wk or so, I had a very tender liver.
If I take moda these days I am irritable, gut-inflamed and looking and feeling pretty crap.
My suggestion would be to try some selegeline before the moda.
BBB[/quote]
What would the recommended dosage for Selegiline be for my purposes? I got my hands on some, but I’m coming across several recommendations, usually in between 1.5-5mg per day. I saw in another thread you were recommending 2.5mg EOD, but this was in relation to a PCT protocol.
Also, how about contraindications or drug interactions? It sounds like there are no dietary interactions at doses under 10mg, but that I should also take it easy with the stimulants. I only use caffeine at around 200mg, but it sounds like I should scale my dosage back.
Are there any other supplements/noops I should make sure not to combine with the Selegiline? Currently taking vinpo, DMAE, occasionally a low dose of galantamine (just trying to finish off an old bottle I had lying around), bacopa, and of course racetams. I sometimes use a melatonin/valerian supp before bed.
I appreciate the help! 
I’ve skimmed the last bunch of pages, but haven’t seen a recommendation, I don’t think… forvgive me if it’s a blatantly obvious answer I missed haha…
Anyway… What would be a good choice for a next step from vinpo/dmae/ani stack? I felt the aniracetams effects pretty strongly when I first started using it, but not so much any more. Maybe I just got used to it?
Either way, I was thinking about trying pira or prami… Thoughts?
(I’ve also used oxi a couple of times, pre studying. This stuff’s awesome. hah)
[quote]rrjc5488 wrote:
I’ve skimmed the last bunch of pages, but haven’t seen a recommendation, I don’t think… forvgive me if it’s a blatantly obvious answer I missed haha…
Anyway… What would be a good choice for a next step from vinpo/dmae/ani stack? I felt the aniracetams effects pretty strongly when I first started using it, but not so much any more. Maybe I just got used to it?
Either way, I was thinking about trying pira or prami… Thoughts?
(I’ve also used oxi a couple of times, pre studying. This stuff’s awesome. hah)[/quote]
According to wiki, piracetam would be a step down for you b/c I’ve heard it’s weaker than ani.
Pramiracetam would be a step up, b/c I’ve heard it’s stronger than ani.
I’m sure BBB will see this and be able to provide a better answer.
[quote]rrjc5488 wrote:
I felt the aniracetams effects pretty strongly when I first started using it, but not so much any more. Maybe I just got used to it?[/quote]
You got used to it. Happens with everything in life, racetams included.
Piracetam is used in way higher dosages than aniracetam, don’t think it will add much.
BBB, i was researching vinpocetine and found you wrote this in one of your old posts:-
“Vinpocetin also sounded interesting (powerful antioxidant and neuroprotective amongst other things). Unfortunately it often made me feel as though I was on the brink of a hypo all day (whether I had taken any exogenous insulin or not). Consequently I was unable to concentrate unless I was eating sugary foods… Not ideal, lol.”
I am getting the same sort of thing from vinpocetine now, although when I first tried it I had really great results, can you let me know what you did to prevent this?
I also looking like I’ve had a night out on the ale whenever I take it now, it’s strange that I had non of these side effects when i first took it.
Stacking Ani, Oxi (for intense study sessions only), DMAE, Vinpo, Choline Citrate
Ani: 600 mg x’s 3
Oxi: 800 mg whenever needed
DMAE: 600 mg x’s 3
Vinpo: 10 mg x’s 3
CC: 1 gram x’s 3
Feel pretty good with this stack. In tough classes and retaining a lot of info.
I just ordered Prami. Have never taken it. Dosage instructions? Should I take along with Ani? Both, I know, are fat soluble.
Also ordered Citicoline CDP-Choline and
Alpha-GPC.
I think I may replace DMAE with Citicoline CDP and use A-GPC before bed to boost GH and recover my choline from that nights study session and racetam use.
What you do you guys think the dosages should be with the Prami, CDP, A-GPC?
Who saw Limitless!? Cool movie if you are into the Noops!
[quote]duddy wrote:
Who saw Limitless!? Cool movie if you are into the Noops![/quote]
I did. Thought of this thread immediately.
BBB, what do you think about this;
They’re saying ditch Vinpo basically. Main arguments are:
“In other words, while vinpocetine may be neuroprotective under some experimental and clinical conditions, it may also interfere with monoamine storage, and affect the way in which the brain responds to drugs acting through dopaminergic, adrenergic, or serotonergic pathways (e.g. amphetamine, modafinil, methylphenidate, cocaine, SSRIs, bupropion, etc). Serious consideration should be given before taking vinpocetine, as it is a highly active pharmacological agent that interacts and interferes with a wide array of brain systems and functions.”
"Then I noticed through researching studies that vinpocetine has a negative impact on the NMDA receptors and the AMPA receptors. These are two very important receptor systems that substances claimed of being nootropics should elicit a positive affect on or no affect at all. "
My personal experience with it hasn’t been too bright either: it seems to put me in a ‘down’ mood.
