Bloodwork 14 Weeks into TRT, Very High T and E

Lab results 14 weeks or so into treatment.

200 mg / week since day one.

I have low SHBG (10), so by the third week I opted to change my protocol from the doctor’s recommendation of 200mg once a week to EOD injections. Energy is stable, libido is going strong, lifts are going up, body recomp is well under way. My mental clarity and drive is also at an all-high. Life is good again.

Now, I know the E looks high, but do you guys think that it’s high relative to my Total and Free or does it look to be in line? I feel pretty good, though occasionally I get a little bit of nipple sensitivity. Never anything alarming of overly painful, though.

I also notice a little bit of water retention, though that has decreased significantly as the weeks have gone on.

Let me know your thoughts and opinions.

Your Free T is above range and you can’t expect E2 not to be as well. The only thing that matters is you are symptom free and functioning normally.

I find on occasion the sensitive test reads higher than the standard test.

I have to respectfully disagree with @systemlord on this.

With those test dosages and lab numbers you’re more likely to have issues down the line. I’m sure you fell great now as you’ve been on a mini cycle for 14 weeks.

High e2 tends to encourage thick blood therefore higher blood pressure. BPH is also linked to e2.

Glad you feel great now but there is a bigger picture to consider as you run TRT over time.

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I’ve updated my OP with the other markers my PCP had tested. Obviously, this is my first draw since starting TRT, so it will serve me as a sort of baseline to compare to down the line, but I will keep your input in mind.

As I said, so far, I feel great. If that changes, I am comforted knowing that I respond well to treatment and have some room to back off the dose a bit, which should help mitigate any issues that might arise.

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What evidence do you have for this? Issues?

@TestQuest22 ,

Great free T #s on that dose.

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Is this the part where I offer you some googled medical papers and then you discredit them and then I defend them for a while and then you produce your own papers and then I discredit them and so on and so forth🙂?

More testosterone-> more red blood cell production → more hypertension & higher pulse pressure

More e2 → more water retention → more hypertension

More e2 → more effect on prostate target tissue → more BPH

Google away if you’re interested but I suspect this angle challenges your current narrative so I doubt you’ll be very receptive.

Likewise feel free to provide evidence that there is no relationship between high e2 and prostate growth and also that there is no relationship between e2/water retention/hypertension or test and red cell count I’m happy to consider them against my current view.

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So, no evidence for your claim. Got it!

Merry Christmas maybe you’ll get some Arimidex in your stocking​:joy:. Ho ho ho :santa::snowflake:

Nope. I already have a full bottle that I never used. My joints are thanking me every day.

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Disclaimer - I do not condone the unnecessary or over use of Adex. Neither do I generally support doses of test that require Adex for e2 management.

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This is the kind of response I’d expect from someone with low SHBG compensating by injecting more often. You have some room to lower your dose a bit if you’re concerned, but if all other health markers are fine (BP, PSA, lipids, CBC, etc) then I’d keep it up

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TRT (T) can cause sodium reabsorption via the kidneys, so it’s not always E2 causing the water retention.

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