I can confirm that. If only it was that simple.
Out of curiousity, were the sore muscles the muscles you pinned? I always get soreness in my muscles (glutes, deltoids etc.) After administering an intramuscular injection to said site. It’s not severe (unless I have an adverse injection site reaction which has happened a multitude of times), but pain wise I’d say it’s rather similar to DOMS.
Care to elaborate on this? Potentially this community could get to the bottom of whatever this potential issue with hepatic function is. Have you ever had a liver panel performed?
I assume we are talking about accruing muscle mass at a heightened rate as compared to what you’d potentially gain with natural physiology, if this is the case, literature demonstrates a dose dependent relationship between dose and muscle mass. From what I recall the lowest dose found to have significant performance enhancing effects was like 2.5mg/kg/wk, while using this as a measure is flawed due to genetic outliers with regard to how people metabolise and excrete testosterone,.given you’re labs I’d say it appears pretty spot on lol.
Whether X level gives you X amount of gains is up to many factors, training, diet, genetics (AR density etc, amount of type II muscle fibres and whatnot)
You must understand though, experimenting with supraphysiologic doses of testosterone isn’t without its risks, when used responsibly these risks can be mitigated, though the thought of developing LVH and associated impaired cardiac function is perhaps the scariest potential risk revolving around AAS.
Holy shit … That’s pretty high lol.
Unfortunately, you’re right, testosterone injections don’t give a linear increase, I assume it’s related to the amount a site can absorb at once or something, literature does demonstrate that T from 600mg doesn’t equate to double that of 300mg 
Are you hard gainers training hard enough and eating enough calories including enough protein?
Every muscle in my body is on the verge of cramping whenever I increase my dosages (like now), are start to become very sore at the 6 week mark which is when my levels become stable.
I never feel pain at the injection sites, I don’t even feel the needle at all.
Liver function is great, yet fatty liver was seen on the ultrasound. I have the gilberts gene as well, some believe it’s uncoagulated bilirubin causing the problems and could just be sick care doctors fixating on the only lab value that’s out of ranges.
High bilirubin levels causes yellow skin, not red skin. I an suspect an autoimmune disease because I’ve had a chronic cough for about 20 years and there seems to be no cause.
I’m starting to wonder if elevated E2 could be causing a lot of my problems, high E2 sends my nervous system into overload, hearing, sensory perception is too intense and I wonder if the cough could be related to overstimulation caused by high E2.
I’m not a fan of HCG because it can complicate everything, my advice just for awhile is to stop HCG and just do the testosterone in isolation. HCG can decrease libido and hurt erections.
I believe earlier you mentioned you were overweight, for how long a period would you say you were overweight and by how much were you overweight (like slightly overweight, obese, morbidly obese etc).
Obesity can cause NAFLD (esp if you have type 2 diabetes), how’s you’re glucose tolerance and insulin sensitivity.
Out of curiousity, do you feel feverish or under the weather when you increase dosage? The testosterone metabolite etiocholanolone is immunostumatory and can cause feelings of unwell…ness, you hear guys on cycle talk about the “test flu”, that’s typically elevated concentrations of etiocholanolone (or dirty UGL product lolz), but typically etiocholanolone is the culprit, it’s possible you’re very sensitive to fluctuations regarding this particular metabolite.
If you had autoimmune hepatitis (you mention an autoimmune disease, however I don’t think a chronic cough would be liver related) I reckon youre ALT/AST would probably be elevated, you could get ANA/SMA (antibodies) tested if you’re curious though.
However if you’re cough is autoimmune related I’d probably think it’s some type of chronic airway inflammation. Maybe Dr Mr Dr Mr Dr Mr Professor Rabbi Sir (physiolojik) could give a more clear answer.
