So I want to discuss this for a second
The idea boldenone is uniquely nephrotoxic comes from the following
- rodent models/animal studies looking at boldenone’s effect on the kidney
- boldenone supposedly increases RBC production more so than other AAS… erythropoietin is produced within the kidneys therefore boldenone clearly imparts a stronger effect on the kidney in this capacity
But changing the delicate balance of the RAAS would also be a consequence of a steroid that is highly nephrotoxic… is significant hypertension common with boldenone?
There is a condition called focal segmental glomerulosclerosis that is often seen amongst bodybuilders who use AAS for long periods of time
How AAS can cause FSGS is multifaceted… but altered protein metabolism, they cause glomerular hyper filtration and whatnot which contributes to FSGS
take a look at the rodent and animal studies on boldenone… now look to see if you can find identical studies looking at nandrolone, testosterone, trenbolone etc and the effect they have on the same parameters the boldenone studies look at
You can’t really find them… researchers happened to look at boldenones impact on kidney health in rodents… I recall seeing one study in humans thst inferred perhaps boldenone altered protein metabolism more so than other AAS, but it was an observational study looking at bodybuilders running cycles and the guy running EQ was running like four other compounds…
with that in mind, it’s highly likely given what we know about AAS and impact on RAAS, adrenergic signaling etc that all have the potential to cause downstream effects that lead to scarring of the kidneys long term
Some (tren cough cough) are clearly more prone to inducing kidney damage than others
Correct me if I’m wrong but I’ve never seen any reliable evidence suggesting EQ is more kidney toxic than say… deca or test.
I’d believe it if you told me it was more toxic than say… primo…
Anecdotally EQ was the mildest AAS I’ve ever tried barring primo… except EQ increases hematocrit more so that’s potentially a concern if you are prone to developing secondary polycythemia
I don’t seem to get a terrible E2 crash Eben if it’s like 75mg test 200mg EQ etc
Either that or I just don’t feel it when E2 is bottomed out?
I just don’t buy it being uniquely toxic… though I have seen some concerning anecdotes of guys reporting skewed bio markers on bloods from EQ indicting kidney strain to be present but it’s few and far in between and generally these guys aren’t just taking like test and EQ it’s a stack of like test EQ, an oral, maybe some tren etc
And it’s like cycle number 15… so who is to say that’s the EQ, given in Supra doses ALL AAS are implicated in causing kidney damage?
There’s a drug called trestolone that seems to be very kidney toxic and many don’t seem to talk about it (granted it’s a relatively new/novel compound)…. But look at the uncontrollable hypertension many report on that drug… superdrol as well… but everyone knows superdrol is very toxic
Studies on rodents can be extrapolated to relate to humans sometimes, but rodents have different hormonal/metabolic/enzymatic pathways therefore while we can infer if AAS cause cardiomyopathy and eventual heart failure in rodents and we have tons of literature to support the idea AAS causes this in humans (there’s a curve on genetic susceptibility here) the rodent data is somewhat relevant but rodents are clearly more susceptible to some of these effects
We don’t have enough decent research on AAS to know whether a drug like EQ is markedly more toxic… there are some drugs like tren where it’s just so obvious (on bloodwork as well as the way it makes people feel)
Have you seen a lot of kidney damage directly attributed to EQ?