T Cream 60mg/Day - Good Dose? How Much Will T Increase?

Pharma TRT
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I’m not sure that doctor would be receptive to try alternative stuff. Might aswell go to a alternative medicine doctor and explain my condition, or just go the solo route and see what works and what doesn’t work.

I’m just worried that any supplement might fuck my neurotransmitters even harder, but from what I understand they don’t really do that, right? I mean hypericum might cause sexual issues but if you stop taking it you get back to normal because it didn’t fuck your transmitters.

It seems healthline has a ton of sources on inositol, I will read about it in depth as I’ve already seen that side effects aren’t that bad and people were taking it for about a year.

I found icariin, yeah it’s a bit expensive, 55€ with shipping.

Nope. I was given melatonin 6mg every night, I think that helped me in the first two days, sleep was regulated and I did have morning erections, didn’t last long but I felt them.

Since I didn’t know about most of these supplements and only about hypericum, I was thinking about taking it with no other supplements as to not fuck with anything, would this be wise if I were to try hypericum, despite wanting to try the supplement stack you recommended?

Also, what is the worst thing that a supplement can do to your body? Can it really fuck it like a SSRI?

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How do I know if a supplement guarantees high absorption? Most of curcumin I find is 900mg turmeric and 100mg curcumin. Unless it’s doctor’s best curcumin and this shit is really expensive to order but it has bioperine so that’s thrown out the window.

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Is acetylcysteine dose 1200mg 2-3 times a day so 2400-3600mg a day and theanine 200 2-3 times a day so 600-750mg a day?

Theanine doses seem ok, but acetylcysteine at 1200mg+ daily doesn’t seem healthy.

Also, what are the health benefits to these two aminoacids?

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You can read my log. I did exactly what you are saying not to do. Worked out fairly well.

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But did you ever take SSRI’s in your life? Tried to find anything regarding this topic on your log but didn’t find anything.

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I will put together a list of supplements and come back to ask for feedback, it is a lot of information to absorb and I need to study what I need to take and gather all the information so that if I ever need a doctor I have the right info to share.

I appreciate all your help so far, it’s giving me hope.

I took melatonin 3 days, first 2 days it helped, but not sure about the third one, I woke up really tired 2h-3h after going to sleep. Might lower the dose in a few days.

I read that this can fuck you up and give you sexual side effects similar to SSRI usage/PSSD, did you experience any? I’m not going to take it due to the mixed results I’m reading about it. Some people experience better libido, some lost it, but consensus is that Ashwagandha is bad for you.

I’ll come back later with a list of supplements and ask you for your help one more time, I appreciate you taking the time!

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I’ve used Ashwagandha only for short periods, at low dosages and stacked with other supplements to avoid his side effects (mainly curcumin), and considering that during that times I already have some of the symptoms described in the article, I cannot give a sure answer. The only side effects that I was pretty sure to have noticed in the past with the first use, was an extremely sense of tiredness. Another issue with ashwagandha is that it can cause serious thyroid problems.

My actual regimen is not an usual one, and as I said I’m using it only for a very specific goal and for a limited period of time, so I don’t think it could be useful as is for everyone. I’ve just described it for sharing information, not as a suggestion. Take in mind that I also have experimented with that supplements during a lot of years, just a few during a given time and initially I was really scared of even take one!

Because of this I insist on the fact that for now you should only use as few as possibile, and only the safest and most useful for your condition, which in my opinion are icariin (for increased testosterone, erections and trying to posticipate TRT) and curcumin (to counteract possible detrimental effects of icariin and repair your serotonin receptors).

Consider that these two already contain powerful antioxidants and that taking too many antioxidants is not good for health, so adding other supplements should be evaluated and made one step at a time, with careful monitoring.

I’m happy to help, only keep in mind that I am just a guy with a lot of trouble that likes to experiment and not giving up, and I’m sharing what I know and find useful. So ever do your research and be careful, even about my personal opinions!