Idk if its high E2 or if you’re sensitive to the effects of androgen induced CNS stimulation. Beta Adrenergic receptor upregulation does initially occur… And rapidly (before the effects level out) making you’re body more sensitive to catecholamine release, thus giving you uncomfortable symptoms. I could be wrong though, it’s just a theory I have as to what could be causing said nervous system overload
What do you pin with? I pin with 19-21G needles because they’re cheap, easy to get, and due to the fact I only shoot 1x/wk I don’t mind. Although currently I’m doing ED shots with TNE, so it’s starting to irritate me. (Aaaaaaaa the scaaarrrr tisssssuuueee)
When my dosage is increased I do experience feeling very hot, temperature is 98.8 during the hotness episodes that seem to peak at night time building up throughout the day. I’m told TRT can increase T3 uptake, only I can’t confirm it.
I have pictures of the inflammation in my upper airways, only when I went to do a scan, found nothing. The inflammation moves around from my lower esophagus and upper airways. One common denominator, the more energy I have, the better I feel, the worse the cough. Whenever I was on ineffective TRT protocols, the cough was weak.
I think higher testosterone levels increase immune function, imagine what would happen to a guy that has an immune that’s attacking healthy tissue and his testosterone is increased.
This is interesting, I feel like this may happen to me. Heart palpitations when increasing dose even a little bit could be due to catecholamine sensitivity especially given my COMT mutation. Is there a way to avoid/treat it?
Can always take a beta blocker (need a script), and they can cause shit with insulin sensitivity. Beta blockers block the effects of beta adrenergic receptors. For heart palpitations a cardioselective beta blocker is you’re best bet (Atenolol or metoprolol etc), if you want more details on the pharmacodynamics of beta blockers reply and I can give an in depth reply.
Thank you Unreal, yes that would be great, can’t they cause sexual side effects? Also what about alpha blockers? I read they can help with ED due to blocking the effect of norepinephrine on smooth muscle
beta blockers work by blocking beta adrenergic receptors, there are multiple types of beta adrenergic receptors in different types of tissue, for the heart, the main stimulants (when talking about stimulating increased heart rate/contractile force in response to catecholamine release) is the B-1 adrenergic receptor subtype, thus beta blockers that are more selective to blocking the effects (antagonising) B1 adrenergic receptors will be the most effective at slowing down heart rate/ reducing palpitations and/or arrhythmias.
Beta adrenergic receptors are the targets/ sites for catecholamines such as epinephrine (adrenaline), and I’m almost sure I spelled that wrong, and norepinephrine or however you spell it, blocking these receptors block the effects of ephineprine and however you spell the other one… thus beta blockers are also fantastic for reducing the physiologic side effects of anxiety, I find them immensely helpful for thus (anxiety is a vicious cycle, physiologic sides fuel phychological sides, and it’s a vicious loop until one can be cut off), thus yeetfloopity I have my beta-blocker for that and autonomic instability.
Alpha blocker… eh, there’s more tried and true ways to achieve an erection (I mean you can always try yohimbine (alpha 2 adrenergic receptor agonist), could relax smooth muscle and allow more blood flow, however if you’re looking to slow your heart rate… yohimnine isn’t a great choice lol, kinda counterproductive. Ever try a PDE5 inhibitor, I don’t have ED, but I’ve used Cialis before as I’m an irresponsible moron sometimes and it’s fucking awesome. (just make sure you’re BP isn’t super low, for someone like me, experimenting with a vasodialating medication such as Cialis is actually quite dangerous).
I’m not qualified to give medical advice btw, so take what I say with a grain of salt. Dr Mr Dr Mr Dr Mr Dr Mr Dr Mr Sir Mr Dr Sir Professor Sir Sirrington is the person to ask about this for a more accurate response.
Thanks. I’ll bring it up with my doctor. I tend to not get the mental symptoms of anxiety just the physical ones which makes me think there’s just excess adrenaline for some reason. I also have some urinary issues like narrow stream which I guess could back up the theory - although I did do a urine catecholamines test which came back normal… not sure how reliable the test is though
Interesting discussion. So, I’m not so concerned with building muscle. That’d have been a nice to have. Pre-TRT, my Testosterone levels were between 200 to 300ng/dl and I felt completely fine. Had intermittent erectile dysfunction but a 5mg cialis did the trick.
