More thoughts on Aromasin: dosage recommendations vary from 25 mg/ED to 12.5 mg/ EOD…
this has a pretty fast half-life (9 hours or so. in contrast, tamoxifen has a rather long half-life (5-7 days) ), so adjusting dosages can be done relatively quickly and easily. i’d start high (25 mg/day), and go from there…
one needs to recall that tamoxifen binds to the estrogen receptor. aromasin is an irreversible steroidal inhibitors, and forms a permanent and deactivating bond with the aromatase enzyme.
since aromasin is an irreversible aromatase inhibitor, there should not (theoretically) be any estrogen rebound. as long as testosterone isn’t absurdly high, estrogen should simply aromatise at a normal rate. the aromatase enzyme that has been deactivated by aromasin will remain that way. (however, letro and a-dex are reversible…)
if you stopped both of these at the same time in PCT, then not only would estrogen be able to attach to the ER, this would also occur at the same time that overall estrogen levels began to rise due to cessation from the AI.
based off this information, i would run PCT similar to this:
8 week test prop cycle
PCT:
Week 9-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 10-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 11-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 12-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 13-Aromasin (25 mg/day)
12 week test enanthate cycle
PCT:
Week 13-Aromasin (25 mg/day)
Week 14-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 15-Nolvadex (20 mg/day), Aromasin (25 mg/day
Week 16-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 17-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 18-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 19-Nolvadex (20 mg/day), Aromasin (25 mg/day)
Week 20-Aromasin (25 mg/day)
(if 25 mg/day of aromasin is too high, then one would taper down as needed, obviously)