TRT Shuts Down Ability to Urinate

Pharma TRT
1

Last week I restarted TRT again and within 24 hours my urine became cloudy and within 48 hours I was unable to urinate except for a little squirt in the morning and evening. I started swelling in around the waist and could feel something in the groin area swelling, then I lost the ability to sense an urge to urinate.

When I would be drinking at the end of a meal, I could feel a sensation in my legs 10-20 seconds after swallowing drink of water or tea, it felt as though I was urinating inside my legs. Then eventually my skin started to turn red and felt like burning inside my legs that Iā€™ve tied to eating, the bigger the meal, the more burn in legs which can travel up to my arms, belly and chest if I eat three meals a day.

To keep these symptoms at bay Iā€™m only eating one meal per day until I can see my urologist. I do have problems urinating while not on TRT, in fact I still get the burning in feet, just not to the extent while on TRT. The skin turns red and becomes damaged on the outside, it burns like acid.

My veins pop at night and if I eat three meals, the veins in my feet look unusually swollen and I can feel throbbing in legs and feet. I have had extensive testing with doppler ultrasound five different times while experiencing all of these side effects and the blood return (Vena Cava) veins are showing good return.

Regardless of how many meals I eat per day, I always feel bad 40 minutes after eating, Iā€™m unable to balance well and just feel out of it. My teeth hurt at night when I was eating three meals per day and the lack of urination seems to be the culprit. I got up this morning and sensed no need to urinate.

I have had trouble urinating since before my low T diagnosis, I was originally told TRT would restore erections and improve urinary symptoms but seems to have gone the other way. The blood pressure medicine, diuretic work in the short term and eventually cause extreme pain in left side the area becomes very hard/swelling and if I touch it or bump into sometime, it feels like I have been shot or stabbed.

Stopping the blood pressure medicine gets rid of some of this swelling and pain, but urination issues continue. Iā€™m not expert in urination, but it seems like to me so far my doctors have been treating bladder problems with blood pressure medicine and the blatter canā€™t keep up with waste removal.

Also I want to note that these T injections really affect my muscles which become stiff and hard after an injection and my response to TRT is very fast., My kidneys and liver show very good function, heart/ejection fraction normal. One thing I notice is when urination ceases upon starting TRT, my glucose levels shoots up high.

So the more restriction in urination, the worse my glucose. Iā€™m thinking blatter has muscles and so what if these muscles are become rigid negatively affecting urination?

Thoughts anyone?

2

In theory that could happen or you might have benign prostatic hypertrophy that gets worsened while the prostate gets exposed to more testosterone.

I know itā€™s not the best medicine around as it has side effects but you could try Tamsulosin. Itā€™s an alpha blocker and helps relax bladder and prostate muscles.

If it works then you could evaluate whether the bladder or the prostate is the problem. If you do indeed have BPH you could go for a TURP which could relieve the urinary symptoms and that way you can continue TRT.

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I get side effects on all medicines, my doc actually refused the alpha blocker for fear of stoke if I had to stop it.

Would I be risking sexual dysfunction if I were to do this TURP procedure?

5

@systemlord, some new stuff I learned about this weekā€¦

Thereā€™s a subset of guys who are slow metabolisers of neurotransmitters with COMT, MAO-A and MAO-B, so they get anxious/overstimulated at higher levels. 5-10mg per day (after you subtract the ester) generally represents ā€œaverageā€ production, so isnā€™t optimising T levels, but replacing a ā€œnormalā€ level.

Needless to say this is RARE but would explain your 7mg a day stuff. Have you ever done the whole 23andme thing? Would explain why you donā€™t respond to T in the same way that the rest of us do.

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I do have a DNA kit I have yet to use. If I had to switch to cypionate I would have to reduce dosage down to 4-5mg, 6mg cypionate is too much. The enanthate is weak by comparison at 7mg. I donā€™t feel the same intensity or even get the same levels on the enanthate that I do on cypionate mg per mg.

When I tried 10mg daily, I according to Dr. Saya I had some kind if CNS attack, it was clearly too much and was sure I was about ready to die! I was crazy aggressive when I scoring in at 829 ng/dL FT =?, 697 ng/dL had my FT at 29 pg/mL, yet 497 ng/dL got my FT to 20 pg/mL.

