Hello all,
as per the title, I’m hoping to have advice on how to go about switching from letro to exem.
For context, I’m 4 weeks out of a contest, I’m on 400mg test p, 600mg EQ, 300mg mast p, 300mg tren a, + 30mg var and 30mg win ed. Currently at 91kg flat in the morning , ~7% bf but still holding tons of water. Diet is very low carbs (70g) for 2 days then refeed @300g, cyclically.
I was ok until roughly 3 weeks ago when I suddenly started developing gyno and quickly, despite caber (0.25mg e3d) and nolva (10mg ed). So I freaked out and tossed in letro, stopped the gyno (can still feel a sore lump but much smaller), but I am literally dying from it. Don’t have blood work to see where am at, but energies are non existent, can barely get out of bed and drag my ass to work (which was already difficult from dieting but this is borderline zombie), sex drive and erections are non existent and I was a famelic sex best until I started taking it. No joint pain though.
How would you go about it? I read online of people tapering off the letro (which is what I would do to come off of it completely) but I am not sure it’d be necessary when switching to another AI, also given how quickly exem gets E2 under control.
please please please help a bro out!
GS89
So letro has a half-life of two days, but that doesn’t tell the whole story. Steady state plasma concentrations take between 2-6 weeks to be reached with daily use. Here’s the rub: once that steady state is reached the plasma concentration level is 1.5-2x higher than it is with a single dose. In other words, as you’ve been taking it for about three weeks the concentration in your blood has been slowly building up beyond what you’d get if you had just taken it a few times. In theory you don’t need to taper it because as each dose you’ve taken continues to be excreted and the half-lives of past doses add up, the plasma concentration will winnow down to zero. It would stand to reason that, if your e2 is low (which it sounds like it is, based on symptoms), you’d want to discontinue the letro and wait a few days before starting the aromasin. You want to avoid having both letro and aromasin in you at high concentrations simultaneously, if it can be avoided.
For a handy guide you can do a back-of-the-envelope calculation of the half-life by measuring each one as a unit, i.e. 2 days = 1 half-life, 6 days = 3 half-lives, etc. So if you take 1mg on Monday, by Wednesday the active compound is down to .5mg, by Friday it’s .25mg, and so on. Now again, letro builds up in a somewhat non-linear way, so it’s not exactly as simple as that. But you get the general picture.
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that’s interesting, but it also leaves me confused on why people would even taper letro in the first place to avoid rebound E2, because from your explanation it sounds like it would self taper allowing E2 to slowly build up. Unless E2 stays at 0% untill all letro has cleared the blood stream?
to be on the side of caution, should I taper it by reducing the 2.5mg ED dose to EOD and then to E3D? or would it be better to cut out a 0.5mg does ED until coming off (2.5, 2.0, 1.5, 1, 0.5, 0.25)?
I’m just worried about the rebound with the show approaching and yet I just can’t deal with this extreme fatigue and all the other sides anymore.
Long story short just switch to 10-12mg ED of the aromasin (exem)
I’d also drop that EQ and up the winny to 60mg ED.