There’s a popular product that I’ve been reading about - it’s essentially a transdermal version of Resveratrol. Now, I’ve been reading the ingredients, and once again, Biotest makes a much better product at a much better price. However, I’m still intrigued by the idea of administering REZ-V transdermally, since many users report exceptional SERM-like affects.
My question is this: How would I go about turning the Biotest REZ-V pills into something that I could use transdermally? I know there are kits out there that come with solvents, but would something like DMSO work as well? Also, I know this is a beginner question, but how do I know how much REZ-V I can get into each spray bottle before it’s full?
What you’d need to do is establish a concentration. You’d need something that isn’t too much REZ-V per ml, because then you might just have it sticking to your skin. You also don’t want too little or you’ll have to bathe in the solution. This is the main factor deciding how much you can fit into a spray bottle.
Secondly, I would try to avoid DMSO, but it would work if you really want to try it. I know people on here use it sometimes, but there are better solutions, look into it on the steroids forum and you might find something.
Basically get a pill cutter or crusher or even a mortar and pestle and just grind the pills up and mix them into the solvent, this will get you what you’re looking for. If you wish not to do that, there are some resveratrol supplements in caps instead of tabs.
[quote]Mod Brian wrote:
You can already do this with the new REZ-V.
Just open the capsule and rub the contents on your skin.
No DMSO required.[/quote]
Is that a joke?
How would a solid pill dissolve enough without any other preparation and be absorbed into the skin at a rate/efficacy to simulate the effects of transdermally administered resveratrol?
Unless the new formulation of REZ-V is liquid pill form and NOT solid like the old formulation. Even still…
[quote]PonceDeLeon wrote:
Mod Brian wrote:
You can already do this with the new REZ-V.
Just open the capsule and rub the contents on your skin.
No DMSO required.
Is that a joke?
How would a solid pill dissolve enough without any other preparation and be absorbed into the skin at a rate/efficacy to simulate the effects of transdermally administered resveratrol?
Unless the new formulation of REZ-V is liquid pill form and NOT solid like the old formulation. Even still…[/quote]
I think the new REZ-V has the nano-dispersion gel.
[quote]hockechamp14 wrote:
I think the new REZ-V has the nano-dispersion gel.[/quote]
good eye. the new formula definitely has lauroyl macrogol-32 glycerides in it which i believe is the nano-dispersion vector, also gelatin which must be the capsule itself. not to mention twice the dose.
My bad, then. But still…you can’t just rub a gel on your skin and expect the same effect as a compound that’s MEANT to be asborbed transdermally…right?
[quote]PonceDeLeon wrote:
My bad, then. But still…you can’t just rub a gel on your skin and expect the same effect as a compound that’s MEANT to be asborbed transdermally…right?[/quote]
Wow. This looks amazing. Honestly, I can’t even begin to explain how high the quality of the products are that Biotest produces.
This is going straight into the transdermal. I’m thinking of using the overpriced one that the other company is selling as a starting point for dosage, and use the generic transdermal kit, along with a small amount of DMSO as a solvent. I was little worried about using the previous REZ-V pills, but with the gel - well, I have no worries anymore about transdermal absorption.
I’ll post back in a couple weeks when I finally get the final product finished and ready for testing.
[quote]Schmazz wrote:
Wow. This looks amazing. Honestly, I can’t even begin to explain how high the quality of the products are that Biotest produces.
This is going straight into the transdermal. I’m thinking of using the overpriced one that the other company is selling as a starting point for dosage, and use the generic transdermal kit, along with a small amount of DMSO as a solvent. I was little worried about using the previous REZ-V pills, but with the gel - well, I have no worries anymore about transdermal absorption.
I’ll post back in a couple weeks when I finally get the final product finished and ready for testing.[/quote]
While Biotest products are fairly priced, this may truly be a steal for transdermal possibilities.
Tarnsdermal application should result in higher absorption than orally if done correctly. Let me know how your concoction comes out. While you have to exercise caution I have heard of some people applying concoctions with DMSO (Dermacrine) to scrotal are to get even 30 percent higher absorption than other transdermal areas. Many people also like to avoid DMSO for various reasons.
If it was in a patch it would be considered a drug probably and require some serious money on R&D.
I want an article on using REZ-V topically. If the dispersion gel applied to skin is enough to get a much higher effective does than orally this should be discussed by Cy or one of the other scientists. Also how much higher absorption orally with the dispersion gel versus without.
