anyone familiar with Stablon?
http://www.antiaging-systems.com/enews/stablon.htm
If so, what are your thoughts/opinions. Is it some gimmick or possibly a worthwhile product for those suffering depression?
It looks to me like an interesting idea worth trying.
I have never believed that the in-practice effect of SSRI’s (the opposite, so to speak, of what this is) is achieved via the claimed mechanism.
Serotonin re-uptake inhibition is an effect occurring basically immediately upon sufficient levels reaching the bloodstream.
But anyone knowledgeable about it can tell you that SSRI’s cannot be expected in practice to work immediately: no, it takes many days before any beneficial effect will be seen.
And for that matter, beneficial effect can take a couple of weeks to wear off. Whereas the reuptake inhibition becomes negligible and stops as the drug levels drop fairly low and then to zero. That happens much faster than does loss of benefit.
That just doesn’t fit in with the claimed mechanism at all.
Anyway, SSRI’s aren’t all they’re cracked up to be, though in many cases they do provide some help and so if they work for an individual, great, but they surely are not tbe be-all and end-all for everyone.
This new drug sounds promising and has a legit a claim to possibly being effective as anything else.
That said, personally I would try (and have tried and in practice do) combining the methyl donors S-adenosylmethionine (SAMe), for example 400 mg in the morning, and trimethylglycine (TMG), for example 1000 mg three times per day. (I don’t know that there is improvement from dividing the dose to 3x/day; it is simply what I do.)
Methylation is a necessary step in the natural production of serotonin and methyl donors may very well be in too short supply without supplementation. Both these supplements are known as effective anti-depressants.
Personally I not only was able to discontinue Lexapro (escitalopram) after adopting these supplements, and to better and I would say absolutely complete effect; but I have also been getting much better sleep than has been the case in years, including better than when I was taking Ambien, which I no longer need to take.
Serotonin is also involved in sleep.
But that is not to knock this new drug: it is simply suggesting a nutritional alternative that may address the actual problem directly. (And in fact does in cases where the methylation step is the rate-limiting factor.)
It look interesting… but it aso look like they’re selling fake prozac and paxil. and that cant be a good sign!
http://www.antiaging-systems.com/a2z/paxil.htm
it also looks like the Stabalon is fake too…or a supplment trying to rip off a pharmeceutical name
http://www.servier.com/Pro/Neurosciences/Stablon/Stablon.aspx?id_=624
I know nothing about any particular website purveying it or something they claim to be it. I was referring to the actual drug being spoken of, tianeptine, which is a real drug and is indeed genuinely reported in the literature as having the claimed properties.
And Stablon is a real brand name of tianeptine, not a made-up one.
Again, as to whether that particular site is selling the compound they say they do or is selling a fake, I have no way to say and wasn’t commenting on. Dunno.
Search for Tianeptine/Stabalon on mindandmuscle.net
A lot of the guys there have used it. It definitely has a good rep.
[quote]Bill Roberts wrote:
I know nothing about any particular website purveying it or something they claim to be it. I was referring to the actual drug being spoken of, tianeptine, which is a real drug and is indeed genuinely reported in the literature as having the claimed properties.
And Stablon is a real brand name of tianeptine, not a made-up one.
Again, as to whether that particular site is selling the compound they say they do or is selling a fake, I have no way to say and wasn’t commenting on. Dunno.[/quote]
thats what I was getting at. it looks like the Stablon that theyre selling is counterfet.so does the paxil and prozac.
Out of curiousity, why do you say that?
Thanks for your insight Bill. I am not familiar with SAMe or TMG. are these over the counter? Where do you purchase them? What are your thoughts on using the protocol u suggested a long with the stablon? Overkill?
[quote]Bill Roberts wrote:
That said, personally I would try (and have tried and in practice do) combining the methyl donors S-adenosylmethionine (SAMe), for example 400 mg in the morning, and trimethylglycine (TMG), for example 1000 mg three times per day. (I don’t know that there is improvement from dividing the dose to 3x/day; it is simply what I do.)
Methylation is a necessary step in the natural production of serotonin and methyl donors may very well be in too short supply without supplementation. Both these supplements are known as effective anti-depressants.
[/quote]
[quote]Gambles wrote:
It look interesting… but it aso look like they’re selling fake prozac and paxil. and that cant be a good sign!
http://www.antiaging-systems.com/a2z/paxil.htm
it also looks like the Stabalon is fake too…or a supplment trying to rip off a pharmeceutical name
http://www.servier.com/Pro/Neurosciences/Stablon/Stablon.aspx?id_=624 [/quote]
This is nonsense. I’ve ordered from that site many times and the products they sell are legit.
Stablon is the trade name of Tianeptine, not a rip off. You seem very confused.
[quote]k8thegr8 wrote:
Thanks for your insight Bill. I am not familiar with SAMe or TMG. are these over the counter? Where do you purchase them? What are your thoughts on using the protocol u suggested a long with the stablon? Overkill?
[/quote]
SAMe and TMG are available at pretty much any decent supplement store. For example Vitamin Shoppe has them at good prices and so far as I know good quality and that’s the brand I use for those, but there are many sources.