Normal for you is probably supraphysiological for me. I did have Tourette Syndrome at an early age, so my CNS is on steroids so to speak and have had hypersexuality my entire life. I could go 10-15 times per day, 10 times sustained.

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Hey @dbossa. Iā€™m on my 23andme ā€œYour Health Reportā€, page right now. Where would I find that in my https://youxxxx23andme.xxxcom/health/all_reports/ ? I donā€™t see anything relating to that stuff but it could be using a scientific term Iā€™m not familiar with. Or maybe it only shows up if predisposed or have "variants detected?

9

With your medical history I would think itā€™s related to glucose control and the development of diabetic ketoacidosis. The skin rash might be prurigo pigmentosa which is associated with DKA.

Did you get a ketone meter?

I would just stop TRT. Depending on whether you are primary or secondary I would maybe try low dose clomi, itā€™s just less invasive to hormone homeostasis.

Take care and I hope you are doing better soon!

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I donā€™t have DKA according to my docs, I am producing plenty of insulin, I canā€™t use it because of insulin resistance. My ketones are negative, c-peptide is 4.7 ng/mL (0.8 - 5.2 ng/mL), A1C 8.3, month earlier 7.7, month before that 6.6. My glucose levels are 199.

My legs are freezing cold, I wake up in the morning shivering uncontrollably and take an hour long shower just to warm up. My diet is improved and yet my diabetes is worse.

So if my diabetes is worse, why did TRT make urination worse and not better? Last April my A1C was 6.6 and I had the same urinary issues on TRT. Something is cutting urine flow and TRT taking it to the next level. PSA is .8, lowest Iā€™ve ever seen it. These test results were taken yesterday.

The skin redness only happens when urine flow is reduced, never do these happen separately.

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Sorry to hear about your situation.

Then itā€™s not DKA. I was mainly going by the symptoms of high glucose and the skin rash, but if ketone bodies are negative than thatā€™s simply not DKA.
I also donā€™t know if this would anyway be related to your urination symptoms, but as A1c is creeping up there is definitely something going on regarding your ability to control glucose which can bring on a lot of nasty other effects. Homeostasis of magnesium, sodium, calcium and potassium are impacted by uncontrolled glucose levels which in turn can cause all sorts of problems with muscles and as you stated correctly bladder is also controlled by a sphincter.

Did you talk to your doc about the need for insulin therapy? You might be producing plenty of it on your own, but it might just not be enough to control glucose.

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Dudeā€¦ the answer here clearly isnā€™t trt. Youā€™ve tried again and again with the outcome only being a worsening of health ailment

Youā€™ve been very overweight for a very long period of time and health consequences associated with the systemic proinflammatory state, endocrine abnormalities etc induced (probably) entirely due to obesity have arisen. What you need to do ASAP is get glucose under control, check electrolyte balance via bloods

This isnā€™t good at allā€¦

Yes, but how many times per week do you engage in adequate physical activity. Dietary modifications can go a long way in terms of improving overall health status, but if youā€™re still eating a lot of high GI foods, not exercising and inadvertently eating over youā€™re BMR (while not exercising)ā€¦ regardless of whether the food is healthy you wonā€™t lose weight, youā€™re condition wonā€™t improveā€¦ explosive exercise in particular will increase cellular sensitivity to insulin

Regarding youā€™re diet, what percentage is composed of processed foods? Given you seem to be extraordinarily sensitive to almost every medication that exists, thereā€™s a chance an adverse reaction from eating may stem from an adverse reaction to chemicals used as preservatives or flavouring in food. Otherwise a vitamin/chemical imbalance

I think you ought to see an endocrinologistā€¦ whilst you may not like them, they may not be well versed in regards to TRT, ailments like this is typically what they excel in.

God damnā€¦ youā€™re water bill must be insaneā€¦

As to urinationā€¦ if youā€™re prostate isnā€™t enlarged, the bladder wall is composed of smooth muscleā€¦ regulation vascular tone is somewhat influenced by numerous potassium channels

Consistently elevated glucose fucks with pottassium (amongst numerous other electrolytes) regulation

Testosterone is a fairly potent 11b-hsd inhibitor which can interfere with the metabolism of cortisol/ lead to mineralcorticoid excess. Test/anabolic steroids also decrease cortisol, a catch 22ā€¦ but youā€™re dose is so low I doubt itā€™d have much of an effect regarding decreasing cortisolā€¦ of which also interferes with electrolyte balance.

