Just switched from clinic to PCP doc. On 100mg T and 250 hCG/week. No AI. I have been on TRT for two years, never really had an E2 problem. Just got bloods. Doc ordered Total Estrogen and not E2. Total Estrogen range 60-190. Mine came back 666.4. I just ordered a new test for E2 sensitive. I am freaking out right now. Why is my total estrogen so high? Should I be worried?
Total estrogen is pretty meaningless without context. E2 is what’s important. Your doctor wasted perfectly good blood and freaked you out for no reason.
Of course it’s getting the total of all estrogens. That’s the name of the test for Christ sake.
The question is asking if this is pretty normal for it to be 3-4x the normal upper limit due to TRT or not? I’m curious why it goes that high too, even if it “doesn’t matter”. I’d say not enough guys test total E to be able to answer that question though.
I think, with us on TRT, it’s converted from estradiol and maybe with some, androstenedione. I would guess it’s normal for total E to be high in TRT patients, but I’ve never checked it. I have seen situations like the OP’s, guys treated elsewhere, getting total E tested and it is very high, they are also freaking out. They talk around, end up in the office, we run labs and they come back with a mildly elevated E2 level, or even in the 70s.
I probably should know more, but because E1 and E3 effects are so minimal, I’ve not thought much about it. Might be interesting to run both tests on a few guys.
If you can function sexually , erections & orgasm I wouldn’t get worried. Many guys have high numbers and they function normally and all is good.
When I got out of range my libido and erections disappeared and it was time for me to get very serious and do something to get back in balance.
Aside from paranoia, do you have any symptoms of high e2 (which is the only one we care about)? If not then you need to calm down. It does you zero good to get worked up over something that’s absolutely meaningless. My e2 would blow your mind. It causes zero issues. Numbers mean very little without the context of symptoms. Nobody treats numbers, they treat people, and people either have symptoms or they don’t.