What about this optimization stuff?
“The road to excess leads to the palace of wisdom … for we never know what is enough until we know what is more than enough.” William Blake (1757–1827)
HW for this week. Recast the axes on either graph to display the positive and negative impacts of TT/fT vs serum level. Make the x axis serum TT/fT level. Y axis is cost with one function being performance and the other being health impact. Do the curves necessarily have to be monotonically increasing or decreasing?
Why would the human body have evolved to operate between roughly 300 and 1200 ng/dl TT?
When you have finished what does optimization entail? Is the optimum always out on the far right of the graph? What are some tradeoffs that one needs to consider?
Why is a plot of TT/most hormones vs morbidity u shaped and why would each individual need to be careful when they deviate outside physiologic conditions [LOW or HIGH] especially on a long term therapy like TRT?
Sounds familiar…
https://www.nature.com/articles/hr2012165
