Oxandrolone has a half life of roughly ten hours in otherwise healthy men and women.
Given the high doses people tend to take nowadays (at least 20mg/day, with many pushing 50-100mg/day which I think is insane) just taking it once per day should be good enough, 24 hours later you are going to have around a 80% fluctuation in blood concentration of oxandrolone
so if you are taking 50mg/day, the nadir is still going to be more than high enough to facilitate anabolism
If you were taking something with a REALLY short half life like dbol (3-5 hours) I can understand dosing multiple times per day but even then I think people are just nit-picking at that point
I understand bodybuilders tend to be very focused on small intricate details like counting calories, tracking macros etc and every tiny edge you can eek out to get an advantage over your fellow competitors matters
But ultimately if I’m taking dbol (I’m not, but have tried it briefly at between 5-20mg/day and I don’t understand why anyone would feel the need to take more than 20 if they aren’t a competitive bodybuilder) am I really going to notice better gainz over four weeks because I’m taking it 2-3x daily vs just taking it in the morning before I go to gym?
I doubt it… Dbol is generally considered a harsh drug and you can only sustain “safe” (I use safe in quotations because any amount of dbol is going to skew lipids quite significantly and you often wind up with increased BP, increased RHR etc on something like dbol)
Are you really going to eek out an extra pound of muscle tissue over four weeks by dosing dbol 2-3x per day vs 1x per day?
With anavar maybe you can use it a little longer (8 weeks etc) but even then… you’re taking the hormone, it’s in your system the next day at the time of dosing again… Even if it’s only in your system for most of the day (like dbol) that duration of time is enough to facilitate enough of a pharmacological benefit
And one could also argue you’d have a much higher cmax with once per day dosing… is that peak concentration more important than steady state considering we are dosing every day regardless??
The only rationale I can see behind the multiple times per day dosing is perhaps more steady influx of the hormone decreases the degree to which you’d wind up with estrogenic or androgenic side effects… with anavar this isn’t really relevant unless you are exceptionally sensitive you you’re one of those people pushing like 100mg/day or something insane like that.