Total, LC/MS/MS vs Total Immunoassay

Pharma / TRT Testosterone Replacement
1

This isn’t a ‘case’ post. It a question about the reference ranges Quest Diagnostics.

For years the test ordered by my endo was “Testosterone, Total, LC/MS/MS” with a ref range of 250-1100 ng/dL. This last test (that was ordered by a PA) was “Testosterone, Total, Males (Adult), Immunoassay” with a ref range 250-827 ng/dL.

With the latter test, my results were 831 ng/dL so now she want to reduce the dose.

Anyway I was curious to know if anyone knows the difference between these tests and has an opinion on the most appropriate test for TRT.

Thanks in advance for your reply.

2

Don’t know about the different tests only that insurance companies don’t want patients in the 800 ranges. When I scored 829 ng/dL back in Nov my treatment was canceled until I could show a reduction in levels below 800 ng/dL 90 days later.

3

bump