Does what said here seems reasonable ?
https://www.reddit.com/r/PEDs/comments/18wl90a/the_most_common_toxic_aas_to_the_the_body_and_the/
looks promising and i can’t decide which ped should i blast for my next cycle (deca,tren,ment)
what do you think guys ? should i blast tren or deca ?
What is your interpretation of the study?
What were the doses of each drug that was administered to the rats?
the study looks legit
i don’t know the dosages unfortunately
i mean also the neurotoxicity part
what do you think about it ?
I think every AAS is toxic in one way or another given the ‘right’ dosages. I also think that no other steroid other than testosterone (and maybe anadrol and anavar) have been researched to the extent deca has. This means there is very little historic research done on tren or winstrol whereas deca has been scrutinized much more since it is prescribed and scripted for certain conditions to this day. More research on any drug will ultimately lead to better understanding of how side effects manifest themselves and to what degree.
Regarding the research and dosages involved in the study you posted, it says on page 39:
In order to examine the effects of AAS on primary cortical cell cultures, the cells were administered with 10 μM, 30 μM, or 100 μM of the AAS.
Here’s a response I found from a knowledgeable member on another forum:
Specifically, here, the concentration at which statistical significance was detected for potential apoptosis (programmed cell death) by testosterone, nandrolone, and trenbolone was 100 µM in cortical cells (that which has crossed the blood-brain barrier).
Not only is it physiologically impossible to reach such concentrations in cortical cells, where concentrations are magnitudes lower than blood concentrations, it is absurd to even consider these concentrations in blood.
100 µM ≈ 2,880,000 ng/dL
Two million eight hundred and eighty thousand ng/dL
You couldn’t possibly inject this if you tried to fill up every muscle depot with the highest concentration gear you could find.
Besides that, all the concentrations were absurd that they used, even their lowest. The lowest concentration they measured would require administering more than 6 grams of weekly AAS, just to reach those concentrations in blood, which, as mentioned, are still orders of magnitude greater than that which crosses the blood-brain barrier to reach cortical cells.
All in all, the study design here is totally ridiculous to be interpreted in this manner in which OP & apparently many others read these. It’s not applicable to man.
On page 53 it says:
The difference in esters used (decanoate compared to undecanoate) could possibly affect the outcome. However, with the treatment regime used (15 mg/kg every third day) high systemic AAS concentrations were expected regardless of the ester used.
For a 225lb person this would mean a dose of over 3 grams per week. Anyone using over 3 grams a week of anything, let alone deca or tren is bound to have health issues, neurological or otherwise.
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thanks you dude, well explanation
but how we can convert from 100 µM to mm ?
and why all the studies related to steroids they use very high dosages ?
maybe to make the deficits to appear faster ?
i’m not the poster on reddit by the way