Beating Down SHBG - 1st Bloodwork Interpretation Post-TRT

[readalot]

Great summary. Some newer thinking on the TT/fT thing with respect to HPTA control/feedback loop:

Naturally High Test & Estradiol, Still Feel Awful

Thanks for clarifying the ranges and units. Good job getting decent fT test through Quest (equiibrium dialysis). More mythology IMO. Intelligent opinion and clinical data indicate HPTA controls free testosterone (fT) not total testosterone (TT) and SHBG+fT yields TT. Hence, if you waved a magic wand and lowered your SHBG your fT would stay the same and TT would drop. I tried this on myself by using medication (oxandrolone) that lowers SHBG. Some additional comments about this: @FunkOd…

If you look there is some good evidence that HPTA controls fT not TT. Hence if true, trying to lower SHBG is pointless. If on TRT, pointless as well. Body eliminates fT not TT.