Returning to an argument more in line with TRT, some years ago I read that in Europe some doctors also prescribe a nonaromatizable androgen instead of regular TRT for managing low T symptoms (especially sexual symptoms), derived from DHT and called mesterolone, which is not as suppressive as regular testosterone (if what I remember is right, at low doses it is not suppressive and can increase fertility, that is the major concern with TRT, and eventually the suppression is easly reversible). Do you already know it? It could be another idea worth considering before starting real TRT if your are afraid of taking testosterone at such a young age.
And another one would be also to test your DHEA and start thinking about taking a low dose, given its ability to convert to DHT.

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Yep, I understand. I went through your list because I want to know more about everything.
I was always under the impression that supplements = bad and prescription meds = good because supplements aren’t as regulated and that doctors should know more than the general public. From what I’ve been reading the past few days is that a ton of over the counter supplements can actually give you a better quality of life and that prescription meds such as SSRI’s and benzodiazepines can fuck you up pretty bad. Obviously supplements have side effects and need to be managed properly.
I discovered SSRI’s maybe 10 years ago and took them 5-6 years ago for 1-2 years and never heard about all these negative side effects that I’m reading about now. There are PSSD studies that came about after I stopped taking SSRI’s. There are studies from fucking 2017 and even now 2020. How could have I known that I was fucking up my life back in 2014? If I knew I would never ever had touch a pill.
From what I can gather is that big pharma marketing is pretty good and they don’t care about human side effects.
I was also under the impression that supplements = bad due to the gym steroid culture, seems TRT and supplements are a good thing if used with precaution and it’s not as bad as media portraits it to be.

Never heard about it. I will maybe test my DHEA next week and go back to the first doctor that prescribed me 50mg DHEA and 60mg Testosterone and show her my testosterone levels, etc and talk to her about these supplements.
I’m not really afraid of starting TRT, I just want to make sure of what’s wrong with me because as you said TRT may just mask the issues with the brain and that’s not what I want.

I just want to get back to normal where I was masturbating 2 times a day, having random/morning erections and just have a higher desire, sexual motivation and libido. It’s fucking sad living like this.

Do you have any idea on where to get testosterone/hcg/etc in Europe that’s legit? Even this second hormonal doctor I went to told me my 500ng/dl testosterone is healthy and wouldn’t prescribe it to me. I’m not saying I’m going to buy it online/ilegally though, I would very much like to do this with the supervision of a doctor.

I’m starting to think that even at 500ng/dl I will need TRT because I’m still feeling really tired and exhausted all the time.

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Dr Russ Scala has some good info on TRT & neurotransmitters on his YouTube page. He helped answer a few questions I had on Facebook too, but it appears he doesn’t have an account anymore.

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Paxil had me completely impotent for almost a year when I was in 10th grade. I was on Lexapro, Effexor and others I can’t remember the names of at the moment.

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I had a somewhat I think, physical reaction to watermelon. I had some watermelon a week ago or something for two days and I noticed that I had morning erections, they were somewhat weak but I remember having them, I read that if it was due to the watermelon it was because it contains citrulline.

So if I had a reaction to watermelon maybe I should also add some citrulline? Or is this the same as icariin?

I will go back to eating watermelon see if it changes anything and will report back.

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But were you impotent after stopping SSRI’s or were you ok after stopping? Because I’ve stopped years ago and I’m still having issues.

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Not impotent after stopping but it did have a lasting effect that I really didn’t fully recognize until after starting TRT and seeing what legit libido ands having a rock solid fully erect penis was like. Before there were many times that sex felt like a chore. Now it’s a daily necessity.

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Thanks, man. I actually found a naturopath who will prescribe me 200/wk! Even though insurance won’t cover it, with GoodRX, I’ll only be paying about ~$50 for a 200mg/ml x 10ml vial.

Fingers crossed that this helps. I’m going to begin in early September.

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El Nino is talking a lot of science/theory, but as Dexter said, no one knows the cause of PSSD. While supplements help some, they worsen others.

As a PSSD sufferer for 4 years, I can tell you one thing: Do NOT blindly take more drugs and supplements. I’ve only become worse with all the experimentation in that realm.

