I have been on .7 ml testosterone cypionate weekly for a little over 3 months. I have been pinning .35 on Mon morning and Thu afternoon. I am also taking 1 mg anastrozole weekly The numbers above were about 2 hours after my .35 shot so total could be a little high. The men’s clinic seemed happy with the E2 level but I have read that may be low for my total test. Shoudl I stay on the AI, reduce it or go off of it completely?
How do you feel
1 Like
I knew this would be asked… I feel pretty good but not like life changing good. I don’t really have a reference to how I should feel though. I am 58, libido is good, I have good energy in the gym and seem to be seeing decent gains although I am mainly trying to get rid of the Covid 25. I do have that down to the C12.
I think the E2 is likely too low. I’d see how you feel with about half the AI.
1 Like
Sad indeed, because I have seen men diagnosed with osteoporosis at this level. A lot of these clinics aren’t run by actual doctors, doctors write the scripts remotely but someone else who doesn’t know what they are doing runs the show.
I have high estrogen on TRT and no problems, it helps with fat loss, diabetes control and is one of the many benefits of TRT. Most men don’t need AI’s.
A healthy normal estrogen is 20> pg/mL.
You’re supposed to test at trough, right before your injections.
1 Like
I think your e2 is too low and you shouldn’t down-regulate it unless it’s necessary to (meaning when you experience high E symptoms).
200 mg/ml Test Cyp? 140 mg TC weekly?
Why are you on AI? From the start of treatment?
TT concentrations would be in ng/dl and E2 in pg/ml for typical US labs.
They told me I needed to be on AI right off the bat. I am little nervous about going off completley at this point. I will probably cut it half and see how I feel and then proceed from there
1 Like
Good sign you should find another provider. Yes at this point I would titrate down as suggested by others and reassess dose response every 6 to 8 weeks.
You are also aware of supraphysiologic elevation of your TT levels and comfortable with risk/reward there?
Yes and I was concerned with the high number and will more than likely do more bloodwork in 3-4 weeks with 1/2 the AI. I was headed out of town for a family emergency and had just pinned when I realized I needed my new supply. The got me in that day for bloodwork but it was only about 2 hours after pinning. Ideally I would like to get my TT in the 8-900 range…
Number above should be pretty close to trough. 2 hr after injection won’t read a markedly higher value than trough based on reasonable range for absorption half life of Test Cyp. Good luck!
Based on what you shared above 80-100 mg/week should put you close to 800-1000 ng/dl trough.
Thanks for your help. I am trying to educate myself so I can have an intelligent converstion with the doctor. I did not mention the free test number was 25.6 ng/dl. I am currently doing .7ml weekly in 2 equal shots. Do you think switching to .5ml weekly also in 2 shots would get me in the 800-1000 total? At that level should I stop with the AI completely?
Should get you pretty close. Yes at this point I would titrate down on AI as suggested by others and reassess dose response every 6 to 8 weeks. At 100 mg/week or even 140 mg/week they should not have started you on AI until you got bloodwork after 6 weeks and then only as needed for symptoms or extreme elevation in E2.
This graph gives you a decent estimate of range on expected mean TT level vs weekly dose of Test Cyp.
You would be near the higher side of the estimated range based on blood work you shared.
That’s a red flag, this comes from the bodybuilding world and has nothing to do with TRT. None of these people know what the fu** they are doing, they are just selling product and services for money.
They don’t even understand male sex hormones or know that 16 pg/mL is not healthy or normal.
AI’s can be responsible for removing mineral from your bone, cause hair loss and mess with your lipids. There are no studies showing men benefiting from AI’s on TRT.