TRT: Protocol for Injections

I had read up on the thyroid sticky and two docs said my Thyroid was good. My last T3 Free was 3.5 pg/mL Free Thyroxine 1.26 ng/dL and TSH was 2.130. And my RT3# was supposedly in ratio too. What do you think of numbers?

TSH=2.13 should be closer to 1.0 and your body temperatures will be useful.

Temps have been 96.3 to 97.1. I had a naturopath and traditional doc who wouldn’t treat thyroid. I also took some iodoral but didn’t feel good at all when i took it. I eat iodized salt though.

I’ve read through all 18 pages of the thread—thank you, KSman, for your input. There’s is, no doubt, a consistent and logical method and message here.

JDR12, Feeling bad when taking larger amounts of iodine may involve selenium deficiency or possible auto-immune disease, which can be selenium related, or one has a load of bromines occupying locations where iodine should be stored and the higher doses of iodine are liberating the bromines which can make one feel bad, and stink, while the bromines are been excreted. Some things to consider.

There are bromines in some medications, fabric, carpet and foam fire retardants. There are bromated vege oils in some drinks to keep citrus oil flavoring in solution and these should be avoided. Bromines accumulate in the body and should be avoided. Bromines and iodine are chemically related and having bromines in your body interferes with iodine.

It’s funny you know I was really struggling dialing it in so I hired somebody…

He believes in 2x/wk protocol…

And I am much better off than I was…

We are going 70/125/.25 (2x/wk)

HOWEVER…

I feel that the Adex is spaced too far apart… At about the 2.5 day mark I can feel estrogen kicking in.

And I have lost a lot of benefits of the hcg.

SO…

Maybe 3x/wk protocol is better

40/250/.25 (MWF)

Waiting on labs…

But feeling like KsMan original protocol is the closest haha

How does everyone feel about testosterone undecanoate vs testosterone cyp/eth with regard to effectiveness as well as decreasing the peaks and valleys?

The delivery rate by removal of the ester group to yield bio-identical testosterone is slower, creating a longer time release action. Other than that, testosterone is testosterone. Heavier ester groups have this characteristic. Note that the dose needs to be higher because the weight of the ester group reduces the testosterone yield.

If you inject T cypionate or ethanate frequently, there would not be any therapeutic advantage of t-undecanoate other than fewer injections. But there are always other dimension to problems and in this case, longer acting testosterone esters may lead to situations where doctors are asking patients to have injections in the office [$$$] with longer intervals which can still lead to peaks and crashes.

T cyp and T eth will always be the the least cost options in markets were they are available.

Guys I am new here and could use some serious help. I suffered from classic low T for two or three years, the final straw was the erectile problems. I used cialis and viagra to over come that issue but finally had my T levels checked in June fo 2015, sure enough my level came back low 211. I went to the urologist and I dunno if he is taking me seriously OR if I am expecting to much to soon. he put me on 200mg of Cypionate injection every 3 weeks. While my energy levels have started to improve, i just got my second pin and still no major improvement in ED. This is killing me!!! I’m losing my mind!!! I have a beautiful gf who i would like to be able to ā€œbe withā€ but can’t. This is seriously affecting me mentally, emotionally and killing my relationship!! What are your thoughts guys. 41 year old male, fit, t-level and onset of treatment 211.

This is a sticky. Start your own thread Valen and then copy/paste your threads link in KSman is here thread. Please also post all available lab work you have with ranges.

Why the arimidex?

T aromatizes to E2 in the body, a natural process. The T–>E2 conversion is done by the aromatase enzyme. Arimidex/anastrozole is a competitive aromatase inhibitor. Typically, guys on a 100mg T ester [cyp/eth] need 1.0mg anastrozole per week in divided doses. Because it is a competitive drug, serum levels of anastrozole need to match serum T levels to get a given E2 level. E2=22pg/ml is a good target. So T levels need to be steady for all of this to work right.

Few guys do not need any anastrozole. The dose is adjusted to get near the target level E2=22pg/ml. Dose is adjusted after E2 lab work. Examples: E2 lab is 28pg/ml - change dose by a factor of 28/22. Lab E2 is 16 - change dose by a factor of 16/22. Very easy.

There are guys, not rare, who are anastrozole over-responders. They typically require 1/4th of the expected dose. They can feel bad until they get things right.

If E2 is elevated, one can slide back into a state where most of the benefits of TRT slip away. E2 management is typically mission critical. Do doctors understand this? Mostly not and some will not even test E2 because ā€œmen do not have E2ā€ and then will not prescribe anastrozole because it is a female cancer drug. They can’t see that it can be used to modulate E2 levels. Most doctors are idiots.

As a rule of thumb, its 1mg/week per 100mg T per week. If you increase T by a x%, you need to increase anastrozole by x% to maintain a given E2 level. You can correct anastrozole to increase T levels and correct anastrozole to increase/decrease E2 at the same time and get good results. Really, the dose depends on serum T levels. For guys who need 300mg/wk T to get where others are at 100mg/wk T, there anastrozole needs will not be greater by a factor of three. There are rules for normal guys, but you need to know how these vary with guys who have differences. Even good docs will get lost at this point.

There are 7 stickies in this forum. One is estrogen specific.

KSMAN
I have not been to this site in some time, my question is, why only 100ml of Cypionate now? When I first read all of the stickies it was 250ml. Should I change and do what is the new sticky?

TS, something has you confused. 250mg has never been recommended as a starting dose. Perhaps you are recalling that some T is available at 250mg/ml while most pharma grade is 200mg/ml.

Young virile males produce around 10mg T per day, or 70mg per week. 100mg T [eth/cyp] yield around 70mg after the ester groups are removed.

There are a few who are hypermetabolizers of T who need 300 mg T per week to achieve levels that most get with 100mg T per week.

The stickies never did change in this regard.

We also suggest 250iu hCG EOD to preserver the testes and you may also be recalling that.

Do you need to create your own thread and post labs and protocol? Your case should not be discussed in a sticky.

If injecting eod, do you consider 6 or 8 days as 1 week

Thanks
Dave

EOD is a 14 day cycle of days.

I wanted to update some additional information regarding HCG. Before I was privy to the info I prepaid at a compounding pharmacy for HCG in sublingual tablets. After some direction from KSman who indicated that hormone peptides sre too large to be absorbed sublingually and are destroyed if ingested I decided to have a little experiment since I had already paid for the HCG and had it on hand.

Sublingually I’ve been taking 250 iu’s of HCG every day for around 7 days now. This morning I purchased a pregnancy test which tests HCG in the urine and I failed the test which confirms that even true and real HCG cannot be absorbed via any other method except injection. I just wanted to share with anyone who may be reading this considering purchasing HCG in any other form besides injection.

That is a great fact to have on hand!

A study in India explored nasal spray hCG and with lab methods they could not detect serum hCG.

There are similar scams for both hGH and hCG; nasal and oral.

Are you going to confront the pharmacy?

Thanks KSman, so using your protocol I would take 200mg test c/e and 2 mg Ameridex divided by 7 with 250 in hcg eod?

200/7 mg EOD or 100/3.5 mg EOD for 100mg/week
yes to Arimidex/anastrozole and hCG