I’m part of a forum and discord chat for PSSD sufferers, and right now, the most promising treatment seems to be high-dose TRT. It has worked well for others with “normal” levels. I can’t tell you why. Perhaps we had high natural T levels before SSRIs but never tested them so we have no baseline to compare them to. Perhaps our AR gene expression is reduced. It’s anybody’s guess at the end of the day.

What has been shown in the literature is that higher levels of androgens upregulate androgen receptors (ARs) via autoregulation in areas of the brain that are key for sexual function. Here are some studies to read if you are interested:

A. Autoregulation:

  1. Androgen Receptor in Mouse Brain: Sex Differences and Similarities in Autoregulation
    Androgen receptor in mouse brain: sex differences and similarities in autoregulation - PubMed
  2. Distribution and Hormonal Regulation of Androgen Receptor (AR) and AR Messenger Ribonucleic Acid in the Rat Hippocampus
    Distribution and hormonal regulation of androgen receptor (AR) and AR messenger ribonucleic acid in the rat hippocampus - PubMed
  3. Ontogeny and Autoregulation of Androgen Receptor mRNA Expression in the Nervous System
    Ontogeny and autoregulation of androgen receptor mRNA expression in the nervous system - PubMed
  4. Prolonged Androgen Deprivation May Influence the Autoregulation of Estrogen Receptors in the Brain and Pelvic Floor Muscles of Male Rats
    Prolonged androgen deprivation may influence the autoregulation of estrogen receptors in the brain and pelvic floor muscles of male rats - PubMed
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Yes - “chore” is a great word to describe sexual dysfunction after SSRIs. Even when you’re able to perform, the lust, passion, and desire is hardly present.

Dexter, I recall you posting elsewhere about previous opioid use. Do you feel like this permanently worsened your condition or led to your need for TRT? I know opiates/opioids suppress the HPTA quite heavily, but typically hormones rebound upon cessation of the drugs.

After developing PSSD, I fell into a pretty major state of anhedonia. The only things that made me feel normal at this time were alcohol and opioids. I often wonder if I would have recovered naturally had I not played with so many drugs and prescriptions meds after, but instead had given my body a chance to heal. Oh well. I suppose it’s water under the bridge at this point.

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It’s not in the psyche. If you have the symptoms you should give it a go. You are young and you need T to live a normal healthy life. Get after it and don’t over think it. Right now you don’t feel well, And I know the feeling.

It’s a journey. Doesn’t happen over night. Dexter would suggest picking a healthy dose and sticking to it for 3 mo . Don’t make any changes and just stick with it.

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What have you took that worsened you? I was thinking in taking the vitamins the doctors prescribed me then take inositol at first, curcumin and icariin, if those don’t work try St. John’s Wort, and if those don’t work just go the TRT route.

I just want to try everything and give everything a shot, instead of just doing one thing and quitting. TRT might be the answer, it might not be. TRT would be the perfect answer due to fixing the sexual side effects and also making me more aesthetic by exercising.

Can you link me to the forum and discord please?

I will keep your studies in mind, I just need to find a doctor that is willing to prescribe high dose TRT, I’m not sure anyone will do it in my country since it’s such a small country and PSSD isn’t (well) known.

My T went from 300 to 200 and then 500 in the span of 4 years, so I’m assuming the SSRI’s fucked with my hormones and now my body is slowly recovering but maybe I had a higher testosterone level than just the 500.

What’s going to be your stack? Good luck.

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This is what I’m also afraid of. One of the doctors I went that saw my T levels told me that maybe my body is slowly healing after all these years and that some day sexual function will return to normal. But it’s been 3-4 years and nothing has been happening, it’s just gotten worse.

I’m up for TRT for life, it seems to just improve all aspects of ones life.

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I have the prescription for 60mg testosterone cream. Should I still take even though the doctor prescribed it to me because she saw a 2019 blood test that showed my testosterone at 200? It’s now at 500 one year after. I didn’t take anything for it to double, it just did.

However, testosterone increased but sexual side effects are still here, low libido, weak erections, etc.