[quote]icecold wrote:
Tarnsdermal application should result in higher absorption than orally if done correctly. Let me know how your concoction comes out. While you have to exercise caution I have heard of some people applying concoctions with DMSO (Dermacrine) to scrotal are to get even 30 percent higher absorption than other transdermal areas. Many people also like to avoid DMSO for various reasons.
[/quote]
I like the fact that DMSO is a free-radical scavenger. I think that the two-fold benefits (anti-estrogen and free radical elimination) would make for an AMAZING product. Although I’m not sure I’ll be applying it to the scrotum area…
And yes, Dermacrine was the other product I was looking at, but it looks like I can get about 2-3 times the product for the same price, with it possibly being absorbed at an even greater rate.
Any word on when the store will show the updated REZ-V ingredient list? Would be nice to see confirmation that I won’t be buying the tablet form but instead the softgel form with the transdermal base.
Also, it’s unusual to see a resveratrol product description without a specification of how much of the resveratrol is trans-resveratrol. Cheaper products tend to be 50% t-res, which means 50% of the resveratrol powder is the inactive cis-resveratrol and other impurities from the plant source, like emodin.
If we’re talking about a transdermal formula, I’d really like to make sure we’re talking about 99% trans-resveratrol.
[quote]rabagley wrote:
Any word on when the store will show the updated REZ-V ingredient list? Would be nice to see confirmation that I won’t be buying the tablet form but instead the softgel form with the transdermal base.
Also, it’s unusual to see a resveratrol product description without a specification of how much of the resveratrol is trans-resveratrol. Cheaper products tend to be 50% t-res, which means 50% of the resveratrol powder is the inactive cis-resveratrol and other impurities from the plant source, like emodin.
If we’re talking about a transdermal formula, I’d really like to make sure we’re talking about 99% trans-resveratrol.[/quote]
Most commonly quality trans-resveratrol extracts are 50%, but also comes in 98% and 99% as you are aware. I would assume it is at least 99% pure, but they claim it is highly pure and very close to 100%. I really believe they do have their own extraction process and are not simply buying a 99% extract from China and claiming it to be near 100% purity with their own extraction process.
I am more interested in the transdermal possibilities and could care less about 99% versus 100%, but for transdermal use you do want it as pure as possible. I am still not sure how well the resveratrol is absorbed with the nano-dispersion gel transdermally and would like some feedback from Cy or one of the other scientists. They are still recommending that you take it orally and I do not expect this to change. The moderator seems to think it would work well with transdermal application. I think it really depends on the particular chemical for how well it works. How well transdermal absorption with nano-dispersion gel and resveratrol works however has not been officially confirmed by Biotest. It may also increase oral absorption, but again how much I do not know.
This forum is lightly moderated, but they do not like too much talk on these types of topics. I will only say Biotest has an excellent reputation of quality and being straight forward with its customers. If they see we have an interest in the possibly of using this product transdermally they may answer our questions. If it works well transdermally I can only imagine their sales would increase considerably for both those wanting to decrease estrogen as well as for those interested in general health benefits.
[quote]rabagley wrote:
Any word on when the store will show the updated REZ-V ingredient list? Would be nice to see confirmation that I won’t be buying the tablet form but instead the softgel form with the transdermal base.
[/quote]
I think it already has. If you look, the actual label is different, and the supplement facts now shows the 600mg per serving.
Plus, as ubl0 pointed out, the other ingredients lists lauroyl macrogol-32 glycerides, which are also listed on the HOT-ROX label, which also uses the nano-dispersion gel.
I just finished up using the REZ-V mixed with DMSO run. I found it to be an amazing product.
First and foremost, I’ve had a case of Gyno since about the age of 15. It’s been nothing major, it’s about the size of a penny. Anyways, after about 1-2 weeks of use (200mg per day, at night) I noticed that my nipples were less sensitive. At about week 3-4 I noticed a decrease in the size of the gyno. Obviously this stuff worked.
Now I’ve never used the REZ-V in straight capsules, but I found this method to work very well. I noticed that it didn’t mix with the DMSO quite as well as I would have hoped. Every now and then I would get some clumps when I squirted out my “concoction.”
Two thumbs up for the transdermal REZ-V. And seeing how it didn’t mix as well using the nano-gel, I would NOT recommend this without using Biotest’s version. I highly doubt it would even mix at all.
I think there might be something to this. I have been applying REZ-V straight to my skin for reducing breakouts. Only used a few times, but it seems to be working very well. All you have to do is pop the pill open and start applying it to your skin, wherever you need it like a peroxide cream. It will soak in very quickly. Allow to set for 1-2 hours, don’t go out in public the 1st time without looking in the mirror first. Your skin might look a little different, and very shiny. Everything washes off. =P