Hey All, new to the forum and was hoping to get a little feedback as I’m not an expert on TRT by any means. I have been on the therapy for 3 months. The first two months I was on 100mg weekly but when they tested my levels at the mid-point I was still pretty low. They then increase to 150mg weekly at that is what I’ve been on for past 5 weeks. My levels at the mid-point was then 809 ng/dl with 692 ng/dl bioavailable.
However, my Estradiol spiked as you can see from the numbers below and they put me on anastrozole 1 MG tablet taken on Monday, Wednesday and Friday. I’ve been on it for two weeks or so and I don’t feel well at all. Depressed, lower energy, upset stomach and my joints are hurting especially in my fingers and wrists. First, can anastrozole have these sort of side effects and secondly any recommendations I should make to my Urologist? I felt much better without the anastrozole even though my estrogen was above normal. Appreciate the feedback!
Well, no. Thats the problem with people using words like “amazing” for some small stupid shit that doesnt matter. We cant speak, or understand anything anymore.
Your e2 had a normal raise by some 20% which is normal side effect of pinning testosterone. A “spike” would be if it has shot up to 100+. And even then - so what.
If u dont have any side effects of this increase, drop the Anastrozole. You actually answered your own question saying that ever since you started it, you feel worse, so… there is your answer already - then stop taking it.
What he said. In general, E2 increase is NORMAL with increasing testosterone levels. If you dont have any sides, you dont need anastrozole, etc. Use these very powerful (and side effect riddled) drugs on as “as needed” basis IMO
In general, what causes issue with E2 is the RATIO of E2/T. This is typically not a problem in TRT situations, as our bodies are amazing and invrease E2 as needed with increases in T.
Typically, the ratio gets out of whack when we cycle with very high levels of T and even then E2 is mostly a challenge when our E2 starts to come down (ending/post cycle) and the E2/T ratio gets stressed.
Any doctor that is up to speed on HRT would know you don’t treat slightly elevated E2 in the presence of elevated T unless you are symptomatic.
This should be malpractice. That is enough to drive your E2 to undetectable levels. Sounds like that happened and if you retested to confirm you would see that. The symptoms of low E2 are the same ones you are experiencing. Tell your doc immediately and inform him of your research.
Tell him that you feel fine with higher E2 and you don’t need a treatment. Tell him those dose of arimdex prescribed is far too strong anyway and you are having symptoms of low E2. Go test it if you must to confirm for the doc.