Thanks for your input
Guys,
Does anyone have any comments on today’s article i.e. chocamine and nicotine as ‘nootropics’?
Oh yes, my first post
I started on Vinpo about a month ago, 3x10 ED. (built up)
Added DMAE a few weeks back, 2x500mg 5-6 days a week.
Started on Hup-A 50-100mg 5xweek but stopped taking it about a week ago due to updated recommendations.
I started on Ani last Thursday, 2x750mg ED. I’m not sure what the time to effect is with Ani?
Anyhow, I’m not sure if I’m noticing much of a difference. Granted, it’s only been a few weeks so I’m willing to give it some time. I might, might be a bit less ‘down’ than before starting on these. This a good thing.
I also tried DMAA (geramine) but discontinued after about a week. It did give me calm energy, but also made me somewhat content and had a negative effect on libido so I stopped.
I’m also taking vitamin D and Flameout. Sidenote, some years back I took anywhere from 10-25 tabs of fish oil (30% EPA&DHA) for a span of about 2 years and can’t really say that there was change in my mood, concentration or brain function in general.
I’ve been taking valerian root for the past 5 or so months but can’t say that it has had an effect since I started using the Vitamin Shoppe brand. The brand I was using before did help for relaxation somewhat.
Btw if anyone is in the NYC area and wants what’s left of my DMAA and Huperzine A, let me know.
I have been stacking:
Vinpo
Ani
DMAE
Bacopa
Using Oxi for longer study sessions, however Vinpo is not being sold at the moment are there any substitutes that can be taken daily.
Also any Noops you all have tried with better results? I like my stack but, I am always looking for better products/additions.
[quote]theceka wrote:
BBB, what do you think about this;
They’re saying ditch Vinpo basically. Main arguments are:
“In other words, while vinpocetine may be neuroprotective under some experimental and clinical conditions, it may also interfere with monoamine storage, and affect the way in which the brain responds to drugs acting through dopaminergic, adrenergic, or serotonergic pathways (e.g. amphetamine, modafinil, methylphenidate, cocaine, SSRIs, bupropion, etc). Serious consideration should be given before taking vinpocetine, as it is a highly active pharmacological agent that interacts and interferes with a wide array of brain systems and functions.”
"Then I noticed through researching studies that vinpocetine has a negative impact on the NMDA receptors and the AMPA receptors. These are two very important receptor systems that substances claimed of being nootropics should elicit a positive affect on or no affect at all. "
My personal experience with it hasn’t been too bright either: it seems to put me in a ‘down’ mood.
Thanks for your input[/quote]
Interesting. Absolutely interesting. But my experiences with vinpo, ani and dmae have been great, I definitely have better memory.
There’s a wrong way to use it, IMO. If I take it and don’t eat carbs, I become slightly hypoglycemic. And if I OD (60mg a day for two days, I do this just before exams) I get a headache afterwards.
And regarding the AMPA, NMDA and long term potentiation thingies: All things considered, my memory has improved. So if it does interfere with this, maybe it’s just one piece of the puzzle? And maybe it improves another piece we haven’t found? That was one study from rodent oocytes and one from striatal tissue. Does it hold true for the human hippocampus as well?
Anyway, thanks for posting, it’d be interesting to hear BBBs thoughts on the matter as well.
I think I’ve run across some problems taking too much aniracetam for my DMAE intake, when my DMAE gets here I’ll do some more experiments to confirm it before I write a little horror story here.
Just the thoughts of a layman, probably pointing out the obvious.
Vinpo increases cerebral bloodflow.
Brain uses energy.
More blood to brain equals more energy being used.
More energy being used requires a higher energy intake to prevent hypoglycemia.
Pretty simple, no?
I’ve also got some centrophenoxine on the way. I’ll keep some notes or a log about the effects for anyone interested.
It was also monkeys for one of the studies done.
[quote]If vinpocetine does indeed act in a “reserpine-like” fashion in striatal dopaminergic neurons, one could legitimately raise concern over the use of vinpocetine in otherwise healthy individuals for “cognitive enhancement,” as side effects may manifest consistent with reserpine-like side effects, including depression and cognitive dysfunction.(7,8)
…
7. Huffman JC, Stern TA. “Neuropsychiatric consequences of cardiovascular medications.” Dialogues in Clinical Neuroscience 2007;9(1):29-45. PMID: 17506224.
8. Cai JX, Ma YY, Xu L, Hu XT. “Reserpine impairs spatial working memory performance in monkeys: reversal by the alpha 2-adrenergic agonist clonidine.” Brain Research 1993 Jun 18;614(1-2):191-6.[/quote]
From
Would a diet like the Pulse/leangains/intermittent fasting lessen the effects of vinpo, ani, DMAE?
Given that they should be taken with food (carbs,fat) and the diet strategy basically calls for fasting or only drinking protein until the last 6 or so hours of the day?
So I should take vinpocetine with some sort of sugary sports drink?
I always took it with food anyway, breakfast, lunch, dinner, so thought that I would be getting enough carbs from this, but maybe something more fast acting?