Originally, I went to doctor because I could no longer sleep at night and was experiencing hair fall for over a year. Turned out it was subclinical hypothyroidism (TSH: 5ish. So, doctor put me on Levothyroxine 100mcg/day and within a few days I felt better and while it did not fix erectile dysfunction, the 5mg-10mg cialis continued to do the trick.
Then after a couple of months of follow-up, lab showed my thyroid is good but Testosterone is still in 200-300 range. So, doctor put me on TRT.
And now my T levels have been consistently above 900 for several months but ED has gotten worse. Even dose as high as 30mg Cialis doesn’t seem to do the trick anymore.
I had expected with TRT, maybe I won’t even need Cialis anymore.
So, the main issue I want to fix is ED - which, in the initial phase of TRT was completely fixed and then came back and now it has been several months but my ED just continues to get worse.
Here are the potential causes I’ve investigated:
Nitric Oxide deficiency
Started supplementing with l-arginine, POM juice, l-citruline
Neurotransmitter:
L-Dopa (mucuna pureins powder, 3g dose), na-l-tyrosine 3g dose, maca powder 3g, 5-htp - 100mg, CDP Choline 750mg, Pinebark extract 750mg
Hormonal profile:
- Testosterone is highest it has ever been!
- E2 is under control 20 pg/ml to 40pg/ml
- Free T above range.
- DHT midrange.
- Prolactin high-range (have tried dostinex and brought it down to lower half range)
- Thyroid is good (Free t4 and Free t3 upper half range, TSH ~ 1.0)
Diabetes:
I’m not diabetic but doctor thought I was pre-diabetic. So, put me on 750mg ER Metformin. Been 6 months now.
a1c is < 6%. Usually around 5%
Lipid profile:
Same time as Metformin, doctor put me on Crestor 20mg ED because cholestrol was a bit elevated. Cholestrol is under control now and has been for over 6 months.
Blood pressure:
Has always been normal. So, I doubt there is any artery clogging going on.
GainsWave/Shockwave therapy:
Did a couple of sessions of shockwave therapy where they send shockwaves to penis and surrounding areas. no improvement.
Porn Induced ED:
I watch very little porn. I used to watch a lot of porn couple of years ago and masturbate few times a day and still have sex. No ED whatsoever. But in the last 1 year, watched very little porn. So, can rule out Porn induced ED.
Now, I don’t know what else to investigate or try. First few months of TRT when I was taking (Testosterone + HCG + Metformin + Crestor + Levothyroxine), I was all good. ED was almost fixed (still had to take 5mg-10mg cialis but effects would last 3 days). But in the last 3 months, even high dose cialis (like 30mg-40mg) doesn’t work. I’ve also tried Viagara etc.
I CAN get hard with physical stimulation + cialis (like if a girl starts to blow me) but I lose erection within a minute.
I’m NOT taking Finasteride. But I do take a bunch of vitamin supplements like B complex, Fish Oil, Vitamin D, Zinc etc.
in my opinion, you could stop use this two medications (rosuvastatin, statins) they are POISON! with just two simple life style changes:
- Cut all high GI carbs
- Intermittent fasting.
- Cut all vegetable oil . except coconut oil and olive oil.
- Increase fish oil and grass fed beef (fat cuts)
- stop use neurotransmitters.
Levothyroxine, T4 only treatment is known to be less effective and people usually have unresolved symptoms. T4 only treatment can convert over to Reverse T3 blocking Free T3 which competes for the same receptor.
The best treatment option is T4+T3 medicine, unless Reverse T3 is elevated, then you would need T3 only medicine. Some people need Free T3 near to the top of the ranges to get the full benefit.
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Rt3 is low. T4 only medicine worked just fine for me. Also, the ED was not affected by Thyroid too much. It got worse after months in TRT. that said, I’ve tried NP-THyroid too and it didnt make any difference. Because I travel a lot, I think sticking to Levothyroxine is better for me because its easier to find thyroxine in other countries but not armoud/np-thyroid.
Thanks. Nerotransmitters - I used temporarily only to rule them out as a cause for erectile dysfunction. I took them for 2 weeks to see if they help. I’ll slowly phase out statins as I improve my diet.
T3 greatly affects neurotransmitters.
very wize decision. the sooner the better.