@systemlord knows a little bit more than most
Just got some of my results from Dr Rob
And my ferritin is above the normal range
at 401
Now read this …
Here’s a link to the website
https://www.lifeextension.com/protocols/metabolic-health/hemochromatosis
Iron Overload and Endocrine Dysfunction
Hormonal imbalance is a significant problem among individuals with primary or secondary iron overload (Noetzli 2011; McDermott 2005; Van deursen 2003).
Excess iron accumulates in the pituitary gland and disrupts synthesis of gonadotropin-releasing hormone (GnRH), which is responsible for stimulating the production of sex hormones from the gonads (i.e., testes and ovaries). The consequence of this disruption is abnormally low levels of important sex hormones like testosterone and estrogen (Van deursen 2003; McDermott 2005).
However, pituitary dysfunction alone does not account for all the hormonal perturbations observed in all iron overload cases (Walsh 1976). This can be partly explained by another phenomenon observed among some iron overload patients - elevated **sex hormone binding globulin (SHBG)**levels; although the mechanism for this elevation is not entirely clear (Gautier 2011).
SHBG is a transport protein that carriers sex hormones through circulation. The problem, however, is that when hormones are bound to SHBG, their ability to bind and activate their receptors is greatly hindered. So, when SHBG levels are elevated due to iron accumulation in the liver, hormonal signaling may be disrupted (Selby 1990).
Thus, iron accumulation in the brain and the liver among those with iron overload may precipitate considerable hormonal irregularities, which can lead to a barrage of complications ranging from diabetes to cardiovascular problems and loss of libido to osteoporosis (Rochira 2006; Corona 2011; Dandona 2011; Dandona 2010).
An unfortunate reality is that many conventional physicians may not appreciate the role of iron overload in hormone-related complications (Cundy 1989; McCarthy 2002). Therefore, it is likely that many patients whose hormone-related ailments may be attributable to excess iron levels are not properly diagnosed and treated.
Life Extension suggests that individuals with known or suspected hormonal imbalances consider blood tests for iron overload . Likewise, individuals with iron overload should consider blood tests for hormone imbalances. Identification and treatment of these commonly concurrent conditions may improve quality of life for many people.