Only opiate/opioid painkillers to my knowledge, which an addict really shouldn’t be taking unless they’re in hospital and/or a chronic pain patient.
How so? The likelihood of SAE is very low. I’m in agreement… when you’ve tapered off and you’re clean you don’t need to be on naloxone.
However an addict should probably always have narcan on hand… if they relapse and feel as if they’re slipping out, this will save them if they realise they’re about to OD before nodding out.
But why not? Aside from blocking the effect of opiates they don’t interact with other meds (to my knowledge). Oral naloxone as seen in buprenorphine/naloxone or oxycodone/naloxone is hardly active, it ONLY exists to deter people from crushing and injecting the meds as it will bypass first pass metabolism and thus not be prone to hepatic breakdown.
Oral naloxone > First pass effect > 3% bioavailability… if that. It’s not dangerous and there are no interactions associated with the tiny smidgen of naloxone present in these formulations
If I recall correctly one would have to take EIGHT 10mg oxycodone/naloxone tablets Orally before the drug becomes active.
There are people who do this… there are people who take far more than this, but still… 80mg oxycodone = 120mg morphine… that’s a hefty dose, enough to kill someone without a tolerance who doesn’t use these meds.