Wife started TRT through Defy. She was prescribed 50mg/ml Cypionate and instructed to inject .1 ml twice per week for 10mg per week.
After her first injection she felt symptoms she was unsure of, she reached out to Defy and they told her to keep going she shouldn’t feel anything for 3-4 weeks although she told them she was experiencing these symptoms. She is now on injection 3, and has experienced unpleasant symptoms for just over one week.
Anxiety
Random Panic Attack
Racing Heart
Tense
We’ve been told to drop her weekly amount from 10 mg to 5 mg for a few weeks so her body could get used to it, and then raise it back to 10 mg.
Any ideas what may be causing this? What should be done to fix?
Hormone therapy can be tricky for some, especially if nutrition is poor, vitamin or mineral deficiencies, excessive dosing, hypothyroidism and other untreated medical problems can make TRT a little more challenging .
Your wife could simply have a very high sensitivity to androgens.
Right now I feel like I’m throwing darts at a dart board in the dark.
I think it’s best to start from the beginning, what were your wife’s pre-TRT lab work up?
10mg is a high dose for women to start on, IMO. 5-8mg seems the normal range. Maybe she does need 10mg, but I still wouldn’t have starter her there. My wife is also prescribed Test C 50mg/ through Defy but we started her on 5mg/wk (.05ml 2x per week). It has been amazing for her energy, mental focus etc but she was very low T to begin with. We have not done follow up labs to see where her levels are but will in the next 30 days I believe.
I’m amazed how differently ppl respond to hormones. We’re all different, but sometimes it takes this reaction to know that she needs to start low and slowly work up. Good luck
Regarding the dose being too high, we thought the same, lowered her dosage to 5mg per week, .05 per injection. She has only taken one injection at .05. Still too early to tell if it has helped. We were even thinking of dropping her to 3mg per week if needed.
It’s always best to post all labs, this way members can critic them and offer other possible causes for symptoms.
Ferritin (iron status) should be a lab you would want prior to and after starting hormone therapy.
I had low iron at the start of TRT and had all the symptoms your wife is experiencing. TRT absolutely wrecks me if I have low ferritin, low iron. It was so bad I had to stop TRT for 8 months to figure it all out.
According to the Boston University School of Medicine, anything under 25 ng/dL for a women under 50 is low.
Also, according to the Boston University, a Free T (direct radioimmunoassay), women under the age of 50, a level of <1.5 pg/mL is considered low.
Low energy, feeling down, almost all of the classic symptoms. I told her to get ahold of defy and get her labs checked, it may be a hormone issue. She did, assuming they would prescribe HRT if anything at all, and the clinic reached back out and prescribed TRT at 10mg per week.
I like Defy but don’t agree. My wife and I go there too. In your case the labs are pretty normal, yes a tad low but not much. iMO you would need several lab draws over a period of time to determine if TRT was needed as her posted labs are close to normal and these values vary depending on timing of cycle. Even if you went that route they have you on the wrong starting dose.
