I tried looking this up and ended teasing countless threads about people adex doses and if
5 mg is enough.
now my question id why do we dose arimidex eod. or e3d? would it make sense to jusy take .25mg ED throughout my cycle? I cant think of aany reason but is there a reason I shouldnt do this?
is it just for convenience that the norm is EOD?
[quote]Lift-up-put-down wrote:
I tried looking this up and ended teasing countless threads about people adex doses and if
5 mg is enough.
now my question id why do we dose arimidex eod. or e3d? would it make sense to jusy take .25mg ED throughout my cycle? I cant think of aany reason but is there a reason I shouldnt do this?
is it just for convenience that the norm is EOD? [/quote]
I would assume the EOD dosing schedule could be put down to the 46.8h half-life.
I think the primary reason why taking .5mg EOD rather than .25mg EOD has become somewhat standard practice is that splitting 1mg pills in fractions smaller than 1/2 is just a pain in the ass. Given the half-live of Anastrozol (40-50 hours, as said above), EOD dosing is an effective and convenient way to take the drug, which is not to say ED dosing wouldn’t yield slightly more stable plasma concentrations of the drug if one is able to do it, either by buying liquid Adex or by dissolving the pills in high proof liquor. Whether there will be an added benefit to this (somewhat marginal) difference, I don’t know. Probably not.
The discussion about the total weekly dosage needed is an open one, I think. Here are my thoughts on it:
The standard practice is to take more or less .5mg EOD which totals 3.5mg/week. This recommendation is somewhat independent of total aromatizable drug dose, which seems contradictory to the general consensus that more anti-aromatase action is needed as aromatizable drug dosage rises and the general observation that estrogen related side effects worsen as the dose goes up, even when an AI is being used and the dose (the AI’s dose) remains constant.
The 3.5/week standard seems to be enough to prevent gyno in the range of Testosterone usage that is normally seen among recreational AAS users but in some cases seems insufficient to prevent other, less dramatic, side effects such as acne and water retention. Most people who cycle steroids don’t measure their estrogen levels during cycle which makes it more difficult to determine if the AI dose they are taking is enough to keep their levels within range.
Some TRT guys have tried to come up with a formula to adjust Adex dose to Testosterone dose. The basic recommendation is to take 1mg/week for every 100mg of Testosterone and adjust from there shooting for an estrogen range between 20 and 30 pg/ml, keeping in mind that there are some users (not a few, judging by the number I’ve encountered on these boards) who are very sensitive to the drug and who need to take much less than their less sensitive peers.
According to this formula, a person doing a basic cycle of Testosterone at 500mg/week would take 5mg/week of Arimidex, or approximately .7mg/day. This seems excessive by today’s standard but I think it would be interesting to find out, by measuring levels during cycle, if this is the case or if this practice can indeed field more desirable levels of estrogen that minimize side effects.
I have been on trt for a little over a year now. 240mg a week, taken bi weekly. My problem is that my body is extremely sensitive to estrogen, if I get in the mid 40’s I lose erection and have to take cialis, if go to low I lose erection and cialis won’t even work! My last labs were two weeks ago my T was 1396 and estrogen was 42, I gave blood to get red blood cells back in check and three days later the ed started so I upped my dosage if arimidex to 1/2 EOD for two days then went back to the 1/4 dosage and blew right past the sweet spot to the bottom side! It is tricky to say the least to control. I am wondering if I should lower the dosage of test. Any advise??
[quote]Saltlife717 wrote:
I have been on trt for a little over a year now. 240mg a week, taken bi weekly. My problem is that my body is extremely sensitive to estrogen, if I get in the mid 40’s I lose erection and have to take cialis, if go to low I lose erection and cialis won’t even work! My last labs were two weeks ago my T was 1396 and estrogen was 42, I gave blood to get red blood cells back in check and three days later the ed started so I upped my dosage if arimidex to 1/2 EOD for two days then went back to the 1/4 dosage and blew right past the sweet spot to the bottom side! It is tricky to say the least to control. I am wondering if I should lower the dosage of test. Any advise??[/quote]
You may want to go start your own thread in the TRT section.
thanks for the insight guys, this wad all very helpful and great input.