Bottom line is, I actually think youā€™re extreme responses to many medications may resolve if/when you become healthy regarding weight/bf% and when you get youā€™re (acquiredā€¦ mind you this is acquired from years of living a bad lifestyle) type 2 diabeties under control. I canā€™t stress to you how dangerous walking around with unmanaged diabeties is.

I do believe you have preconceived notions about certain medications and thus placebo (and legitimate side effects) will be youā€™re enemy if you end up using meds (typically a biguanide like metformin) give them a chance before deciding ā€œif doesnā€™t workā€ā€¦ and no, a single dose of metformin is highly, highly, highly unlikely to induce any adverse (or beneficial) effect.

Seriously though, you shouldnā€™t be on TRT in youā€™re stateā€¦

  • drop the weight (and yes, you can lose weight even with hypogonadism, I was about 15%BF with a TT ranging from 150-250, I wasnā€™t muscular, but I wasnā€™t fat either)
  • get the glucose management under control

Then think about TRT (Iā€™ll bet youā€™ll also be able to manage far higher dosages without significant side effects)

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I think you should try with another doctor. I believe out there there are doctors that can manage your hormonal optimization even in your complicated state.

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My potassium took a hit after starting TRT and glucose levels shot up right after the injection. Iā€™ve been having problems with potassium and my teeth turning yellow as the calcium is being stipped out of bone and teeth. I can actually feel this occur and it is a strange feeling. My muscle were spasming as well. I can feel my insides being burnt, then shortly after this happens my skin starts turning red. Eating triggers most of these events.

My endo is confused, TRT should improve my diabetes, not make it worse. How I feel after my first injection is how I used to feel when reaching a stable state, expect now after only one shot.

15

Youā€™ve posted so much crazy shit on this forum, I did not know what to think. Still donā€™t. There is a lot that does not make sense. Some things made me think, placebo effect, OCD, hypochondriac, etc., but at some point it seems you can not make this stuff up. Have you ever thought about consulting with a geneticist? Maybe someone affiliated with a major university? Has to be an explanation for all of this, and I do not believe it is between your ears. Iā€™m thinking a typical endocrinologist has not seen anything like this, or even close. You may even need someone with some sort of subspecialty in genetics. Hope you find the answer(s). Good luck.

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My only thought is Iā€™m unable to use insulin and TRT demands more of everything, so my vitamins and minerals are targeted instead, TRT usually means keytones are made.

There is no OCD or anxiety, just good old frustration with Kaiser docs. My endo the other day said diabetes is 100% diet related, as if 91 ng/dL has nothing to do with any of it. My diabetes worsened since stopping TRT, diet improved and Iā€™m losing muscle mass quickly.

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If your doctor refused the alpha blockers for fear of stroke then they are definitely out of the equation. Did you ask your doctor about some herbal alternatives like saw palmetto, red clover and African tree bark? I would give those a try if your doctor approves.

Although the TURP procedure has vastly improved over the years there is still side effects. Sexual dysfunction and retrograde ejaculation are some of them. It doesnā€™t happen on most patients but the risk is still there.

Another alternative to TURP is GreenLight Laser which is becoming very popular lately although a lot more expensive. If insurance covers it then itā€™s worth more than the TURP as side effects are a lot less.

However you definitely need to find out where the urination blockage is coming from before you figure out a treatment plan. If it was me I wouldnā€™t take my time with this but I would find a good doctor ASAP. If you donā€™t trust doctors in America there is always the alternative of traveling to Europe in countries like Germany and Austria. I would definitely recommend a university medical hospital.

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I canā€™t remember, do you have Sarcoidosis? Are you on Metformin? What is your calcium level?

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For the love of god, people, itā€™s time to encourage this guy to leave this website, not throw new ideas at him.

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I donā€™t think TRT is going to help him, but I would still like to help him be a little less broken.

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Your intentions are pure, as are all the intentions of everyone who try to help him. The problem is, itā€™s the 28940328950385 diagnoses and ideas and ā€˜treatmentsā€™ that are killing him. Heā€™s morbidly obese and diabetic and has doctors dealing with him all the time, telling him whatā€™s killing him, and heā€™s just spending half his time not listening and the other half insulting doctors on here.

I genuinely think leaving this website would help him be less broken. A forum full of people diagnosing themselves is poison to somebody whoā€™s incapable of using Occamā€™s razor.

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