Iodine replenishment. Check the sticky. Did nothing for me other than elevated TSH.
What’s interesting is , my TSH was always between 2.5 and 3.7 before TRT.
Now my TSH is close to 1.1 in my latest thyroid labs (average from 3 different lab results).
Though my FT3 and others are the same as pre TRT.
Maybe the body sees less need for thyroid hormones in your body since testosterone is optimized. Usually when one hormone is low, others need to compensate. I think my body now is compensating with cortisol for example. Just wild guesses
You were right. My lab result just came in. I do have the deficiency.
(TBG) 13.5 µg/mL 14 - 31
What does one do about TBG deficiency? What is it exactly? If i treat it , is there a possibility that my thyroid will be treated too?
Your body would not be on conversion alone, you still have natural production on thyroid meds, albeit a little suppressed.
As much as a know a substantial dose of t4 that most patients take shut you down completely
I didn’t read all the replies, so I don’t know if this has been said. Your Progesterone is not elevated. The labs have changed their reference ranges. If I remember correctly, they used to be between 0.2-1.4 ng/ml. I used to be 0.7 ng/ml when I was healthy (Not on hormones). Men need Progesterone to balance Estradiol/estrogens just like women. The lab should have kept the old reference range. This new 0.0-0.5 ng/ml (depending on lab) is very incorrect and harmful to patients and doctors. Progesterone levels below 0.5 ng/ml are not optimal. (Mid-range ~0.7ng/ml is good for men). Unfortunately, this means we can longer accurately test Progesterone, which is a travesty. You will need to go by symptoms of estrogen dominance in the absence of elevated estrogen. I recommend between 5-12.5mg sublingual Pregnenolone daily for healthy Progesterone levels for men.
50mcg is a good start.
So turns out my progesteron is low not high?
I have another question.
How comes my Growth Hormone(STH) is almost bottom range and IGF-1 is above top range?
| Growth Hormone(STH) | S | 0.43 | ng/ml | 0,03 - 2,47 | ECLIA |
|---|---|---|---|---|---|
| IGF I | S | 254.3 | ng/ml | 83 - 246 | CLIA |
Are you taking Progesterone, or Pregnenolone? The problem is that if you have high Progesterone levels, the new lab reference ranges will not reflect this. For example, I trialed Progesterone cream and had symptoms of high Progesterone, but when I did a blood test it only showed 0.3 ng/ml. This is impossible, it should have been much, much higher. Probably well above 2.0 ng/ml. In other words, the new labs ref. ranges CANNOT be used any longer for men.
Are you on exogenous GH? Elevated IGF-1 in the absence of GH supplementation could be a sign of cancer. If you are taking GH or GH secretagogue, these will increase IGF-1 because GH converts to IGF-1 in the liver. All the benefits are from the IGF-1, which is the goal to raise from supplementation.
@TRT_Phoenix I do not take GH but a few months ago Ive done NMR of the pituitary and no tumor was found but empty cella. Can the empty cella elevate it? I think this range is also decreased
Also I do not take progesterone, pregnenolone or dhea only small doses of t3, dostinex, metformin and some vitamins minerals.
Maybe the caber has increased the IGF-1?
I’m not a doctor, just an individual that researches extensively. It is possible that ESS can be present with Acromegaly (Elevated IGF-1). Do you have signs of Acromegaly?Dostinex/Dopamine Agonists can paradoxically increase IGF-1 in those with Hyperprolactinemia. However, your IGF-1 is only slightly elevated.
@TRT_Phoenix I already have read the second document and no I do not have signs of acromelagy, but more and more I think it is logical that the dostinex have increased IGF-1 because it increased my LH and I think GH is secreted also in the frontal part of pituitary, right? The empty sella is at the frontal part. I just fear when I stop the dostinex all its positive effects will be gone.
But another interesting thing is while IGF-1 is at the top level the actual Growth Hormone measurement is low in the range, which can be a moment condition of course
@TRT_Phoenix by cancer what did you mean a pituitary cancer?
I think the IGF-1 range is also decreased because the progressive doctors who supplement their patients with GH or peptides try to keep the IGF-1 around 350-400
It’s likely updated technology that led to a new reference range. @johann77 likely has the answer
Whatever the reason for the change in the Progesterone range, it is now no longer accurate. For example, my new baseline Progesterone level is usually 0.1 ng/ml. However, when I supplemented Progesterone cream and retested, my level was 0.3 ng/ml. This lab result does not reflect anything of meaning because in reality it should have been much, much higher than 0.3 ng/ml. In other words, we can’t make changes to treatment with any degree of precision.
Any chance you are mixing up progesteron with 17 OH progesteron?
progesteron ref range dep on method appr <0.2 ng/ml
17 OH progesteron ref range dep on method appr 0.3 to 2.0 ng/ml
Recommended reading paper below and a biochemistry textbook
Nope. I have my old Progesterone labs from LabCorp. 0.2-1.4 ng/ml. I was 0.7 ng/ml.
Labcorp now uses the progesteron assay developed by Enzo, or they outsource the test.
Anyway, the new ref range is due to an updated more specific method. The old higher ref range was due to unspecific signals being picked up.
Elevated levels are most likely an artifact due to interference. The test with the highest specificity the LCMS assay uses a ref range of <0.2 or <0.1
For males Progesteron is completely irrelevant with the exception to detect complete or partial congenital adrenal hyperplasia in early infancy and childhood, respectively.