Beta-Adrenergic Desensitization and Bodyweight

How would beta-adrenergic desensitization reflect on your scale weight?

I noticed that in the short term it often happens with a weight drop. But it’s not the desensitization that causes it, rather the excess of cortisol and adrenaline that leads to the desensitization cause also cause weight loss,mostly from muscle glycogen stores.

If it is sustained over the longer term, it should make it harder to lose fat because of a lower body fat mobilization (for fuel) and thus weight is more likely to increase. At the same time it is likely going to cause lower muscle glycogen stores because the body would rely more on glycogen for fuel due to the less efficient fat mobilization. So it would make you look fatter and flatter (smaller, softer looking muscles).

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That’s makes perfect sense. I notice that heading into a deload week, my weight usually drops by a couple of pounds but then jumps back up by the end of the week. Thanks!

Coach, one more thing I’m curious about:

Does cortisol raise nor-adrenaline, which in turn raises adrenaline or does nor-adrenaline assess whether a situation is a serious threat or not first, and then set off the cascade of cortisol (to mobilize energy) and adrenaline?

Saw this one in CT’s OCTS introduction course. The second one is more correct.

It’s the amygdala (also called ‘the reptile brain’) located in the hypothalamus that triggers the release of cortisol and adrenaline via the HPA axis. Whether or not your amygdala gets triggered is almost entirely up to your subconscious beliefs, fears and convictions.

If your subconsciousness perceives a situation and/or person like a threat, the amygdala gets stimulated via sensory (sight, touch, hearing etc.) input and the hypothalamus signals the pituitary gland to release adrenocorticotropic hormone. When this hormone reaches the adrenals, they in turn start producing cortisol first, then adrenaline. When cortisol gets released it increases the activity of the enzyme that’s responsible for the conversion of noradrenaline into adrenaline.

The moment before your subconsciousness decides whether something or someone is a threat is the moment when noradrenaline gets released. This is mainly to increase focus/concentration in order for you to be able to assess the possible threat. So yes, noradrenaline gets released slightly before cortisol and adrenaline but it all happens really fast.

Second one. Nor-adrenaline is raised first when there is a potential danger. t increases focus and perception. If the situation is deemed a real danger, cortisol is released and, among other things, it converts noradrenaline to adrenaline.

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Crystal clear. Thank you.

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