Perhaps the below is not only old news but even the information contained within the following link is false. It apparently discusses, among other things, the alleged “anti-estrogen” activity of Vitamin E. Perhaps someone with greater knowledge than I can attest to the validity or otherwise of its contents. See below:
What’s false about it? Or what do you think is false about it?
Ray Peat knows his info. And the mechanisms by which he describe Vitamin E as being antiestrogenic makes sense… as far as I know he’s been putting info out since the late 60s too…
[quote]EGYnutrition wrote:
What’s false about it? Or what do you think is false about it?
[/quote]
Wasn’t stating whether it was or otherwise. I was hoping others could confirm or deny its validity since there are other posters here with greater knowledge in the area of nutrition than I.
Well if you read is other stuff (all hormonally related pretty much) you’ll know he is an advocator of saturated fat, and does not like unsaturated fats at all because of their potentiality to oxidize and cause damage quickly among other things.
He draws some conclusions of the anti-estrogenic property by showing Vit E fights the negative side of estrogen such as :
Excess clotting related to excess estrogen and E deficiency, causing fibrosis, which Vit E fights
Estrogen increases progstaglandin synthesis, vitamin E decreases their synthesis
estrogen increases the activity of the enzymes COX and LOX, vitamin E decreases their activitiy.
Estrogen releases enzymes from lysosomes, vitamin E inhibits their release. Beta-glucuronidase, one of these enzymes, can release estrogen at the site of an inflammation.
Estrogen often increases intracellular calcium and protein kinase C, vitamin E has generally opposite effects.
The polyunsaturated fatty acids and their derivatives, the prostaglandins, act as effectors, or amplifiers, of estrogen’s actions.
If vitamin E is acting as a protectant against the polyunsaturated fatty acids, that in itself would account for at least some of its antiestrogenic effects.
Besides antagonizing some of the end effects of the toxic fatty acids, vitamin E inhibits lipolysis, lowering the concentration of free fatty acids (the opposite of estrogenâ??s effect), and it also binds to, and inactivates, free fatty acids.
Not sure of the exact mechanism, but through his evidence Vitamin E seems to antagonize the BEHAVIOR of estrogen, whether or not it is an actual Estrogen Antagonist 100 percent wasn’t said in the article.