Great studies. You are going to send me down a rabbit hole. I have taken AIs in the past and now I worry about endothelial damage. Do you have any insight on whether any damage done from AIs is repairable?
It’s the AI
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No its not. Its the low e2 caused by the ai.
You’re allowed to be incorrect
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You are 100% incorrect.
And i think Gossamer knows this. Hes just trying to make a point to Dbossa
For those using an AI. I thought that too at one time. I’m not going to change your mind today but at some point in the future you’ll come to realize that you are wrong. Everyone has their own path but most come to the same conclusion eventually. I’m thankful it only took me a year. I thought I felt as good as it could get at points but I didn’t realize things could get better. Hopefully you get to experience that as well. Completely rethinking what you believe is true is not an easy task and usually requires hitting rock bottom first.
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Ais themselfs do not directly effect lipid or endothelial they indirectly do by the lowering of estrogen. So its not the ai itself its the effects from blocking the aromatase enzyme.
Since September
This is very true. The leaner I got the better I responded to TRT. Night and day.
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I’ve got at least 30 studies and other medical literature that directly contradict what this idiot is saying.
I just posted four that show harm to the endothelial and lipids. That’s not the only thing it harms.
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I’m beginning to think this gsx guy is a troll. He says the exact opposite everyone else says with zero evidence on a rather consistent basis. Makes assumptions out of thin air. Provides protocol suggestions that follow zero logic.
I say troll.
I’ve been saying that since like his second post
Here’s the total test, free test, and estradiol from my last 3 bloodworks. Not sure if the estradiol is sensitive or not. And if I remember correctly, the bloodwork was drawn @60 hours post injection. All 3 were from Quest labs:
Estradiol <20
Test 1045
Free test calc-ARUP 331
————-
Estradiol 62
Test 856
Free test calc-ARUP 308
—————
Estradiol 22
Test 859
Free test calc-ARUP 289
Where did you feel your best out of these 3?
@dbossa in your opinion, what prevents rock hard erections while on TRT? Before TRT I was in a very bad place. Total T was 200 and I had no libido and bad ED. Now my T levels are 800-1000 and my estradiol (pre-treatment was 16) is now 57. Before reading this thread I was considering starting an AI but now I think you guys have convinced me out of it after reading all 96 messages. I don’t feel a single symptom of high estrogen. I don’t have highs or lows. I inject twice a week, subcutaneously, 56mg each injection. SHBG is 8, free T is 32. Libido has slightly increased, I now have night/morning erections…but when it’s time for duty, I’m still having issues and it’s definitely not rock hard. Any idea what is preventing this? If I could solve this, I’d be very happy with the way things are going. Dr. Crisler said once that 40mg twice a week subcutaneous injections is about the same as 50mg twice a week IM injections. I wonder if I should decrease my 56mg dose.
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The first one. I was taking closer to 200 mg per week for a while before that bloodwork, as opposed to 160mg for the other 2. Not a huge difference, but noticeable.
It may very well be the AI, but from what I just read in those studies, it looks more like the high doses for breast cancer, such as 7mg anastrozole per week, is what they’re talking about. I may have missed it, but I didn’t see anything that had anything to do with .5 mg per week.
I’m going to share a personal experience here, which others have reported to me as well, but by no means is a 100% fix.
When my free T is 28 everything works quite well and I have no complaints. Erections are how I expect them to be. Lately I’ve been trying a higher dose and the number one significant change for me are the erections a like ‘viagra overdose’ rock hard. It’s crazy. My wife insists it’s even bigger than before (which is really just the increased blood flow).
Question is, have you ever tried to go ever higher just to see what the outcome was?
At a larger dose, the damage will happen quicker and will be easier to measure. At a smaller dose, the damage will still occur though it will take longer. In either case, there is harm. I’d rather have no harm and keep the benefits of estrogen.