Other reason for high prolactin
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High Estradiol. It is no secret that, if you increase estradiol, you will increase prolactin release. [2] Some of the older research showed that this effect was dose dependent, i.e. the more estradiol you added, the higher prolactin increased. [3] And researchers have discovered one of the key mechanisms: estradiol regulates the transcription of the prolactin gene . [4] So, if you are on the high side with prolactin, one of the first things you should probably pull is estradiol. Remember that, as men, we need the appropriate LC-MS/MS test that can pick up our relatively low levels of estradiol (compared to a female).
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Hypothyroidism. An underactive thyroid will also drive up prolactin levels in us men. Of course, this is an especially ugly situation, because hypothyroidism tends to lower testosterone and sap your energy levels. So, if you have hypothyroidism and high prolactin, you have potentially got a nasty set of symptoms to manage. Furthermore, hypothyroidism is underdiagosed, because so few doctors really test adequately for low thyroid function.
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Drugs. Many very common classes of drugs can raise prolactin levels. No, they didn’t put that on the label, did they? Look at this list from one set of researchers: " antidepressant drugs with serotoninergic activity, including selective serotonin reuptake inhibitors (SSRI) , monoamine oxidase inhibitors (MAO-I) and some tricyclics, can cause hyperprolactinemia. A long list of other compounds may determine an increase in prolactin levels, including prokinetics, opiates, estrogens, anti-androgens, anti-hypertensive drugs, H2-receptor antagonists, anti-convulsants and cholinomimetics." [6]