Combining the supplement and drug approach might not, for a given individual, be overkill: after all, if there’s a problem with serotonin production due to limited methyl donation, then “simply” having this uptake enhancer may not be as good as correcting the serotonin production problem and also having the uptake enhancer.
But on the other hand, if the problem truly is fixed simply by addressing the serotonin production problem, why use the reuptake enhancer? That might well be overkill.
So I would give the supplements a fair chance before assuming the drug ought to be added in.
[quote]Bill Roberts wrote:
k8thegr8 wrote:
Thanks for your insight Bill. I am not familiar with SAMe or TMG. are these over the counter? Where do you purchase them? What are your thoughts on using the protocol u suggested a long with the stablon? Overkill?
SAMe and TMG are available at pretty much any decent supplement store. For example Vitamin Shoppe has them at good prices and so far as I know good quality and that’s the brand I use for those, but there are many sources.
Combining the supplement and drug approach might not, for a given individual, be overkill: after all, if there’s a problem with serotonin production due to limited methyl donation, then “simply” having this uptake enhancer may not be as good as correcting the serotonin production problem and also having the uptake enhancer.
But on the other hand, if the problem truly is fixed simply by addressing the serotonin production problem, why use the reuptake enhancer? That might well be overkill.
So I would give the supplements a fair chance before assuming the drug ought to be added in.
[/quote]
Makes sense. thanks Bill. If I give the supplements a try, how long should I give them a shot before deciding whether or not they are working? Would I notice a diff. immediately?
Smoke weed. You will notice the difference immediately.
1 Like
[quote]k8thegr8 wrote:
Makes sense. thanks Bill. If I give the supplements a try, how long should I give them a shot before deciding whether or not they are working? Would I notice a diff. immediately?[/quote]
Studies have shown some benefit from SAMe occurring within the first week, and benefit occurring for most that take it within 2 weeks. So 2 weeks seems sufficient for trial.
I would think the same for TMG.
[quote]bdog527 wrote:
Gambles wrote:
It look interesting… but it aso look like they’re selling fake prozac and paxil. and that cant be a good sign!
http://www.antiaging-systems.com/a2z/paxil.htm
it also looks like the Stabalon is fake too…or a supplment trying to rip off a pharmeceutical name
http://www.servier.com/Pro/Neurosciences/Stablon/Stablon.aspx?id_=624
This is nonsense. I’ve ordered from that site many times and the products they sell are legit.
Stablon is the trade name of Tianeptine, not a rip off. You seem very confused.
[/quote]
sorry about by kinda nonsense post , what I was trying to say is it looks like theyre selling counterfets or supplments under the names of real drugs.
but are they really selling real Prozac (Fluoxetine hydrochloride) , paxil(Paroxetine) , and Stablon(Tianeptine), you think?!
Another possible cause – and the causes could be occurring at the same time – for low serotonin could be low 5-hydroxytryptophan.
Though for example I personally don’t need the 5-HT, it wouldn’t be justified to assume that you don’t.
An appropriate dosage is 100-200 mg 2x/day inbetween meals.
The B vitamins, particular folate, B12 and B6, should be kept up also.
Thanks for all of your input Bill.
Sure thing!
I hope it helps! (The chances are quite good.)
Hate to be Cpt. Obvious here, but there is a ton of discussion on serotonin in this thread, but no one has asked what this woman’s diet is.
Is the OP on a low carb diet? An extremely low cal diet?
[quote]ovalpline wrote:
Hate to be Cpt. Obvious here, but there is a ton of discussion on serotonin in this thread, but no one has asked what this woman’s diet is.
Is the OP on a low carb diet? An extremely low cal diet?[/quote]
Oh no, definitely not a low carb or low cal diet. I’ve actually gained over 30 pounds the last year! That’s a lot for a little girl, lol, but it was much needed. I’m a former elite distance runner who definitely got a little caught up in training for the marathon (hoping to qualify for the trials) running over 100 MPW and not fueling enough… dropped down to 74 frickin pounds.
Long story short, got injured, stopped running, found lifting, and since have put on 30 + pounds, still hoping for another 15-20. Extreme bulking!!! lol I eat between 2700-3000 cals a day which is quite a lot for a little girl under 110 pounds right now but I’ve learned you gotta eat to grow and keep it clean.
I love the strength gains in the gym as my weight increases and after graduating (I’m majoring in psychology and exercise and wellness) I want to do something in this field… working with people, helping them discover the amazing results of exercise and good nutrition.
As far as my depression goes, I actually think it is a byproduct of my anxiety. I am an extreme perfectionist which is both good and bad at times, but it causes me to constantly worry and be down on myself. I’ve gotten better, but it is something I am going to be dealing with my whole life.
Done the traditional paxil/prozac meds but they didn’t help me at all and actually caused me to lose weight which is something I don’t want. So I am always interested in natural ways to reduce anxiety/depression.
Bill’s information was great, and I’m looking forward to starting his protocol; I also ordered the Stablon to have on hand if needed.
When feeling depressed…SMILE 
Makes its hard to feel depressed…try it